| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 8,181,816 | 47,864,000 | 30.76% | ||
| 2 | Capital World Investors | 3,426,800 | 20,047,000 | 12.88% | ||
| 3 | BALYASNY ASSET MANAGEMENT L.P. | 2,753,650 | 16,109,000 | 10.35% | ||
| 4 | WASATCH ADVISORS LP | 2,595,950 | 15,186,000 | 9.76% | ||
| 5 | FRANKLIN RESOURCES INC | 1,908,497 | 11,165,000 | 7.17% | ||
| 6 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,400,993 | 8,196,000 | 5.27% | ||
| 7 | BlackRock Fund Advisors | 1,162,397 | 6,800,000 | 4.37% | ||
| 8 | Broadfin Capital, LLC | 1,050,000 | 6,143,000 | 3.95% | ||
| 9 | VANGUARD GROUP INC | 747,836 | 4,375,000 | 2.81% | ||
| 10 | STATE STREET CORP | 351,113 | 2,053,000 | 1.32% | ||
| 11 | Artal Group S.A. | 275,000 | 1,609,000 | 1.03% | ||
| 12 | NORTHERN TRUST CORP | 261,317 | 1,528,000 | 0.98% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 249,516 | 1,460,000 | 0.94% | ||
| 14 | PUTNAM INVESTMENTS LLC | 201,000 | 1,176,000 | 0.76% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 123,204 | 720,000 | 0.46% | ||
| 16 | TIAA CREF INVESTMENT MANAGEMENT LLC | 122,507 | 717,000 | 0.46% | ||
| 17 | JPMORGAN CHASE & CO | 120,708 | 706,000 | 0.45% | ||
| 18 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 120,000 | 702,000 | 0.45% | ||
| 19 | Bank of New York Mellon Corp | 111,163 | 650,000 | 0.42% | ||
| 20 | MARSHALL WACE, LLP | 98,298 | 575,000 | 0.37% | ||
| 21 | BlackRock Investment Management, LLC | 87,702 | 513,000 | 0.33% | ||
| 22 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 74,843 | 438,000 | 0.28% | ||
| 23 | BANQUE PICTET & CIE SA | 71,960 | 421,000 | 0.27% | ||
| 24 | ROYCE & ASSOCIATES LP | 70,000 | 410,000 | 0.26% | ||
| 25 | DEUTSCHE BANK AG\ | 64,878 | 377,000 | 0.24% | ||
| 26 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 62,800 | 367,000 | 0.24% | ||
| 27 | KEYBANK NATIONAL ASSOCIATION/OH | 55,504 | 325,000 | 0.21% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,900 | 321,000 | 0.21% | Call | |
| 29 | RENAISSANCE TECHNOLOGIES LLC | 54,900 | 321,000 | 0.21% | ||
| 30 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 54,254 | 317,000 | 0.20% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 51,339 | 301,000 | 0.19% | ||
| 32 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 50,000 | 293,000 | 0.19% | ||
| 33 | BAKER BROS. ADVISORS LP | 50,000 | 293,000 | 0.19% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 49,962 | 292,000 | 0.19% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 41,251 | 241,000 | 0.15% | ||
| 36 | ProShare Advisors LLC | 39,427 | 231,000 | 0.15% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 36,446 | 213,000 | 0.14% | ||
| 38 | TEACHERS ADVISORS, LLC | 33,989 | 199,000 | 0.13% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 33,500 | 196,000 | 0.13% | Put | |
| 40 | RHUMBLINE ADVISERS | 32,663 | 191,000 | 0.12% | ||
| 41 | DekaBank Deutsche Girozentrale | 25,000 | 146,000 | 0.09% | ||
| 42 | TFS CAPITAL LLC | 24,817 | 145,000 | 0.09% | ||
| 43 | MORGAN STANLEY | 20,452 | 120,000 | 0.08% | ||
| 44 | Nationwide Fund Advisors | 20,554 | 120,000 | 0.08% | ||
| 45 | CREDIT SUISSE AG/ | 20,469 | 119,000 | 0.08% | ||
| 46 | BARCLAYS PLC | 21,462 | 108,000 | 0.07% | ||
| 47 | AMERICAN INTERNATIONAL GROUP, INC. | 17,893 | 104,674 | 0.07% | ||
| 48 | Gruss Capital Management LP | 15,931 | 93,000 | 0.06% | ||
| 49 | D. E. Shaw & Co., Inc. | 14,501 | 85,000 | 0.05% | ||
| 50 | PNC FINANCIAL SERVICES GROUP, INC. | 14,240 | 84,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
