| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,733,186 | 21,892,000 | 13.92% | ||
| 2 | BVF INC/IL | 2,443,100 | 19,569,000 | 12.44% | ||
| 3 | LANSDOWNE PARTNERS (UK) LLP | 2,321,865 | 18,598,000 | 11.83% | ||
| 4 | BlackRock Institutional Trust Company, N.A. | 1,465,951 | 11,742,000 | 7.47% | ||
| 5 | VANGUARD GROUP INC | 1,244,385 | 9,967,000 | 6.34% | ||
| 6 | BlackRock Fund Advisors | 944,173 | 7,563,000 | 4.81% | ||
| 7 | D. E. Shaw & Co., Inc. | 933,327 | 7,476,000 | 4.75% | ||
| 8 | WASATCH ADVISORS LP | 621,164 | 4,976,000 | 3.16% | ||
| 9 | IRONWOOD INVESTMENT MANAGEMENT LLC | 597,319 | 4,785,000 | 3.04% | ||
| 10 | STATE STREET CORP | 509,167 | 4,079,000 | 2.59% | ||
| 11 | SPHERA FUNDS MANAGEMENT LTD. | 493,212 | 3,951,000 | 2.51% | ||
| 12 | TEACHERS ADVISORS, LLC | 480,155 | 3,846,000 | 2.45% | ||
| 13 | NORTHERN TRUST CORP | 329,711 | 2,641,000 | 1.68% | ||
| 14 | WELLINGTON MANAGEMENT GROUP LLP | 274,039 | 2,195,000 | 1.40% | ||
| 15 | BLACKROCK ADVISORS LLC | 245,868 | 1,969,000 | 1.25% | ||
| 16 | JACOBS LEVY EQUITY MANAGEMENT, INC | 222,781 | 1,784,000 | 1.13% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 182,626 | 1,463,000 | 0.93% | ||
| 18 | First Light Asset Management, LLC | 179,189 | 1,435,000 | 0.91% | ||
| 19 | Numeric Investors LLC | 175,152 | 1,403,000 | 0.89% | ||
| 20 | DEUTSCHE BANK AG\ | 173,821 | 1,392,000 | 0.89% | ||
| 21 | Bank of New York Mellon Corp | 161,681 | 1,295,000 | 0.82% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 161,642 | 1,294,000 | 0.82% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 158,389 | 1,269,000 | 0.81% | ||
| 24 | PANAGORA ASSET MANAGEMENT INC | 152,838 | 1,224,000 | 0.78% | ||
| 25 | Palo Alto Investors LP | 123,686 | 991,000 | 0.63% | ||
| 26 | RUSSELL FRANK CO/ | 119,433 | 956,000 | 0.61% | ||
| 27 | CITADEL ADVISORS LLC | 118,464 | 949,000 | 0.60% | ||
| 28 | BlackRock Investment Management, LLC | 115,217 | 923,000 | 0.59% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 111,975 | 864,000 | 0.55% | ||
| 30 | MORGAN STANLEY | 104,014 | 833,000 | 0.53% | ||
| 31 | DIMENSIONAL FUND ADVISORS LP | 102,802 | 823,000 | 0.52% | ||
| 32 | Healthcare Value Capital, LLC | 100,000 | 801,000 | 0.51% | ||
| 33 | GOLDMAN SACHS GROUP INC | 100,000 | 801,000 | 0.51% | Put | |
| 34 | GOLDMAN SACHS GROUP INC | 100,000 | 801,000 | 0.51% | Call | |
| 35 | OXFORD ASSET MANAGEMENT LLP | 98,080 | 722,000 | 0.46% | ||
| 36 | GOLDMAN SACHS GROUP INC | 78,652 | 630,000 | 0.40% | ||
| 37 | ALGERT GLOBAL LLC | 77,850 | 624,000 | 0.40% | ||
| 38 | TFS CAPITAL LLC | 68,510 | 549,000 | 0.35% | ||
| 39 | Alyeska Investment Group, L.P. | 65,789 | 527,000 | 0.34% | Call | |
| 40 | KEYBANK NATIONAL ASSOCIATION/OH | 65,061 | 521,000 | 0.33% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 63,798 | 511,000 | 0.32% | ||
| 42 | STONERIDGE INVESTMENT PARTNERS LLC | 61,386 | 492,000 | 0.31% | ||
| 43 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 60,850 | 487,000 | 0.31% | ||
| 44 | Nine Chapters Capital Management LLC | 60,000 | 481,000 | 0.31% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,100 | 369,000 | 0.23% | Put | |
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,900 | 368,000 | 0.23% | ||
| 47 | RHUMBLINE ADVISERS | 45,330 | 363,000 | 0.23% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 41,400 | 332,000 | 0.21% | Call | |
| 49 | CREDIT SUISSE AG/ | 34,185 | 274,000 | 0.17% | ||
| 50 | Quotient Investors, LLC | 30,000 | 240,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
