| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,083,356 | 14,738,000 | 14.12% | ||
| 2 | LANSDOWNE PARTNERS (UK) LLP | 2,321,865 | 11,099,000 | 10.63% | ||
| 3 | Alpha Wave Global, LP | 1,785,000 | 8,532,000 | 8.17% | ||
| 4 | BlackRock Institutional Trust Company, N.A. | 1,341,188 | 6,411,000 | 6.14% | ||
| 5 | BVF INC/IL | 1,317,000 | 6,295,000 | 6.03% | ||
| 6 | VANGUARD GROUP INC | 1,211,321 | 5,790,000 | 5.55% | ||
| 7 | BlackRock Fund Advisors | 843,197 | 4,030,000 | 3.86% | ||
| 8 | D. E. Shaw & Co., Inc. | 837,349 | 4,003,000 | 3.83% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 728,472 | 3,482,000 | 3.34% | ||
| 10 | IRONWOOD INVESTMENT MANAGEMENT LLC | 558,536 | 2,670,000 | 2.56% | ||
| 11 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 553,008 | 2,643,000 | 2.53% | ||
| 12 | STATE STREET CORP | 493,368 | 2,360,000 | 2.26% | ||
| 13 | TEACHERS ADVISORS, LLC | 444,949 | 2,127,000 | 2.04% | ||
| 14 | MORGAN STANLEY | 438,779 | 2,098,000 | 2.01% | ||
| 15 | TIAA CREF INVESTMENT MANAGEMENT LLC | 362,870 | 1,735,000 | 1.66% | ||
| 16 | NORTHERN TRUST CORP | 345,035 | 1,649,000 | 1.58% | ||
| 17 | I.G. INVESTMENT MANAGEMENT, LTD. | 284,895 | 1,362,000 | 1.30% | ||
| 18 | GROUP ONE TRADING LLC | 277,531 | 1,327,000 | 1.27% | ||
| 19 | DEUTSCHE BANK AG\ | 273,814 | 1,307,000 | 1.25% | ||
| 20 | Allianz Asset Management GmbH | 267,460 | 1,278,000 | 1.22% | ||
| 21 | RENAISSANCE TECHNOLOGIES LLC | 257,537 | 1,231,000 | 1.18% | ||
| 22 | BLACKROCK ADVISORS LLC | 247,866 | 1,185,000 | 1.14% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 216,200 | 1,033,000 | 0.99% | Put | |
| 24 | DRIEHAUS CAPITAL MANAGEMENT LLC | 205,019 | 980,000 | 0.94% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 201,552 | 964,000 | 0.92% | ||
| 26 | WASATCH ADVISORS LP | 173,176 | 828,000 | 0.79% | ||
| 27 | Bank of New York Mellon Corp | 168,259 | 804,000 | 0.77% | ||
| 28 | First Light Asset Management, LLC | 161,571 | 772,000 | 0.74% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 158,323 | 756,000 | 0.72% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 138,800 | 663,000 | 0.64% | Call | |
| 31 | ROYAL BANK OF CANADA | 130,000 | 621,000 | 0.59% | Call | |
| 32 | Palo Alto Investors LP | 123,686 | 591,000 | 0.57% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 120,075 | 574,000 | 0.55% | ||
| 34 | BlackRock Investment Management, LLC | 113,429 | 542,000 | 0.52% | ||
| 35 | A.R.T. Advisors, LLC | 108,850 | 520,000 | 0.50% | ||
| 36 | DIMENSIONAL FUND ADVISORS LP | 105,256 | 503,000 | 0.48% | ||
| 37 | Spot Trading L.L.C | 105,000 | 502,000 | 0.48% | Put | |
| 38 | BANK OF MONTREAL /CAN/ | 104,000 | 497,000 | 0.48% | Call | |
| 39 | CREDIT SUISSE AG/ | 98,545 | 471,000 | 0.45% | ||
| 40 | Alyeska Investment Group, L.P. | 65,789 | 314,000 | 0.30% | Call | |
| 41 | SPHERA FUNDS MANAGEMENT LTD. | 65,100 | 311,000 | 0.30% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 63,162 | 302,000 | 0.29% | ||
| 43 | Spot Trading L.L.C | 53,711 | 257,000 | 0.25% | ||
| 44 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 53,633 | 256,000 | 0.25% | ||
| 45 | STONERIDGE INVESTMENT PARTNERS LLC | 48,141 | 230,000 | 0.22% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,900 | 220,000 | 0.21% | ||
| 47 | Healthcare Value Capital, LLC | 41,666 | 199,000 | 0.19% | ||
| 48 | RHUMBLINE ADVISERS | 41,230 | 197,000 | 0.19% | ||
| 49 | KEYBANK NATIONAL ASSOCIATION/OH | 40,549 | 194,000 | 0.19% | ||
| 50 | TUDOR INVESTMENT CORP ET AL | 38,969 | 186,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
