| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 6,677,722 | 54,090,000 | 26.55% | ||
| 2 | Capital World Investors | 3,467,240 | 28,085,000 | 13.79% | ||
| 3 | WASATCH ADVISORS LP | 2,432,302 | 19,702,000 | 9.67% | ||
| 4 | FRANKLIN RESOURCES INC | 1,768,497 | 14,325,000 | 7.03% | ||
| 5 | BALYASNY ASSET MANAGEMENT L.P. | 1,631,326 | 13,214,000 | 6.49% | ||
| 6 | BlackRock Fund Advisors | 1,253,840 | 10,156,000 | 4.99% | ||
| 7 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,102,332 | 8,929,000 | 4.38% | ||
| 8 | VANGUARD GROUP INC | 955,053 | 7,736,000 | 3.80% | ||
| 9 | Artal Group S.A. | 900,000 | 7,290,000 | 3.58% | ||
| 10 | CREDIT SUISSE AG/ | 494,612 | 4,007,000 | 1.97% | ||
| 11 | Gruss Capital Management LP | 482,000 | 3,904,000 | 1.92% | ||
| 12 | EverPoint Asset Management, LLC | 475,000 | 3,848,000 | 1.89% | ||
| 13 | STATE STREET CORP | 412,727 | 3,341,000 | 1.64% | ||
| 14 | NORTHERN TRUST CORP | 299,443 | 2,426,000 | 1.19% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 283,362 | 2,295,000 | 1.13% | ||
| 16 | Abingworth LLP | 215,000 | 1,739,000 | 0.85% | ||
| 17 | PUTNAM INVESTMENTS LLC | 201,000 | 1,628,000 | 0.80% | ||
| 18 | D. E. Shaw & Co., Inc. | 186,886 | 1,514,000 | 0.74% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 154,465 | 1,250,000 | 0.61% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 99,603 | 807,000 | 0.40% | ||
| 21 | BlackRock Investment Management, LLC | 98,094 | 795,000 | 0.39% | ||
| 22 | BLACKROCK ADVISORS LLC | 89,693 | 727,000 | 0.36% | ||
| 23 | JPMORGAN CHASE & CO | 82,267 | 666,000 | 0.33% | ||
| 24 | Bank of New York Mellon Corp | 80,056 | 648,000 | 0.32% | ||
| 25 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 74,843 | 606,000 | 0.30% | ||
| 26 | Redmile Group, LLC | 63,189 | 512,000 | 0.25% | ||
| 27 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 62,800 | 509,000 | 0.25% | ||
| 28 | Parallax Volatility Advisers, L.P. | 62,400 | 505,000 | 0.25% | Put | |
| 29 | Parallax Volatility Advisers, L.P. | 60,557 | 491,000 | 0.24% | ||
| 30 | DEUTSCHE BANK AG\ | 57,902 | 467,000 | 0.23% | ||
| 31 | BANQUE PICTET & CIE SA | 54,178 | 439,000 | 0.22% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,873 | 420,000 | 0.21% | ||
| 33 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | 405,000 | 0.20% | ||
| 34 | BAKER BROS. ADVISORS LP | 49,064 | 397,000 | 0.19% | ||
| 35 | RENAISSANCE TECHNOLOGIES LLC | 44,300 | 359,000 | 0.18% | ||
| 36 | TEACHERS ADVISORS, LLC | 40,872 | 331,000 | 0.16% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 39,852 | 323,000 | 0.16% | ||
| 38 | ProShare Advisors LLC | 39,562 | 320,000 | 0.16% | ||
| 39 | CITADEL ADVISORS LLC | 39,101 | 316,000 | 0.16% | ||
| 40 | KEYBANK NATIONAL ASSOCIATION/OH | 38,405 | 311,000 | 0.15% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 35,000 | 284,000 | 0.14% | ||
| 42 | ROYCE & ASSOCIATES LP | 33,300 | 270,000 | 0.13% | ||
| 43 | TWO SIGMA INVESTMENTS, LP | 32,537 | 264,000 | 0.13% | ||
| 44 | RHUMBLINE ADVISERS | 28,635 | 232,000 | 0.11% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,100 | 228,000 | 0.11% | Call | |
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 25,500 | 207,000 | 0.10% | ||
| 47 | METROPOLITAN LIFE INSURANCE CO/NY | 22,688 | 184,000 | 0.09% | ||
| 48 | DekaBank Deutsche Girozentrale | 22,500 | 182,000 | 0.09% | ||
| 49 | PICTET BANK & TRUST Ltd | 21,028 | 170,000 | 0.08% | ||
| 50 | Creative Planning | 20,170 | 163,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
