| 1 |
BVF INC/IL |
8,182,052 |
36,737,000 |
35.91% |
|
|
| 2 |
WASATCH ADVISORS LP |
2,573,898 |
11,557,000 |
11.30% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
2,165,397 |
9,723,000 |
9.51% |
|
|
| 4 |
BlackRock Fund Advisors |
1,160,147 |
5,209,000 |
5.09% |
|
|
| 5 |
VANGUARD GROUP INC |
1,083,075 |
4,863,000 |
4.75% |
|
|
| 6 |
Artal Group S.A. |
900,000 |
4,041,000 |
3.95% |
|
|
| 7 |
Sio Capital Management, LLC |
642,828 |
2,886,000 |
2.82% |
|
|
| 8 |
OXFORD ASSET MANAGEMENT LLP |
536,521 |
2,409,000 |
2.36% |
|
|
| 9 |
BANK OF AMERICA CORP /DE/ |
441,095 |
1,981,000 |
1.94% |
|
|
| 10 |
Nantahala Capital Management, LLC |
428,687 |
1,925,000 |
1.88% |
|
|
| 11 |
STATE STREET CORP |
407,178 |
1,828,000 |
1.79% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
344,234 |
1,546,000 |
1.51% |
|
|
| 13 |
Boston Partners |
255,815 |
1,149,000 |
1.12% |
|
|
| 14 |
NORTHERN TRUST CORP |
227,673 |
1,022,000 |
1.00% |
|
|
| 15 |
BLACKROCK ADVISORS LLC |
205,673 |
923,000 |
0.90% |
|
|
| 16 |
DEUTSCHE BANK AG\ |
204,444 |
916,000 |
0.90% |
|
|
| 17 |
PUTNAM INVESTMENTS LLC |
201,000 |
902,000 |
0.88% |
|
|
| 18 |
D. E. Shaw & Co., Inc. |
193,989 |
871,000 |
0.85% |
|
|
| 19 |
Connective Capital Management, LLC |
191,881 |
861,000 |
0.84% |
|
|
| 20 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
150,321 |
675,000 |
0.66% |
|
|
| 21 |
P.A.W. CAPITAL CORP |
150,000 |
674,000 |
0.66% |
|
|
| 22 |
Iguana Healthcare Management, LLC |
150,000 |
674,000 |
0.66% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
147,922 |
664,000 |
0.65% |
|
|
| 24 |
LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
136,911 |
615,000 |
0.60% |
|
|
| 25 |
Bank of New York Mellon Corp |
117,265 |
526,000 |
0.51% |
|
|
| 26 |
Nationwide Fund Advisors |
96,077 |
431,000 |
0.42% |
|
|
| 27 |
BlackRock Investment Management, LLC |
90,704 |
407,000 |
0.40% |
|
|
| 28 |
BANQUE PICTET & CIE SA |
75,206 |
338,000 |
0.33% |
|
|
| 29 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
75,299 |
338,000 |
0.33% |
|
|
| 30 |
KEYBANK NATIONAL ASSOCIATION/OH |
70,766 |
318,000 |
0.31% |
|
|
| 31 |
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
69,613 |
313,000 |
0.31% |
|
|
| 32 |
RENAISSANCE TECHNOLOGIES LLC |
69,681 |
313,000 |
0.31% |
|
|
| 33 |
CITADEL ADVISORS LLC |
67,085 |
301,000 |
0.29% |
|
|
| 34 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
67,071 |
301,000 |
0.29% |
|
|
| 35 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
62,800 |
282,000 |
0.28% |
|
|
| 36 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
58,496 |
263,000 |
0.26% |
|
|
| 37 |
GOLDMAN SACHS GROUP INC |
56,389 |
253,000 |
0.25% |
|
|
| 38 |
MORGAN STANLEY |
55,184 |
248,000 |
0.24% |
|
|
| 39 |
BAKER BROS. ADVISORS LP |
49,064 |
220,000 |
0.22% |
|
|
| 40 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
44,740 |
201,000 |
0.20% |
|
|
| 41 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
39,966 |
180,000 |
0.18% |
|
|
| 42 |
ProShare Advisors LLC |
38,159 |
171,000 |
0.17% |
|
|
| 43 |
TEACHERS ADVISORS, LLC |
37,174 |
167,000 |
0.16% |
|
|
| 44 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
34,422 |
155,000 |
0.15% |
|
|
| 45 |
EMERALD ACQUISITION LTD. |
34,500 |
155,000 |
0.15% |
|
|
| 46 |
CREDIT SUISSE AG/ |
32,981 |
148,000 |
0.14% |
|
|
| 47 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
32,000 |
144,000 |
0.14% |
|
|
| 48 |
BANK OF MONTREAL /CAN/ |
32,059 |
144,000 |
0.14% |
|
|
| 49 |
ALLIANCEBERNSTEIN L.P. |
31,700 |
142,000 |
0.14% |
|
|
| 50 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
31,052 |
139,000 |
0.14% |
|
|
