| 1 |
BVF INC/IL |
8,596,772 |
38,685,000 |
31.40% |
|
|
| 2 |
Capital World Investors |
3,426,800 |
15,421,000 |
12.52% |
|
|
| 3 |
BALYASNY ASSET MANAGEMENT L.P. |
2,764,227 |
12,439,000 |
10.10% |
|
|
| 4 |
WASATCH ADVISORS LP |
2,543,034 |
11,444,000 |
9.29% |
|
|
| 5 |
FRANKLIN RESOURCES INC |
1,824,797 |
8,212,000 |
6.66% |
|
|
| 6 |
WESTFIELD CAPITAL MANAGEMENT CO LP |
1,366,793 |
6,151,000 |
4.99% |
|
|
| 7 |
BlackRock Fund Advisors |
1,188,581 |
5,349,000 |
4.34% |
|
|
| 8 |
Broadfin Capital, LLC |
800,000 |
3,600,000 |
2.92% |
|
|
| 9 |
VANGUARD GROUP INC |
776,025 |
3,492,000 |
2.83% |
|
|
| 10 |
GREAT POINT PARTNERS LLC |
483,741 |
2,177,000 |
1.77% |
|
|
| 11 |
Gruss Capital Management LP |
429,592 |
1,933,000 |
1.57% |
|
|
| 12 |
STATE STREET CORP |
350,785 |
1,579,000 |
1.28% |
|
|
| 13 |
Artal Group S.A. |
275,000 |
1,238,000 |
1.00% |
|
|
| 14 |
NORTHERN TRUST CORP |
272,163 |
1,225,000 |
0.99% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
244,545 |
1,100,000 |
0.89% |
|
|
| 16 |
PUTNAM INVESTMENTS LLC |
201,000 |
904,000 |
0.73% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
126,785 |
570,000 |
0.46% |
|
|
| 18 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
120,000 |
540,000 |
0.44% |
|
|
| 19 |
JPMORGAN CHASE & CO |
119,069 |
536,000 |
0.44% |
|
|
| 20 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
117,349 |
528,000 |
0.43% |
|
|
| 21 |
Bank of New York Mellon Corp |
111,163 |
500,000 |
0.41% |
|
|
| 22 |
Artal Group S.A. |
100,000 |
450,000 |
0.37% |
Call |
|
| 23 |
BlackRock Investment Management, LLC |
90,935 |
409,000 |
0.33% |
|
|
| 24 |
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
74,843 |
337,000 |
0.27% |
|
|
| 25 |
BANQUE PICTET & CIE SA |
71,960 |
324,000 |
0.26% |
|
|
| 26 |
ROYCE & ASSOCIATES LP |
70,000 |
315,000 |
0.26% |
|
|
| 27 |
RENAISSANCE TECHNOLOGIES LLC |
68,300 |
307,000 |
0.25% |
|
|
| 28 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
62,800 |
283,000 |
0.23% |
|
|
| 29 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
50,249 |
226,000 |
0.18% |
|
|
| 30 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
50,000 |
225,000 |
0.18% |
|
|
| 31 |
BAKER BROS. ADVISORS LP |
50,000 |
225,000 |
0.18% |
|
|
| 32 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
44,919 |
202,000 |
0.16% |
|
|
| 33 |
KEYBANK NATIONAL ASSOCIATION/OH |
38,405 |
173,000 |
0.14% |
|
|
| 34 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
36,408 |
164,000 |
0.13% |
|
|
| 35 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
35,000 |
158,000 |
0.13% |
|
|
| 36 |
TEACHERS ADVISORS, LLC |
33,989 |
153,000 |
0.12% |
|
|
| 37 |
ProShare Advisors LLC |
33,067 |
149,000 |
0.12% |
|
|
| 38 |
RHUMBLINE ADVISERS |
32,663 |
147,000 |
0.12% |
|
|
| 39 |
D. E. Shaw & Co., Inc. |
26,799 |
121,000 |
0.10% |
|
|
| 40 |
MILLENNIUM MANAGEMENT LLC |
26,403 |
119,000 |
0.10% |
|
|
| 41 |
DekaBank Deutsche Girozentrale |
25,500 |
115,000 |
0.09% |
|
|
| 42 |
CREDIT SUISSE AG/ |
21,295 |
96,000 |
0.08% |
|
|
| 43 |
BARCLAYS PLC |
23,536 |
94,000 |
0.08% |
|
|
| 44 |
Nationwide Fund Advisors |
20,945 |
94,000 |
0.08% |
|
|
| 45 |
SG Americas Securities, LLC |
20,102 |
90,000 |
0.07% |
|
|
| 46 |
DEUTSCHE BANK AG\ |
20,023 |
89,000 |
0.07% |
|
|
| 47 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
18,884 |
85,000 |
0.07% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
17,881 |
80,465 |
0.07% |
|
|
| 49 |
PNC FINANCIAL SERVICES GROUP, INC. |
14,240 |
64,000 |
0.05% |
|
|
| 50 |
GROUP ONE TRADING LLC |
12,446 |
56,000 |
0.05% |
|
|
