| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 4,989,218 | 47,348,000 | 18.72% | ||
| 2 | FMR LLC | 3,307,822 | 31,391,000 | 12.41% | ||
| 3 | LANSDOWNE PARTNERS (UK) LLP | 2,321,865 | 22,034,000 | 8.71% | ||
| 4 | EcoR1 Capital, LLC | 2,139,697 | 20,306,000 | 8.03% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 1,807,381 | 17,152,000 | 6.78% | ||
| 6 | VANGUARD GROUP INC | 1,804,613 | 17,125,000 | 6.77% | ||
| 7 | WASATCH ADVISORS LP | 1,746,096 | 16,570,000 | 6.55% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,109,213 | 10,526,000 | 4.16% | ||
| 9 | BlackRock Fund Advisors | 881,984 | 8,370,000 | 3.31% | ||
| 10 | CITIGROUP INC | 711,819 | 6,755,000 | 2.67% | ||
| 11 | STATE STREET CORP | 623,246 | 5,911,000 | 2.34% | ||
| 12 | Avoro Capital Advisors LLC | 503,900 | 4,782,000 | 1.89% | ||
| 13 | ACADIAN ASSET MANAGEMENT LLC | 334,284 | 3,172,000 | 1.25% | ||
| 14 | D. E. Shaw & Co., Inc. | 304,680 | 2,892,000 | 1.14% | ||
| 15 | NORTHERN TRUST CORP | 303,986 | 2,885,000 | 1.14% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 271,851 | 2,579,000 | 1.02% | ||
| 17 | PNC FINANCIAL SERVICES GROUP, INC. | 221,522 | 2,104,000 | 0.83% | ||
| 18 | Bank of New York Mellon Corp | 164,901 | 1,565,000 | 0.62% | ||
| 19 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 159,560 | 1,514,000 | 0.60% | ||
| 20 | IRONWOOD INVESTMENT MANAGEMENT LLC | 151,106 | 1,434,000 | 0.57% | ||
| 21 | DAFNA Capital Management LLC | 150,000 | 1,424,000 | 0.56% | ||
| 22 | Iguana Healthcare Management, LLC | 150,000 | 1,424,000 | 0.56% | ||
| 23 | ACUTA CAPITAL PARTNERS, LLC | 140,969 | 1,338,000 | 0.53% | ||
| 24 | BlackRock Investment Management, LLC | 129,386 | 1,228,000 | 0.49% | ||
| 25 | EMERALD ACQUISITION LTD. | 128,133 | 1,216,000 | 0.48% | ||
| 26 | Palo Alto Investors LP | 123,686 | 1,174,000 | 0.46% | ||
| 27 | BLACKROCK ADVISORS LLC | 121,700 | 1,155,000 | 0.46% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 108,932 | 1,034,000 | 0.41% | ||
| 29 | GOLDMAN SACHS GROUP INC | 102,839 | 976,000 | 0.39% | ||
| 30 | Healthcare Value Capital, LLC | 100,000 | 949,000 | 0.38% | ||
| 31 | ClariVest Asset Management LLC | 89,263 | 847,000 | 0.33% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 82,675 | 785,000 | 0.31% | ||
| 33 | PANAGORA ASSET MANAGEMENT INC | 76,805 | 729,000 | 0.29% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 71,008 | 674,000 | 0.27% | ||
| 35 | STRS OHIO | 64,900 | 615,000 | 0.24% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 63,600 | 604,000 | 0.24% | Call | |
| 37 | DEUTSCHE BANK AG\ | 63,313 | 599,000 | 0.24% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 57,100 | 542,000 | 0.21% | ||
| 39 | PRUDENTIAL FINANCIAL INC | 55,500 | 527,000 | 0.21% | ||
| 40 | TEACHERS ADVISORS, LLC | 51,253 | 486,000 | 0.19% | ||
| 41 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 51,066 | 485,000 | 0.19% | ||
| 42 | Matarin Capital Management, LLC | 44,720 | 424,393 | 0.17% | ||
| 43 | KEYBANK NATIONAL ASSOCIATION/OH | 44,168 | 419,000 | 0.17% | ||
| 44 | TWO SIGMA ADVISERS, LP | 43,900 | 417,000 | 0.16% | ||
| 45 | RHUMBLINE ADVISERS | 40,695 | 386,000 | 0.15% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 39,069 | 371,000 | 0.15% | ||
| 47 | SPHERA FUNDS MANAGEMENT LTD. | 32,069 | 304,000 | 0.12% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31,800 | 302,000 | 0.12% | Put | |
| 49 | VIRTUS ETF ADVISERS LLC | 29,379 | 279,000 | 0.11% | ||
| 50 | METROPOLITAN LIFE INSURANCE CO/NY | 27,453 | 261,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
