| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,878,038 | 19,513,000 | 14.48% | ||
| 2 | LANSDOWNE PARTNERS (UK) LLP | 2,321,865 | 15,742,000 | 11.68% | ||
| 3 | BVF INC/IL | 2,106,989 | 14,285,000 | 10.60% | ||
| 4 | BlackRock Institutional Trust Company, N.A. | 1,466,439 | 9,942,000 | 7.38% | ||
| 5 | VANGUARD GROUP INC | 1,115,341 | 7,562,000 | 5.61% | ||
| 6 | BlackRock Fund Advisors | 945,528 | 6,411,000 | 4.76% | ||
| 7 | D. E. Shaw & Co., Inc. | 731,445 | 4,959,000 | 3.68% | ||
| 8 | IRONWOOD INVESTMENT MANAGEMENT LLC | 610,933 | 4,142,000 | 3.07% | ||
| 9 | TEACHERS ADVISORS, LLC | 562,749 | 3,815,000 | 2.83% | ||
| 10 | WASATCH ADVISORS LP | 549,030 | 3,722,000 | 2.76% | ||
| 11 | STATE STREET CORP | 535,333 | 3,629,000 | 2.69% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 468,178 | 3,174,000 | 2.36% | ||
| 13 | MORGAN STANLEY | 358,697 | 2,432,000 | 1.81% | ||
| 14 | NORTHERN TRUST CORP | 330,875 | 2,243,000 | 1.66% | ||
| 15 | Numeric Investors LLC | 277,741 | 1,883,000 | 1.40% | ||
| 16 | BLACKROCK ADVISORS LLC | 243,562 | 1,651,000 | 1.23% | ||
| 17 | First Light Asset Management, LLC | 199,014 | 1,349,000 | 1.00% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 195,076 | 1,322,000 | 0.98% | ||
| 19 | CITADEL ADVISORS LLC | 181,362 | 1,230,000 | 0.91% | ||
| 20 | TFS CAPITAL LLC | 180,666 | 1,225,000 | 0.91% | ||
| 21 | Nine Chapters Capital Management LLC | 174,700 | 1,184,000 | 0.88% | ||
| 22 | Bank of New York Mellon Corp | 169,184 | 1,147,000 | 0.85% | ||
| 23 | GSA CAPITAL PARTNERS LLP | 167,074 | 1,133,000 | 0.84% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 158,389 | 1,074,000 | 0.80% | ||
| 25 | PANAGORA ASSET MANAGEMENT INC | 152,838 | 1,036,000 | 0.77% | ||
| 26 | OXFORD ASSET MANAGEMENT LLP | 134,712 | 913,000 | 0.68% | ||
| 27 | Nationwide Fund Advisors | 132,667 | 899,000 | 0.67% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 111,975 | 864,000 | 0.64% | ||
| 29 | DEUTSCHE BANK AG\ | 126,794 | 857,000 | 0.64% | ||
| 30 | Palo Alto Investors LP | 123,686 | 839,000 | 0.62% | ||
| 31 | DIMENSIONAL FUND ADVISORS LP | 117,747 | 798,000 | 0.59% | ||
| 32 | JACOBS LEVY EQUITY MANAGEMENT, INC | 116,246 | 788,000 | 0.58% | ||
| 33 | BlackRock Investment Management, LLC | 114,474 | 776,000 | 0.58% | ||
| 34 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 110,169 | 746,000 | 0.55% | ||
| 35 | Healthcare Value Capital, LLC | 100,000 | 678,000 | 0.50% | ||
| 36 | RUSSELL FRANK CO/ | 92,933 | 630,000 | 0.47% | ||
| 37 | GOLDMAN SACHS GROUP INC | 75,000 | 509,000 | 0.38% | Put | |
| 38 | GOLDMAN SACHS GROUP INC | 75,000 | 509,000 | 0.38% | Call | |
| 39 | PDT Partners, LLC | 73,600 | 499,000 | 0.37% | ||
| 40 | ALGERT GLOBAL LLC | 73,181 | 496,000 | 0.37% | ||
| 41 | RENAISSANCE TECHNOLOGIES LLC | 69,467 | 471,000 | 0.35% | ||
| 42 | STONERIDGE INVESTMENT PARTNERS LLC | 63,307 | 429,000 | 0.32% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 62,898 | 426,000 | 0.32% | ||
| 44 | STRS OHIO | 58,600 | 397,000 | 0.29% | ||
| 45 | KEYBANK NATIONAL ASSOCIATION/OH | 53,645 | 364,000 | 0.27% | ||
| 46 | WELLS FARGO & COMPANY/MN | 51,674 | 350,000 | 0.26% | ||
| 47 | Alyeska Investment Group, L.P. | 50,607 | 343,000 | 0.25% | Call | |
| 48 | RHUMBLINE ADVISERS | 46,630 | 316,000 | 0.23% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,900 | 312,000 | 0.23% | ||
| 50 | Alyeska Investment Group, L.P. | 40,485 | 274,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
