| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | LANSDOWNE PARTNERS (UK) LLP | 2,321,865 | 15,533,000 | 10.61% | ||
| 2 | BVF INC/IL | 2,106,989 | 14,096,000 | 9.63% | ||
| 3 | FMR LLC | 1,902,482 | 12,728,000 | 8.70% | ||
| 4 | BlackRock Institutional Trust Company, N.A. | 1,482,335 | 9,917,000 | 6.78% | ||
| 5 | VANGUARD GROUP INC | 1,241,857 | 8,308,000 | 5.68% | ||
| 6 | BlackRock Fund Advisors | 888,300 | 5,943,000 | 4.06% | ||
| 7 | MORGAN STANLEY | 849,478 | 5,683,000 | 3.88% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 801,197 | 5,360,000 | 3.66% | ||
| 9 | CITIGROUP INC | 629,257 | 4,210,000 | 2.88% | ||
| 10 | TEACHERS ADVISORS, LLC | 563,685 | 3,771,000 | 2.58% | ||
| 11 | STATE STREET CORP | 551,038 | 3,689,000 | 2.52% | ||
| 12 | WASATCH ADVISORS LP | 547,779 | 3,665,000 | 2.50% | ||
| 13 | D. E. Shaw & Co., Inc. | 475,592 | 3,181,000 | 2.17% | ||
| 14 | OXFORD ASSET MANAGEMENT LLP | 402,108 | 2,690,000 | 1.84% | ||
| 15 | Invesco Ltd. | 376,223 | 2,517,000 | 1.72% | ||
| 16 | SPHERA FUNDS MANAGEMENT LTD. | 372,250 | 2,490,000 | 1.70% | ||
| 17 | TFS CAPITAL LLC | 366,042 | 2,449,000 | 1.67% | ||
| 18 | NORTHERN TRUST CORP | 350,152 | 2,342,000 | 1.60% | ||
| 19 | KENNEDY CAPITAL MANAGEMENT LLC | 348,701 | 2,333,000 | 1.59% | ||
| 20 | IRONWOOD INVESTMENT MANAGEMENT LLC | 341,116 | 2,282,000 | 1.56% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 284,313 | 1,902,000 | 1.30% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 244,799 | 1,638,000 | 1.12% | ||
| 23 | PANAGORA ASSET MANAGEMENT INC | 219,799 | 1,470,000 | 1.00% | ||
| 24 | RENAISSANCE TECHNOLOGIES LLC | 219,700 | 1,470,000 | 1.00% | ||
| 25 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 216,368 | 1,447,000 | 0.99% | ||
| 26 | PDT Partners, LLC | 195,800 | 1,310,000 | 0.90% | ||
| 27 | BLACKROCK ADVISORS LLC | 185,783 | 1,243,000 | 0.85% | ||
| 28 | SMITH ASSET MANAGEMENT GROUP LP | 177,010 | 1,184,000 | 0.81% | ||
| 29 | Numeric Investors LLC | 160,900 | 1,076,000 | 0.74% | ||
| 30 | Matarin Capital Management, LLC | 160,767 | 1,075,531 | 0.73% | ||
| 31 | PRUDENTIAL FINANCIAL INC | 151,200 | 1,012,000 | 0.69% | ||
| 32 | Bank of New York Mellon Corp | 134,113 | 1,002,000 | 0.68% | ||
| 33 | BlackRock Investment Management, LLC | 125,895 | 842,000 | 0.58% | ||
| 34 | Palo Alto Investors LP | 123,686 | 827,000 | 0.57% | ||
| 35 | DIMENSIONAL FUND ADVISORS LP | 114,853 | 768,000 | 0.52% | ||
| 36 | JACOBS LEVY EQUITY MANAGEMENT, INC | 112,987 | 756,000 | 0.52% | ||
| 37 | MILLENNIUM MANAGEMENT LLC | 110,000 | 736,000 | 0.50% | Call | |
| 38 | Healthcare Value Capital, LLC | 100,000 | 669,000 | 0.46% | ||
| 39 | STRS OHIO | 92,500 | 618,000 | 0.42% | ||
| 40 | ACADIAN ASSET MANAGEMENT LLC | 90,538 | 606,000 | 0.41% | ||
| 41 | Nine Chapters Capital Management LLC | 89,100 | 596,000 | 0.41% | ||
| 42 | STONERIDGE INVESTMENT PARTNERS LLC | 87,926 | 588,000 | 0.40% | ||
| 43 | DEUTSCHE BANK AG\ | 84,641 | 563,000 | 0.38% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 82,675 | 553,000 | 0.38% | ||
| 45 | Spark Investment Management LLC | 78,100 | 520,000 | 0.36% | ||
| 46 | ALGERT GLOBAL LLC | 73,181 | 490,000 | 0.33% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,600 | 472,000 | 0.32% | Call | |
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 67,642 | 453,000 | 0.31% | ||
| 49 | WELLS FARGO & COMPANY/MN | 67,074 | 449,000 | 0.31% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 63,186 | 423,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
