| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 4,340,729 | 30,602,000 | 16.16% | ||
| 2 | LANSDOWNE PARTNERS (UK) LLP | 2,321,865 | 16,369,000 | 8.64% | ||
| 3 | FMR LLC | 2,119,797 | 14,945,000 | 7.89% | ||
| 4 | EcoR1 Capital, LLC | 2,052,800 | 14,472,000 | 7.64% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 1,928,693 | 13,597,000 | 7.18% | ||
| 6 | VANGUARD GROUP INC | 1,469,958 | 10,363,000 | 5.47% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 1,322,214 | 9,322,000 | 4.92% | ||
| 8 | ACADIAN ASSET MANAGEMENT LLC | 1,223,446 | 8,624,000 | 4.55% | ||
| 9 | BlackRock Fund Advisors | 887,957 | 6,260,000 | 3.31% | ||
| 10 | CITIGROUP INC | 745,400 | 5,255,000 | 2.77% | ||
| 11 | STATE STREET CORP | 545,460 | 3,845,000 | 2.03% | ||
| 12 | WASATCH ADVISORS LP | 479,242 | 3,225,000 | 1.70% | ||
| 13 | NORTHERN TRUST CORP | 417,189 | 2,942,000 | 1.55% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 341,944 | 2,411,000 | 1.27% | ||
| 15 | RUSSELL FRANK CO/ | 338,825 | 2,389,000 | 1.26% | ||
| 16 | D. E. Shaw & Co., Inc. | 306,426 | 2,160,000 | 1.14% | ||
| 17 | Informed Momentum Co LLC | 306,003 | 2,157,000 | 1.14% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 278,830 | 1,965,000 | 1.04% | ||
| 19 | Matarin Capital Management, LLC | 271,530 | 1,914,287 | 1.01% | ||
| 20 | Bank of New York Mellon Corp | 249,536 | 1,760,000 | 0.93% | ||
| 21 | Invesco Ltd. | 238,325 | 1,680,000 | 0.89% | ||
| 22 | PANAGORA ASSET MANAGEMENT INC | 217,016 | 1,530,000 | 0.81% | ||
| 23 | PRUDENTIAL FINANCIAL INC | 196,662 | 1,386,000 | 0.73% | ||
| 24 | RENAISSANCE TECHNOLOGIES LLC | 184,479 | 1,301,000 | 0.69% | ||
| 25 | AMERIPRISE FINANCIAL INC | 182,791 | 1,289,000 | 0.68% | ||
| 26 | BALYASNY ASSET MANAGEMENT L.P. | 176,559 | 1,245,000 | 0.66% | ||
| 27 | Iguana Healthcare Management, LLC | 175,000 | 1,234,000 | 0.65% | ||
| 28 | IRONWOOD INVESTMENT MANAGEMENT LLC | 174,305 | 1,229,000 | 0.65% | ||
| 29 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 164,060 | 1,157,000 | 0.61% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 148,100 | 1,044,000 | 0.55% | Call | |
| 31 | BlackRock Investment Management, LLC | 127,988 | 902,000 | 0.48% | ||
| 32 | Palo Alto Investors LP | 123,686 | 872,000 | 0.46% | ||
| 33 | BLACKROCK ADVISORS LLC | 123,630 | 872,000 | 0.46% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 123,007 | 867,000 | 0.46% | ||
| 35 | TFS CAPITAL LLC | 122,027 | 860,000 | 0.45% | ||
| 36 | Trexquant Investment LP | 112,403 | 792,000 | 0.42% | ||
| 37 | DEUTSCHE BANK AG\ | 109,844 | 772,000 | 0.41% | ||
| 38 | MILLENNIUM MANAGEMENT LLC | 101,891 | 718,000 | 0.38% | ||
| 39 | TWO SIGMA INVESTMENTS, LP | 100,824 | 711,000 | 0.38% | ||
| 40 | Spark Investment Management LLC | 100,500 | 708,000 | 0.37% | ||
| 41 | Healthcare Value Capital, LLC | 100,000 | 705,000 | 0.37% | ||
| 42 | Asset Management One Co., Ltd. | 88,124 | 621,000 | 0.33% | ||
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 82,675 | 583,000 | 0.31% | ||
| 44 | ClariVest Asset Management LLC | 77,263 | 544,000 | 0.29% | ||
| 45 | A.R.T. Advisors, LLC | 75,197 | 530,000 | 0.28% | ||
| 46 | ANALYTIC INVESTORS, LLC | 74,206 | 523,000 | 0.28% | ||
| 47 | JACOBS LEVY EQUITY MANAGEMENT, INC | 74,087 | 522,000 | 0.28% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 73,475 | 518,000 | 0.27% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 73,000 | 515,000 | 0.27% | Put | |
| 50 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 69,121 | 487,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
