| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 10,848,020 | 97,958,000 | 16.53% | ||
| 2 | BAKER BROS. ADVISORS LP | 10,478,204 | 94,618,000 | 15.96% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 7,020,283 | 63,393,000 | 10.70% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 6,926,617 | 62,547,000 | 10.55% | ||
| 5 | STATE STREET CORP | 3,341,212 | 30,171,000 | 5.09% | ||
| 6 | BlackRock Fund Advisors | 2,860,900 | 25,834,000 | 4.36% | ||
| 7 | VANGUARD GROUP INC | 2,461,182 | 22,224,000 | 3.75% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 2,431,123 | 21,953,000 | 3.70% | ||
| 9 | RTW INVESTMENTS, LP | 2,261,361 | 20,420,000 | 3.45% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,913,277 | 17,277,000 | 2.91% | ||
| 11 | VHCP Management, LLC | 1,744,356 | 15,752,000 | 2.66% | ||
| 12 | D. E. Shaw & Co., Inc. | 1,724,137 | 15,569,000 | 2.63% | ||
| 13 | QVT Financial LP | 1,309,382 | 11,824,000 | 1.99% | ||
| 14 | GOLDMAN SACHS GROUP INC | 1,032,568 | 9,325,000 | 1.57% | ||
| 15 | JENNISON ASSOCIATES LLC | 973,099 | 8,787,000 | 1.48% | ||
| 16 | NORTHERN TRUST CORP | 828,938 | 7,486,000 | 1.26% | ||
| 17 | Cormorant Asset Management, LP | 680,000 | 6,140,000 | 1.04% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 389,008 | 3,512,000 | 0.59% | ||
| 19 | Bank of New York Mellon Corp | 365,964 | 3,304,000 | 0.56% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 353,038 | 3,188,000 | 0.54% | ||
| 21 | AXA S.A. | 350,328 | 3,163,000 | 0.53% | ||
| 22 | BLACKROCK ADVISORS LLC | 349,795 | 3,159,000 | 0.53% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 277,300 | 2,504,000 | 0.42% | Call | |
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 242,500 | 2,190,000 | 0.37% | Put | |
| 25 | A.R.T. Advisors, LLC | 242,149 | 2,186,000 | 0.37% | ||
| 26 | Candriam S.C.A. | 240,000 | 2,168,000 | 0.37% | ||
| 27 | AQR CAPITAL MANAGEMENT LLC | 228,635 | 2,064,000 | 0.35% | ||
| 28 | BlackRock Investment Management, LLC | 227,135 | 2,051,000 | 0.35% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 204,106 | 1,844,000 | 0.31% | ||
| 30 | PUTNAM INVESTMENTS LLC | 201,230 | 1,817,000 | 0.31% | ||
| 31 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 160,500 | 1,775,000 | 0.30% | ||
| 32 | DAFNA Capital Management LLC | 166,656 | 1,505,000 | 0.25% | SH | |
| 33 | Connor, Clark & Lunn Investment Management Ltd. | 160,598 | 1,450,000 | 0.24% | ||
| 34 | BlackRock Group LTD | 145,003 | 1,309,000 | 0.22% | ||
| 35 | Vident Investment Advisory, LLC | 131,891 | 1,191,000 | 0.20% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 127,887 | 1,155,000 | 0.19% | ||
| 37 | SIT INVESTMENT ASSOCIATES INC | 120,675 | 1,090,000 | 0.18% | ||
| 38 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 115,496 | 1,043,000 | 0.18% | ||
| 39 | MACQUARIE GROUP LTD | 110,392 | 997,000 | 0.17% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 107,800 | 973,000 | 0.16% | ||
| 41 | TEACHERS ADVISORS, LLC | 100,074 | 904,000 | 0.15% | ||
| 42 | MORGAN STANLEY | 98,765 | 892,000 | 0.15% | ||
| 43 | EMORY UNIVERSITY | 98,161 | 886,000 | 0.15% | ||
| 44 | Nationwide Fund Advisors | 89,460 | 808,000 | 0.14% | ||
| 45 | RHUMBLINE ADVISERS | 77,074 | 696,000 | 0.12% | ||
| 46 | ProShare Advisors LLC | 71,441 | 645,000 | 0.11% | ||
| 47 | CREDIT SUISSE AG/ | 71,455 | 645,000 | 0.11% | ||
| 48 | UBS Group AG | 69,884 | 631,000 | 0.11% | ||
| 49 | Swiss National Bank | 66,300 | 599,000 | 0.10% | ||
| 50 | NATIONAL PLANNING CORP | 64,150 | 594,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
