| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 7,270,013 | 59,832,000 | 27.52% | ||
| 2 | Capital World Investors | 3,467,240 | 28,535,000 | 13.12% | ||
| 3 | WASATCH ADVISORS LP | 2,510,161 | 20,659,000 | 9.50% | ||
| 4 | BALYASNY ASSET MANAGEMENT L.P. | 2,245,275 | 18,479,000 | 8.50% | ||
| 5 | FRANKLIN RESOURCES INC | 1,666,397 | 13,714,000 | 6.31% | ||
| 6 | BlackRock Fund Advisors | 1,303,124 | 10,725,000 | 4.93% | ||
| 7 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,124,397 | 9,254,000 | 4.26% | ||
| 8 | Artal Group S.A. | 900,000 | 7,407,000 | 3.41% | ||
| 9 | VANGUARD GROUP INC | 865,193 | 7,121,000 | 3.27% | ||
| 10 | Gruss Capital Management LP | 482,000 | 3,967,000 | 1.82% | ||
| 11 | Redmile Group, LLC | 476,293 | 3,920,000 | 1.80% | ||
| 12 | EverPoint Asset Management, LLC | 430,000 | 3,539,000 | 1.63% | ||
| 13 | STATE STREET CORP | 419,261 | 3,449,000 | 1.59% | ||
| 14 | MARSHALL WACE, LLP | 282,713 | 2,327,000 | 1.07% | ||
| 15 | NORTHERN TRUST CORP | 261,145 | 2,149,000 | 0.99% | ||
| 16 | Abingworth LLP | 215,000 | 1,769,000 | 0.81% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 207,478 | 1,708,000 | 0.79% | ||
| 18 | PUTNAM INVESTMENTS LLC | 201,000 | 1,654,000 | 0.76% | ||
| 19 | D. E. Shaw & Co., Inc. | 169,195 | 1,392,000 | 0.64% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 143,272 | 1,179,000 | 0.54% | ||
| 21 | RENAISSANCE TECHNOLOGIES LLC | 127,377 | 1,048,000 | 0.48% | ||
| 22 | Bank of New York Mellon Corp | 114,418 | 942,000 | 0.43% | ||
| 23 | BlackRock Investment Management, LLC | 100,271 | 825,000 | 0.38% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 99,603 | 820,000 | 0.38% | ||
| 25 | JPMORGAN CHASE & CO | 91,222 | 751,000 | 0.35% | ||
| 26 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 74,843 | 616,000 | 0.28% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 72,146 | 594,000 | 0.27% | ||
| 28 | BANQUE PICTET & CIE SA | 71,960 | 592,000 | 0.27% | ||
| 29 | ROYCE & ASSOCIATES LP | 70,000 | 576,000 | 0.26% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 68,700 | 565,000 | 0.26% | Put | |
| 31 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 62,800 | 517,000 | 0.24% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,089 | 420,000 | 0.19% | ||
| 33 | CREDIT SUISSE AG/ | 50,177 | 413,000 | 0.19% | ||
| 34 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | 412,000 | 0.19% | ||
| 35 | BAKER BROS. ADVISORS LP | 49,064 | 404,000 | 0.19% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,000 | 387,000 | 0.18% | Call | |
| 37 | MORGAN STANLEY | 41,806 | 344,000 | 0.16% | ||
| 38 | DEUTSCHE BANK AG\ | 41,741 | 342,000 | 0.16% | ||
| 39 | TEACHERS ADVISORS, LLC | 40,872 | 336,000 | 0.15% | ||
| 40 | EAGLE GLOBAL ADVISORS LLC | 39,882 | 328,000 | 0.15% | ||
| 41 | ProShare Advisors LLC | 38,444 | 316,000 | 0.15% | ||
| 42 | KEYBANK NATIONAL ASSOCIATION/OH | 38,405 | 316,000 | 0.15% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 35,000 | 289,000 | 0.13% | ||
| 44 | NEW YORK STATE COMMON RETIREMENT FUND | 30,840 | 254,000 | 0.12% | ||
| 45 | RHUMBLINE ADVISERS | 25,598 | 211,000 | 0.10% | ||
| 46 | Spot Trading L.L.C | 25,000 | 206,000 | 0.09% | Call | |
| 47 | DekaBank Deutsche Girozentrale | 21,000 | 173,000 | 0.08% | ||
| 48 | METROPOLITAN LIFE INSURANCE CO/NY | 18,968 | 156,000 | 0.07% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,789 | 155,000 | 0.07% | ||
| 50 | Nationwide Fund Advisors | 18,691 | 154,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
