| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,199,414 | 63,173,000 | 19.65% | ||
| 2 | BVF INC/IL | 4,851,691 | 58,948,000 | 18.34% | ||
| 3 | LANSDOWNE PARTNERS (UK) LLP | 2,321,865 | 28,211,000 | 8.77% | ||
| 4 | VANGUARD GROUP INC | 1,681,908 | 20,435,000 | 6.36% | ||
| 5 | WASATCH ADVISORS LP | 1,671,615 | 20,310,000 | 6.32% | ||
| 6 | BlackRock Fund Advisors | 1,633,726 | 19,850,000 | 6.17% | ||
| 7 | WELLINGTON MANAGEMENT GROUP LLP | 1,396,523 | 16,967,000 | 5.28% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,103,756 | 13,411,000 | 4.17% | ||
| 9 | STATE STREET CORP | 897,748 | 10,908,000 | 3.39% | ||
| 10 | CITIGROUP INC | 749,759 | 9,110,000 | 2.83% | ||
| 11 | NORTHERN TRUST CORP | 374,782 | 4,554,000 | 1.42% | ||
| 12 | BALYASNY ASSET MANAGEMENT L.P. | 325,575 | 3,956,000 | 1.23% | ||
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 284,936 | 3,461,000 | 1.08% | ||
| 14 | D. E. Shaw & Co., Inc. | 253,520 | 3,080,000 | 0.96% | ||
| 15 | MORGAN STANLEY | 215,282 | 2,615,000 | 0.81% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 211,486 | 2,570,000 | 0.80% | ||
| 17 | DAFNA Capital Management LLC | 210,306 | 2,555,000 | 0.79% | ||
| 18 | PNC FINANCIAL SERVICES GROUP, INC. | 169,216 | 2,056,000 | 0.64% | ||
| 19 | Bank of New York Mellon Corp | 164,479 | 1,998,000 | 0.62% | ||
| 20 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 163,260 | 1,984,000 | 0.62% | ||
| 21 | GLOBEFLEX CAPITAL L P | 139,065 | 1,690,000 | 0.53% | ||
| 22 | BlackRock Investment Management, LLC | 134,303 | 1,632,000 | 0.51% | ||
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 127,442 | 1,549,000 | 0.48% | ||
| 24 | BLACKROCK ADVISORS LLC | 123,763 | 1,504,000 | 0.47% | ||
| 25 | Palo Alto Investors LP | 123,686 | 1,503,000 | 0.47% | ||
| 26 | IRONWOOD INVESTMENT MANAGEMENT LLC | 121,360 | 1,475,000 | 0.46% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 98,386 | 1,195,000 | 0.37% | ||
| 28 | DEUTSCHE BANK AG\ | 97,705 | 1,185,000 | 0.37% | ||
| 29 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 90,500 | 1,098,000 | 0.34% | ||
| 30 | ClariVest Asset Management LLC | 89,176 | 1,084,000 | 0.34% | ||
| 31 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 82,675 | 1,005,000 | 0.31% | ||
| 32 | NORGES BANK | 80,321 | 976,000 | 0.30% | ||
| 33 | GOLDMAN SACHS GROUP INC | 71,491 | 869,000 | 0.27% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 69,808 | 848,000 | 0.26% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 62,737 | 762,000 | 0.24% | ||
| 36 | EcoR1 Capital, LLC | 54,879 | 667,000 | 0.21% | ||
| 37 | TEACHERS ADVISORS, LLC | 53,278 | 647,000 | 0.20% | ||
| 38 | TWO SIGMA ADVISERS, LP | 49,400 | 600,000 | 0.19% | ||
| 39 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 51,066 | 539,000 | 0.17% | ||
| 40 | CUTLER GROUP LLC / CA | 43,352 | 526,000 | 0.16% | ||
| 41 | KEYBANK NATIONAL ASSOCIATION/OH | 40,204 | 488,000 | 0.15% | ||
| 42 | RHUMBLINE ADVISERS | 37,997 | 462,000 | 0.14% | ||
| 43 | A.R.T. Advisors, LLC | 32,461 | 394,000 | 0.12% | ||
| 44 | ProShare Advisors LLC | 32,207 | 391,000 | 0.12% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 31,700 | 385,000 | 0.12% | ||
| 46 | METROPOLITAN LIFE INSURANCE CO/NY | 27,453 | 334,000 | 0.10% | ||
| 47 | WELLS FARGO & COMPANY/MN | 26,766 | 325,000 | 0.10% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 26,500 | 322,000 | 0.10% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,176 | 294,000 | 0.09% | ||
| 50 | VIRTUS ETF ADVISERS LLC | 22,494 | 273,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
