| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 8,182,052 | 20,373,000 | 32.95% | ||
| 2 | WASATCH ADVISORS LP | 2,449,783 | 5,732,000 | 9.27% | ||
| 3 | FRANKLIN RESOURCES INC | 2,165,397 | 5,392,000 | 8.72% | ||
| 4 | Capital World Investors | 1,489,848 | 3,710,000 | 6.00% | ||
| 5 | BlackRock Fund Advisors | 1,279,222 | 3,185,000 | 5.15% | ||
| 6 | VANGUARD GROUP INC | 1,018,062 | 2,535,000 | 4.10% | ||
| 7 | BALYASNY ASSET MANAGEMENT L.P. | 955,134 | 2,378,000 | 3.85% | ||
| 8 | Artal Group S.A. | 900,000 | 2,241,000 | 3.62% | ||
| 9 | VIVO CAPITAL, LLC | 887,906 | 2,211,000 | 3.58% | ||
| 10 | CREDIT SUISSE AG/ | 765,996 | 1,907,000 | 3.08% | ||
| 11 | Gruss Capital Management LP | 482,000 | 1,200,000 | 1.94% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 441,069 | 1,098,000 | 1.78% | ||
| 13 | STATE STREET CORP | 414,741 | 1,031,000 | 1.67% | ||
| 14 | NORTHERN TRUST CORP | 298,208 | 743,000 | 1.20% | ||
| 15 | D. E. Shaw & Co., Inc. | 237,779 | 592,000 | 0.96% | ||
| 16 | Abingworth LLP | 215,000 | 533,000 | 0.86% | ||
| 17 | PUTNAM INVESTMENTS LLC | 201,000 | 500,000 | 0.81% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 169,054 | 421,000 | 0.68% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 153,186 | 381,000 | 0.62% | ||
| 20 | JACOBS LEVY EQUITY MANAGEMENT, INC | 145,313 | 362,000 | 0.59% | ||
| 21 | Spark Investment Management LLC | 123,900 | 308,000 | 0.50% | ||
| 22 | BLACKROCK ADVISORS LLC | 117,348 | 292,000 | 0.47% | ||
| 23 | BlackRock Investment Management, LLC | 99,912 | 249,000 | 0.40% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 99,603 | 248,000 | 0.40% | ||
| 25 | BANK OF AMERICA CORP /DE/ | 98,989 | 246,000 | 0.40% | ||
| 26 | Bank of New York Mellon Corp | 94,951 | 236,000 | 0.38% | ||
| 27 | DEUTSCHE BANK AG\ | 92,015 | 228,000 | 0.37% | ||
| 28 | JPMORGAN CHASE & CO | 86,218 | 215,000 | 0.35% | ||
| 29 | CITADEL ADVISORS LLC | 70,753 | 176,000 | 0.28% | ||
| 30 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 69,613 | 173,000 | 0.28% | ||
| 31 | GOLDMAN SACHS GROUP INC | 66,714 | 166,000 | 0.27% | ||
| 32 | TWO SIGMA INVESTMENTS, LP | 63,617 | 158,000 | 0.26% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 62,800 | 156,000 | 0.25% | ||
| 34 | Parallax Volatility Advisers, L.P. | 62,400 | 155,000 | 0.25% | Put | |
| 35 | Parallax Volatility Advisers, L.P. | 60,557 | 151,000 | 0.24% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 59,746 | 149,000 | 0.24% | ||
| 37 | TFS CAPITAL LLC | 56,709 | 141,000 | 0.23% | ||
| 38 | KEYBANK NATIONAL ASSOCIATION/OH | 56,288 | 140,000 | 0.23% | ||
| 39 | BANQUE PICTET & CIE SA | 54,178 | 135,000 | 0.22% | ||
| 40 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | 125,000 | 0.20% | ||
| 41 | BAKER BROS. ADVISORS LP | 49,064 | 122,000 | 0.20% | ||
| 42 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 45,518 | 113,000 | 0.18% | ||
| 43 | TEACHERS ADVISORS, LLC | 40,872 | 102,000 | 0.16% | ||
| 44 | ProShare Advisors LLC | 35,848 | 89,000 | 0.14% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 35,000 | 88,000 | 0.14% | ||
| 46 | ROYCE & ASSOCIATES LP | 32,900 | 82,000 | 0.13% | ||
| 47 | CITIGROUP INC | 28,642 | 72,000 | 0.12% | ||
| 48 | RHUMBLINE ADVISERS | 28,635 | 71,000 | 0.11% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 25,500 | 63,000 | 0.10% | ||
| 50 | RUSSELL FRANK CO/ | 24,300 | 61,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
