| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 8,303,084 | 62,688,000 | 31.20% | ||
| 2 | Capital World Investors | 3,467,240 | 26,178,000 | 13.03% | ||
| 3 | WASATCH ADVISORS LP | 2,536,535 | 19,151,000 | 9.53% | ||
| 4 | BALYASNY ASSET MANAGEMENT L.P. | 1,867,597 | 14,100,000 | 7.02% | ||
| 5 | FRANKLIN RESOURCES INC | 1,666,397 | 12,581,000 | 6.26% | ||
| 6 | BlackRock Fund Advisors | 1,286,518 | 9,713,000 | 4.83% | ||
| 7 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,272,098 | 9,604,000 | 4.78% | ||
| 8 | VANGUARD GROUP INC | 848,751 | 6,408,000 | 3.19% | ||
| 9 | Artal Group S.A. | 800,000 | 6,040,000 | 3.01% | ||
| 10 | Gruss Capital Management LP | 532,000 | 4,017,000 | 2.00% | ||
| 11 | STATE STREET CORP | 376,966 | 2,843,000 | 1.42% | ||
| 12 | Avoro Capital Advisors LLC | 323,607 | 2,443,000 | 1.22% | ||
| 13 | FIRST MANHATTAN CO. LLC. | 260,500 | 1,966,000 | 0.98% | ||
| 14 | NORTHERN TRUST CORP | 256,378 | 1,935,000 | 0.96% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 245,378 | 1,853,000 | 0.92% | ||
| 16 | MARSHALL WACE, LLP | 227,658 | 1,719,000 | 0.86% | ||
| 17 | PUTNAM INVESTMENTS LLC | 201,000 | 1,518,000 | 0.76% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 139,744 | 1,055,000 | 0.53% | ||
| 19 | BLUE ARROW CAPITAL MANAGEMENT LLC | 124,600 | 941,000 | 0.47% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 123,653 | 934,000 | 0.46% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 120,203 | 908,000 | 0.45% | ||
| 22 | D. E. Shaw & Co., Inc. | 111,770 | 844,000 | 0.42% | ||
| 23 | Bank of New York Mellon Corp | 109,999 | 830,000 | 0.41% | ||
| 24 | Abingworth LLP | 109,700 | 824,000 | 0.41% | ||
| 25 | JPMORGAN CHASE & CO | 98,372 | 743,000 | 0.37% | ||
| 26 | BlackRock Investment Management, LLC | 90,807 | 686,000 | 0.34% | ||
| 27 | RENAISSANCE TECHNOLOGIES LLC | 81,700 | 617,000 | 0.31% | ||
| 28 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 74,843 | 565,000 | 0.28% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 62,800 | 555,000 | 0.28% | ||
| 30 | BANQUE PICTET & CIE SA | 71,960 | 543,000 | 0.27% | ||
| 31 | ROYCE & ASSOCIATES LP | 70,000 | 529,000 | 0.26% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 50,465 | 381,000 | 0.19% | ||
| 33 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | 378,000 | 0.19% | ||
| 34 | BAKER BROS. ADVISORS LP | 49,064 | 370,000 | 0.18% | ||
| 35 | TEACHERS ADVISORS, LLC | 40,517 | 306,000 | 0.15% | ||
| 36 | ProShare Advisors LLC | 40,202 | 304,000 | 0.15% | ||
| 37 | KEYBANK NATIONAL ASSOCIATION/OH | 38,405 | 290,000 | 0.14% | ||
| 38 | RHUMBLINE ADVISERS | 37,713 | 285,000 | 0.14% | ||
| 39 | Spark Investment Management LLC | 35,700 | 268,000 | 0.13% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 35,000 | 265,000 | 0.13% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,300 | 259,000 | 0.13% | Call | |
| 42 | CREDIT SUISSE AG/ | 26,985 | 203,000 | 0.10% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,300 | 199,000 | 0.10% | Put | |
| 44 | MORGAN STANLEY | 25,892 | 196,000 | 0.10% | ||
| 45 | EAGLE GLOBAL ADVISORS LLC | 23,940 | 181,000 | 0.09% | ||
| 46 | METROPOLITAN LIFE INSURANCE CO/NY | 23,422 | 177,000 | 0.09% | ||
| 47 | DekaBank Deutsche Girozentrale | 20,500 | 155,000 | 0.08% | ||
| 48 | Nationwide Fund Advisors | 20,083 | 152,000 | 0.08% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,449 | 146,000 | 0.07% | ||
| 50 | Redmile Group, LLC | 17,500 | 132,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
