| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 8,596,772 | 58,716,000 | 30.79% | ||
| 2 | Capital World Investors | 3,467,240 | 28,501,000 | 14.94% | ||
| 3 | WASATCH ADVISORS LP | 2,536,928 | 17,327,000 | 9.09% | ||
| 4 | BALYASNY ASSET MANAGEMENT L.P. | 1,810,456 | 12,365,000 | 6.48% | ||
| 5 | FRANKLIN RESOURCES INC | 1,724,109 | 11,776,000 | 6.17% | ||
| 6 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,276,833 | 8,721,000 | 4.57% | ||
| 7 | BlackRock Fund Advisors | 1,267,706 | 8,658,000 | 4.54% | ||
| 8 | VANGUARD GROUP INC | 827,630 | 5,653,000 | 2.96% | ||
| 9 | Gruss Capital Management LP | 483,000 | 3,299,000 | 1.73% | ||
| 10 | Artal Group S.A. | 400,000 | 2,732,000 | 1.43% | Call | |
| 11 | Artal Group S.A. | 400,000 | 2,732,000 | 1.43% | ||
| 12 | FMR LLC | 399,200 | 2,727,000 | 1.43% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 395,000 | 2,698,000 | 1.41% | ||
| 14 | STATE STREET CORP | 375,622 | 2,565,000 | 1.34% | ||
| 15 | FIRST MANHATTAN CO. LLC. | 260,500 | 1,779,000 | 0.93% | ||
| 16 | NORTHERN TRUST CORP | 253,755 | 1,733,000 | 0.91% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 234,504 | 1,602,000 | 0.84% | ||
| 18 | PUTNAM INVESTMENTS LLC | 201,000 | 1,373,000 | 0.72% | ||
| 19 | GOLDMAN SACHS GROUP INC | 146,834 | 1,003,000 | 0.53% | ||
| 20 | BLUE ARROW CAPITAL MANAGEMENT LLC | 140,000 | 956,000 | 0.50% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 129,041 | 881,000 | 0.46% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 124,120 | 848,000 | 0.44% | ||
| 23 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 120,000 | 820,000 | 0.43% | ||
| 24 | Bank of New York Mellon Corp | 109,999 | 751,000 | 0.39% | ||
| 25 | BARCLAYS PLC | 119,410 | 717,000 | 0.38% | ||
| 26 | JPMORGAN CHASE & CO | 102,847 | 703,000 | 0.37% | ||
| 27 | D. E. Shaw & Co., Inc. | 101,158 | 691,000 | 0.36% | ||
| 28 | BlackRock Investment Management, LLC | 91,444 | 625,000 | 0.33% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 62,800 | 555,000 | 0.29% | ||
| 30 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 74,843 | 511,000 | 0.27% | ||
| 31 | BANQUE PICTET & CIE SA | 71,960 | 491,000 | 0.26% | ||
| 32 | ROYCE & ASSOCIATES LP | 70,000 | 478,000 | 0.25% | ||
| 33 | RENAISSANCE TECHNOLOGIES LLC | 63,923 | 437,000 | 0.23% | ||
| 34 | DEUTSCHE BANK AG\ | 53,183 | 362,000 | 0.19% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 50,465 | 345,000 | 0.18% | ||
| 36 | BAKER BROS. ADVISORS LP | 50,000 | 342,000 | 0.18% | ||
| 37 | CREDIT SUISSE AG/ | 48,111 | 328,000 | 0.17% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 42,659 | 291,000 | 0.15% | ||
| 39 | KEYBANK NATIONAL ASSOCIATION/OH | 38,405 | 262,000 | 0.14% | ||
| 40 | RHUMBLINE ADVISERS | 35,913 | 245,000 | 0.13% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 35,000 | 240,000 | 0.13% | ||
| 42 | ProShare Advisors LLC | 34,462 | 235,000 | 0.12% | ||
| 43 | TEACHERS ADVISORS, LLC | 33,989 | 232,000 | 0.12% | ||
| 44 | TWO SIGMA INVESTMENTS, LP | 32,220 | 220,000 | 0.12% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,000 | 205,000 | 0.11% | Put | |
| 46 | Virtu KCG Holdings LLC | 27,387 | 187,000 | 0.10% | ||
| 47 | RUSSELL FRANK CO/ | 24,405 | 166,000 | 0.09% | ||
| 48 | DekaBank Deutsche Girozentrale | 23,000 | 152,000 | 0.08% | ||
| 49 | Nationwide Fund Advisors | 20,945 | 143,000 | 0.07% | ||
| 50 | JACOBS LEVY EQUITY MANAGEMENT, INC | 19,732 | 135,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
