| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,954,259 | 19,852,000 | 13.97% | ||
| 2 | LANSDOWNE PARTNERS (UK) LLP | 2,321,865 | 15,603,000 | 10.98% | ||
| 3 | BVF INC/IL | 2,106,989 | 14,159,000 | 9.96% | ||
| 4 | BlackRock Institutional Trust Company, N.A. | 1,438,555 | 9,667,000 | 6.80% | ||
| 5 | VANGUARD GROUP INC | 1,135,452 | 7,630,000 | 5.37% | ||
| 6 | TFS CAPITAL LLC | 899,951 | 6,048,000 | 4.25% | ||
| 7 | BlackRock Fund Advisors | 898,910 | 6,041,000 | 4.25% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 648,564 | 4,358,000 | 3.07% | ||
| 9 | D. E. Shaw & Co., Inc. | 594,416 | 3,995,000 | 2.81% | ||
| 10 | TEACHERS ADVISORS, LLC | 562,925 | 3,783,000 | 2.66% | ||
| 11 | STATE STREET CORP | 549,615 | 3,694,000 | 2.60% | ||
| 12 | WASATCH ADVISORS LP | 547,779 | 3,681,000 | 2.59% | ||
| 13 | IRONWOOD INVESTMENT MANAGEMENT LLC | 435,202 | 2,925,000 | 2.06% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 422,250 | 2,838,000 | 2.00% | ||
| 15 | MORGAN STANLEY | 375,188 | 2,522,000 | 1.77% | ||
| 16 | Numeric Investors LLC | 374,108 | 2,514,000 | 1.77% | ||
| 17 | NORTHERN TRUST CORP | 332,977 | 2,238,000 | 1.57% | ||
| 18 | First Light Asset Management, LLC | 218,792 | 1,470,000 | 1.03% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 196,478 | 1,320,000 | 0.93% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 194,125 | 1,305,000 | 0.92% | ||
| 21 | OXFORD ASSET MANAGEMENT LLP | 192,687 | 1,295,000 | 0.91% | ||
| 22 | PANAGORA ASSET MANAGEMENT INC | 176,610 | 1,187,000 | 0.84% | ||
| 23 | BLACKROCK ADVISORS LLC | 174,596 | 1,173,000 | 0.83% | ||
| 24 | Bank of New York Mellon Corp | 169,346 | 1,137,000 | 0.80% | ||
| 25 | PDT Partners, LLC | 159,500 | 1,072,000 | 0.75% | ||
| 26 | ACADIAN ASSET MANAGEMENT LLC | 130,814 | 879,000 | 0.62% | ||
| 27 | BlackRock Investment Management, LLC | 129,536 | 870,000 | 0.61% | ||
| 28 | Palo Alto Investors LP | 123,686 | 831,000 | 0.58% | ||
| 29 | DIMENSIONAL FUND ADVISORS LP | 116,661 | 784,000 | 0.55% | ||
| 30 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 115,379 | 775,000 | 0.55% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 110,000 | 739,000 | 0.52% | Call | |
| 32 | STRS OHIO | 104,400 | 701,000 | 0.49% | ||
| 33 | Healthcare Value Capital, LLC | 100,000 | 672,000 | 0.47% | ||
| 34 | DEUTSCHE BANK AG\ | 99,810 | 669,000 | 0.47% | ||
| 35 | Nine Chapters Capital Management LLC | 99,300 | 667,000 | 0.47% | ||
| 36 | Nationwide Fund Advisors | 96,128 | 646,000 | 0.45% | ||
| 37 | Creative Planning | 93,109 | 626,000 | 0.44% | ||
| 38 | STONERIDGE INVESTMENT PARTNERS LLC | 89,176 | 599,000 | 0.42% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 82,675 | 556,000 | 0.39% | ||
| 40 | EAGLE GLOBAL ADVISORS LLC | 76,610 | 515,000 | 0.36% | ||
| 41 | GOLDMAN SACHS GROUP INC | 75,000 | 504,000 | 0.35% | Call | |
| 42 | GOLDMAN SACHS GROUP INC | 75,000 | 504,000 | 0.35% | Put | |
| 43 | ALGERT GLOBAL LLC | 73,181 | 492,000 | 0.35% | ||
| 44 | RENAISSANCE TECHNOLOGIES LLC | 72,400 | 487,000 | 0.34% | ||
| 45 | JACOBS LEVY EQUITY MANAGEMENT, INC | 70,746 | 475,000 | 0.33% | ||
| 46 | WELLS FARGO & COMPANY/MN | 64,577 | 434,000 | 0.31% | ||
| 47 | NEW YORK STATE COMMON RETIREMENT FUND | 64,477 | 433,000 | 0.30% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 63,186 | 425,000 | 0.30% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 58,100 | 390,000 | 0.27% | Call | |
| 50 | Trexquant Investment LP | 56,300 | 378,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
