| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 7,798,572 | 57,709,000 | 33.28% | ||
| 2 | WASATCH ADVISORS LP | 2,427,932 | 17,967,000 | 10.36% | ||
| 3 | FRANKLIN RESOURCES INC | 2,131,997 | 15,777,000 | 9.10% | ||
| 4 | BlackRock Fund Advisors | 1,410,479 | 10,438,000 | 6.02% | ||
| 5 | VANGUARD GROUP INC | 1,151,255 | 8,519,000 | 4.91% | ||
| 6 | Artal Group S.A. | 546,278 | 4,042,000 | 2.33% | ||
| 7 | RENAISSANCE TECHNOLOGIES LLC | 470,581 | 3,482,000 | 2.01% | ||
| 8 | Nantahala Capital Management, LLC | 467,455 | 3,459,000 | 1.99% | ||
| 9 | ACADIAN ASSET MANAGEMENT LLC | 450,809 | 3,334,000 | 1.92% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 429,612 | 3,179,000 | 1.83% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 409,640 | 3,031,000 | 1.75% | ||
| 12 | STATE STREET CORP | 402,792 | 2,981,000 | 1.72% | ||
| 13 | D. E. Shaw & Co., Inc. | 343,425 | 2,541,000 | 1.47% | ||
| 14 | Sio Capital Management, LLC | 325,250 | 2,407,000 | 1.39% | ||
| 15 | OXFORD ASSET MANAGEMENT LLP | 280,147 | 2,073,000 | 1.20% | ||
| 16 | Iguana Healthcare Management, LLC | 270,000 | 1,998,000 | 1.15% | ||
| 17 | NORTHERN TRUST CORP | 246,931 | 1,828,000 | 1.05% | ||
| 18 | Invesco Ltd. | 244,782 | 1,811,000 | 1.04% | ||
| 19 | PUTNAM INVESTMENTS LLC | 235,484 | 1,743,000 | 1.01% | ||
| 20 | DEUTSCHE BANK AG\ | 190,404 | 1,408,000 | 0.81% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 188,011 | 1,391,000 | 0.80% | ||
| 22 | BANK OF AMERICA CORP /DE/ | 158,387 | 1,172,000 | 0.68% | ||
| 23 | CITY FINANCIAL INVESTMENT CO LTD | 146,789 | 1,086,000 | 0.63% | ||
| 24 | BLACKROCK ADVISORS LLC | 138,294 | 1,023,000 | 0.59% | ||
| 25 | P.A.W. CAPITAL CORP | 120,000 | 888,000 | 0.51% | ||
| 26 | MORGAN STANLEY | 110,861 | 820,000 | 0.47% | ||
| 27 | Bank of New York Mellon Corp | 108,998 | 806,000 | 0.46% | ||
| 28 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 104,999 | 776,000 | 0.45% | ||
| 29 | JACOBS LEVY EQUITY MANAGEMENT, INC | 95,921 | 710,000 | 0.41% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 93,497 | 692,000 | 0.40% | ||
| 31 | FEDERATED HERMES, INC. | 92,096 | 682,000 | 0.39% | ||
| 32 | BlackRock Investment Management, LLC | 92,004 | 681,000 | 0.39% | ||
| 33 | ADAMS DIVERSIFIED EQUITY FUND, INC. | 85,500 | 633,000 | 0.37% | ||
| 34 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 77,396 | 573,000 | 0.33% | ||
| 35 | BANQUE PICTET & CIE SA | 75,206 | 557,000 | 0.32% | ||
| 36 | Piermont Capital Management Inc. | 66,498 | 492,000 | 0.28% | ||
| 37 | RUSSELL INVESTMENTS GROUP, LTD. | 62,168 | 483,000 | 0.28% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 62,800 | 465,000 | 0.27% | ||
| 39 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 69,613 | 456,000 | 0.26% | ||
| 40 | Virtu KCG Holdings LLC | 59,051 | 437,000 | 0.25% | ||
| 41 | GOLDMAN SACHS GROUP INC | 58,344 | 432,000 | 0.25% | ||
| 42 | KEYBANK NATIONAL ASSOCIATION/OH | 54,982 | 407,000 | 0.23% | ||
| 43 | TFS CAPITAL LLC | 51,561 | 382,000 | 0.22% | ||
| 44 | BAKER BROS. ADVISORS LP | 49,064 | 363,000 | 0.21% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 47,340 | 350,000 | 0.20% | ||
| 46 | PANAGORA ASSET MANAGEMENT INC | 47,254 | 350,000 | 0.20% | ||
| 47 | ALPS ADVISORS INC | 45,942 | 340,000 | 0.20% | ||
| 48 | MILLENNIUM MANAGEMENT LLC | 45,358 | 336,000 | 0.19% | ||
| 49 | Connor, Clark & Lunn Investment Management Ltd. | 44,475 | 329,000 | 0.19% | ||
| 50 | STRS OHIO | 44,200 | 327,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
