| 1 |
BVF INC/IL |
8,064,019 |
48,707,000 |
35.54% |
|
|
| 2 |
WASATCH ADVISORS LP |
2,525,647 |
15,255,000 |
11.13% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
2,165,397 |
13,079,000 |
9.54% |
|
|
| 4 |
BlackRock Fund Advisors |
1,267,682 |
7,657,000 |
5.59% |
|
|
| 5 |
Artal Group S.A. |
1,200,000 |
7,248,000 |
5.29% |
|
|
| 6 |
VANGUARD GROUP INC |
1,118,772 |
6,757,000 |
4.93% |
|
|
| 7 |
Sio Capital Management, LLC |
613,890 |
3,708,000 |
2.71% |
|
|
| 8 |
Nantahala Capital Management, LLC |
466,440 |
2,817,000 |
2.06% |
|
|
| 9 |
STATE STREET CORP |
418,119 |
2,526,000 |
1.84% |
|
|
| 10 |
BlackRock Institutional Trust Company, N.A. |
375,965 |
2,271,000 |
1.66% |
|
|
| 11 |
OXFORD ASSET MANAGEMENT LLP |
327,389 |
1,977,000 |
1.44% |
|
|
| 12 |
BANK OF AMERICA CORP /DE/ |
321,207 |
1,940,000 |
1.42% |
|
|
| 13 |
DEUTSCHE BANK AG\ |
263,299 |
1,589,000 |
1.16% |
|
|
| 14 |
Boston Partners |
255,815 |
1,545,000 |
1.13% |
|
|
| 15 |
NORTHERN TRUST CORP |
235,505 |
1,422,000 |
1.04% |
|
|
| 16 |
BLACKROCK ADVISORS LLC |
202,491 |
1,223,000 |
0.89% |
|
|
| 17 |
PUTNAM INVESTMENTS LLC |
201,000 |
1,214,000 |
0.89% |
|
|
| 18 |
RENAISSANCE TECHNOLOGIES LLC |
197,981 |
1,196,000 |
0.87% |
|
|
| 19 |
D. E. Shaw & Co., Inc. |
182,287 |
1,101,000 |
0.80% |
|
|
| 20 |
ACADIAN ASSET MANAGEMENT LLC |
172,299 |
1,040,000 |
0.76% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
152,943 |
923,000 |
0.67% |
|
|
| 22 |
Iguana Healthcare Management, LLC |
150,000 |
906,000 |
0.66% |
|
|
| 23 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
132,721 |
802,000 |
0.59% |
|
|
| 24 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
127,396 |
769,000 |
0.56% |
|
|
| 25 |
Spark Investment Management LLC |
121,600 |
734,000 |
0.54% |
|
|
| 26 |
Bank of New York Mellon Corp |
104,898 |
633,000 |
0.46% |
|
|
| 27 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
97,975 |
591,000 |
0.43% |
|
|
| 28 |
BlackRock Investment Management, LLC |
90,739 |
548,000 |
0.40% |
|
|
| 29 |
P.A.W. CAPITAL CORP |
90,000 |
544,000 |
0.40% |
|
|
| 30 |
BANQUE PICTET & CIE SA |
75,206 |
454,000 |
0.33% |
|
|
| 31 |
KEYBANK NATIONAL ASSOCIATION/OH |
70,766 |
427,000 |
0.31% |
|
|
| 32 |
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
69,613 |
420,000 |
0.31% |
|
|
| 33 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
64,065 |
387,000 |
0.28% |
|
|
| 34 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
62,800 |
379,000 |
0.28% |
|
|
| 35 |
Geduld E E |
50,000 |
302,000 |
0.22% |
|
|
| 36 |
BAKER BROS. ADVISORS LP |
49,064 |
296,000 |
0.22% |
|
|
| 37 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
48,440 |
293,000 |
0.21% |
|
|
| 38 |
Invesco Ltd. |
48,131 |
291,000 |
0.21% |
|
|
| 39 |
TEACHERS ADVISORS, LLC |
37,174 |
225,000 |
0.16% |
|
|
| 40 |
GOLDMAN SACHS GROUP INC |
35,534 |
215,000 |
0.16% |
|
|
| 41 |
ProShare Advisors LLC |
32,397 |
196,000 |
0.14% |
|
|
| 42 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
32,000 |
194,000 |
0.14% |
|
|
| 43 |
ALLIANCEBERNSTEIN L.P. |
31,700 |
191,000 |
0.14% |
|
|
| 44 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
31,040 |
187,000 |
0.14% |
|
|
| 45 |
Connor, Clark & Lunn Investment Management Ltd. |
27,700 |
167,000 |
0.12% |
|
|
| 46 |
RHUMBLINE ADVISERS |
26,722 |
161,000 |
0.12% |
|
|
| 47 |
CREDIT SUISSE AG/ |
21,360 |
129,000 |
0.09% |
|
|
| 48 |
Virtu KCG Holdings LLC |
20,857 |
126,000 |
0.09% |
|
|
| 49 |
LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
19,600 |
118,000 |
0.09% |
|
|
| 50 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
17,700 |
107,000 |
0.08% |
Call |
|
