| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 7,796,516 | 51,691,000 | 29.42% | ||
| 2 | Capital World Investors | 3,426,800 | 22,720,000 | 12.93% | ||
| 3 | WASATCH ADVISORS LP | 2,607,001 | 17,284,000 | 9.84% | ||
| 4 | BALYASNY ASSET MANAGEMENT L.P. | 2,290,421 | 15,185,000 | 8.64% | ||
| 5 | FRANKLIN RESOURCES INC | 1,908,497 | 12,653,000 | 7.20% | ||
| 6 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,402,303 | 9,297,000 | 5.29% | ||
| 7 | BlackRock Fund Advisors | 1,214,011 | 8,049,000 | 4.58% | ||
| 8 | Broadfin Capital, LLC | 1,050,000 | 6,962,000 | 3.96% | ||
| 9 | VANGUARD GROUP INC | 736,434 | 4,883,000 | 2.78% | ||
| 10 | STATE STREET CORP | 353,767 | 2,349,000 | 1.34% | ||
| 11 | NORTHERN TRUST CORP | 298,475 | 1,979,000 | 1.13% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 284,760 | 1,888,000 | 1.07% | ||
| 13 | Artal Group S.A. | 275,000 | 1,823,000 | 1.04% | ||
| 14 | GREAT POINT PARTNERS LLC | 249,700 | 1,656,000 | 0.94% | ||
| 15 | PUTNAM INVESTMENTS LLC | 201,000 | 1,333,000 | 0.76% | ||
| 16 | RENAISSANCE TECHNOLOGIES LLC | 199,780 | 1,325,000 | 0.75% | ||
| 17 | Visium Asset Management, LP | 151,200 | 1,003,000 | 0.57% | ||
| 18 | DEUTSCHE BANK AG\ | 147,158 | 975,000 | 0.55% | ||
| 19 | JPMORGAN CHASE & CO | 130,968 | 868,000 | 0.49% | ||
| 20 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 120,000 | 796,000 | 0.45% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 119,873 | 794,000 | 0.45% | ||
| 22 | Bank of New York Mellon Corp | 111,354 | 739,000 | 0.42% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 97,776 | 648,000 | 0.37% | ||
| 24 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 80,500 | 534,000 | 0.30% | ||
| 25 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 74,843 | 496,000 | 0.28% | ||
| 26 | BANQUE PICTET & CIE SA | 71,960 | 477,000 | 0.27% | ||
| 27 | ROYCE & ASSOCIATES LP | 70,000 | 464,000 | 0.26% | ||
| 28 | BlackRock Investment Management, LLC | 68,899 | 457,000 | 0.26% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 61,111 | 405,000 | 0.23% | ||
| 30 | ProShare Advisors LLC | 57,709 | 383,000 | 0.22% | ||
| 31 | KEYBANK NATIONAL ASSOCIATION/OH | 56,613 | 375,000 | 0.21% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 59,000 | 371,000 | 0.21% | ||
| 33 | JANE STREET GROUP, LLC | 53,968 | 358,000 | 0.20% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 51,675 | 343,000 | 0.20% | ||
| 35 | BAKER BROS. ADVISORS LP | 50,000 | 332,000 | 0.19% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,162 | 293,000 | 0.17% | ||
| 37 | CREDIT SUISSE AG/ | 43,433 | 289,000 | 0.16% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 41,894 | 278,000 | 0.16% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 38,755 | 257,000 | 0.15% | ||
| 40 | Aperio Group, LLC | 35,619 | 236,000 | 0.13% | ||
| 41 | TEACHERS ADVISORS, LLC | 33,989 | 225,000 | 0.13% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 27,500 | 182,000 | 0.10% | Call | |
| 43 | DekaBank Deutsche Girozentrale | 26,500 | 176,000 | 0.10% | ||
| 44 | BARCLAYS PLC | 27,885 | 168,000 | 0.10% | ||
| 45 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 21,654 | 144,000 | 0.08% | ||
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,699 | 138,000 | 0.08% | ||
| 47 | RHUMBLINE ADVISERS | 20,625 | 137,000 | 0.08% | ||
| 48 | MORGAN STANLEY | 19,371 | 128,000 | 0.07% | ||
| 49 | Swiss National Bank | 18,900 | 125,000 | 0.07% | ||
| 50 | Nationwide Fund Advisors | 18,889 | 125,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
