| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 14,439,444 | 120,136,000 | 17.85% | ||
| 2 | Redmile Group, LLC | 6,875,274 | 57,202,000 | 8.50% | ||
| 3 | NEA Management Company, LLC | 5,653,029 | 47,033,000 | 6.99% | ||
| 4 | SECTORAL ASSET MANAGEMENT INC | 4,765,498 | 39,649,000 | 5.89% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 3,586,910 | 29,843,000 | 4.43% | ||
| 6 | D. E. Shaw & Co., Inc. | 3,056,164 | 25,427,000 | 3.78% | ||
| 7 | RS INVESTMENT MANAGEMENT CO LLC | 2,850,955 | 23,720,000 | 3.52% | ||
| 8 | Avoro Capital Advisors LLC | 2,824,185 | 23,497,000 | 3.49% | ||
| 9 | VANGUARD GROUP INC | 2,377,689 | 19,783,000 | 2.94% | ||
| 10 | CITADEL ADVISORS LLC | 2,349,515 | 19,548,000 | 2.90% | ||
| 11 | STATE STREET CORP | 2,134,791 | 17,761,000 | 2.64% | ||
| 12 | Palo Alto Investors LP | 1,956,376 | 16,277,000 | 2.42% | ||
| 13 | FRANKLIN RESOURCES INC | 1,954,400 | 16,261,000 | 2.42% | ||
| 14 | ACUTA CAPITAL PARTNERS, LLC | 1,632,720 | 13,584,000 | 2.02% | ||
| 15 | BALYASNY ASSET MANAGEMENT L.P. | 1,484,809 | 12,354,000 | 1.84% | ||
| 16 | MARSHALL WACE, LLP | 1,269,229 | 10,560,000 | 1.57% | ||
| 17 | BlackRock Fund Advisors | 1,261,378 | 10,495,000 | 1.56% | ||
| 18 | GOLDMAN SACHS GROUP INC | 1,124,970 | 9,360,000 | 1.39% | ||
| 19 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,114,327 | 9,271,201 | 1.38% | ||
| 20 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 992,400 | 8,257,000 | 1.23% | ||
| 21 | Informed Momentum Co LLC | 789,840 | 6,571,000 | 0.98% | ||
| 22 | PUTNAM INVESTMENTS LLC | 727,200 | 6,050,000 | 0.90% | ||
| 23 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 699,160 | 5,817,000 | 0.86% | ||
| 24 | Candriam S.C.A. | 695,000 | 5,782,000 | 0.86% | ||
| 25 | BlackRock Institutional Trust Company, N.A. | 572,094 | 4,760,000 | 0.71% | ||
| 26 | FMR LLC | 562,204 | 4,678,000 | 0.69% | ||
| 27 | SPHERA FUNDS MANAGEMENT LTD. | 550,000 | 4,576,000 | 0.68% | ||
| 28 | PICTET ASSET MANAGEMENT LTD | 534,705 | 4,449,000 | 0.66% | ||
| 29 | Connor, Clark & Lunn Investment Management Ltd. | 525,909 | 4,376,000 | 0.65% | ||
| 30 | RENAISSANCE TECHNOLOGIES LLC | 508,700 | 4,232,000 | 0.63% | ||
| 31 | Tourbillon Capital Partners, L.P. | 500,000 | 4,160,000 | 0.62% | ||
| 32 | TFS CAPITAL LLC | 491,191 | 4,087,000 | 0.61% | ||
| 33 | BAKER BROS. ADVISORS LP | 481,697 | 4,008,000 | 0.60% | ||
| 34 | TWO SIGMA INVESTMENTS, LP | 427,502 | 3,557,000 | 0.53% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 417,800 | 3,476,000 | 0.52% | Put | |
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 417,200 | 3,471,000 | 0.52% | Call | |
| 37 | J. Goldman & Co LP | 400,000 | 3,328,000 | 0.49% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 397,448 | 3,306,000 | 0.49% | ||
| 39 | MORGAN STANLEY | 372,667 | 3,101,000 | 0.46% | ||
| 40 | DEUTSCHE BANK AG\ | 372,171 | 3,095,000 | 0.46% | ||
| 41 | Ghost Tree Capital, LLC | 300,000 | 2,496,000 | 0.37% | ||
| 42 | A.R.T. Advisors, LLC | 296,924 | 2,470,000 | 0.37% | ||
| 43 | RUSSELL FRANK CO/ | 290,879 | 2,394,000 | 0.36% | ||
| 44 | OXFORD ASSET MANAGEMENT LLP | 276,885 | 2,284,000 | 0.34% | ||
| 45 | Bank of New York Mellon Corp | 266,773 | 2,220,000 | 0.33% | ||
| 46 | SMITH ASSET MANAGEMENT GROUP LP | 253,060 | 2,105,000 | 0.31% | ||
| 47 | SABBY MANAGEMENT, LLC | 246,697 | 2,053,000 | 0.30% | ||
| 48 | AMERIPRISE FINANCIAL INC | 236,039 | 1,964,000 | 0.29% | ||
| 49 | GROUP ONE TRADING LLC | 235,756 | 1,961,000 | 0.29% | ||
| 50 | MOORE CAPITAL MANAGEMENT, LP | 225,000 | 1,872,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
