| 1 |
FMR LLC |
3,206,401 |
11,286,000 |
16.04% |
|
|
| 2 |
LANSDOWNE PARTNERS (UK) LLP |
2,321,865 |
8,173,000 |
11.61% |
|
|
| 3 |
BVF INC/IL |
1,527,000 |
5,375,000 |
7.64% |
|
|
| 4 |
BlackRock Institutional Trust Company, N.A. |
1,433,064 |
5,044,000 |
7.17% |
|
|
| 5 |
VANGUARD GROUP INC |
1,259,276 |
4,433,000 |
6.30% |
|
|
| 6 |
D. E. Shaw & Co., Inc. |
941,711 |
3,314,000 |
4.71% |
|
|
| 7 |
BlackRock Fund Advisors |
816,242 |
2,873,000 |
4.08% |
|
|
| 8 |
WASATCH ADVISORS LP |
655,081 |
2,306,000 |
3.28% |
|
|
| 9 |
IRONWOOD INVESTMENT MANAGEMENT LLC |
596,583 |
2,100,000 |
2.98% |
|
|
| 10 |
STATE STREET CORP |
503,490 |
1,777,000 |
2.53% |
|
|
| 11 |
RENAISSANCE TECHNOLOGIES LLC |
498,161 |
1,754,000 |
2.49% |
|
|
| 12 |
TEACHERS ADVISORS, LLC |
444,949 |
1,566,000 |
2.23% |
|
|
| 13 |
DEUTSCHE BANK AG\ |
405,271 |
1,425,000 |
2.03% |
|
|
| 14 |
SPHERA FUNDS MANAGEMENT LTD. |
363,212 |
1,279,000 |
1.82% |
|
|
| 15 |
NORTHERN TRUST CORP |
347,548 |
1,224,000 |
1.74% |
|
|
| 16 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
319,647 |
1,125,000 |
1.60% |
|
|
| 17 |
WELLINGTON MANAGEMENT GROUP LLP |
303,419 |
1,068,000 |
1.52% |
|
|
| 18 |
MORGAN STANLEY |
262,150 |
923,000 |
1.31% |
|
|
| 19 |
BLACKROCK ADVISORS LLC |
249,439 |
878,000 |
1.25% |
|
|
| 20 |
MILLENNIUM MANAGEMENT LLC |
200,000 |
704,000 |
1.00% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
182,659 |
643,000 |
0.91% |
|
|
| 22 |
A.R.T. Advisors, LLC |
179,772 |
632,000 |
0.90% |
|
|
| 23 |
Bank of New York Mellon Corp |
168,089 |
592,000 |
0.84% |
|
|
| 24 |
First Light Asset Management, LLC |
165,046 |
581,000 |
0.83% |
|
|
| 25 |
GEODE CAPITAL MANAGEMENT, LLC |
161,411 |
568,000 |
0.81% |
|
|
| 26 |
Numeric Investors LLC |
157,952 |
556,000 |
0.79% |
|
|
| 27 |
GROUP ONE TRADING LLC |
144,210 |
508,000 |
0.72% |
|
|
| 28 |
Palo Alto Investors LP |
123,686 |
435,000 |
0.62% |
|
|
| 29 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
122,232 |
431,000 |
0.61% |
|
|
| 30 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
120,075 |
423,000 |
0.60% |
|
|
| 31 |
BlackRock Investment Management, LLC |
117,069 |
412,000 |
0.59% |
|
|
| 32 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
111,446 |
392,000 |
0.56% |
|
|
| 33 |
DIMENSIONAL FUND ADVISORS LP |
105,256 |
371,000 |
0.53% |
|
|
| 34 |
CITADEL ADVISORS LLC |
86,098 |
303,000 |
0.43% |
|
|
| 35 |
GOLDMAN SACHS GROUP INC |
77,470 |
273,000 |
0.39% |
|
|
| 36 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
75,761 |
267,000 |
0.38% |
|
|
| 37 |
PANAGORA ASSET MANAGEMENT INC |
75,577 |
266,000 |
0.38% |
|
|
| 38 |
KEYBANK NATIONAL ASSOCIATION/OH |
71,395 |
251,000 |
0.36% |
|
|
| 39 |
Allianz Asset Management GmbH |
69,309 |
244,000 |
0.35% |
|
|
| 40 |
CREDIT SUISSE AG/ |
66,166 |
233,000 |
0.33% |
|
|
| 41 |
Alyeska Investment Group, L.P. |
65,789 |
232,000 |
0.33% |
Call |
|
| 42 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
64,700 |
228,000 |
0.32% |
Put |
|
| 43 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
63,525 |
224,000 |
0.32% |
|
|
| 44 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
51,900 |
183,000 |
0.26% |
Call |
|
| 45 |
Nine Chapters Capital Management LLC |
51,600 |
182,000 |
0.26% |
|
|
| 46 |
TFS CAPITAL LLC |
48,801 |
172,000 |
0.24% |
|
|
| 47 |
STONERIDGE INVESTMENT PARTNERS LLC |
48,141 |
169,000 |
0.24% |
|
|
| 48 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
45,900 |
162,000 |
0.23% |
|
|
| 49 |
AMERICAN CENTURY COMPANIES INC |
42,052 |
148,000 |
0.21% |
|
|
| 50 |
CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. |
41,550 |
146,000 |
0.21% |
|
|
