| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 2,920,628 | 30,550,000 | 10.95% | ||
| 2 | LANSDOWNE PARTNERS (UK) LLP | 2,321,865 | 24,287,000 | 8.71% | ||
| 3 | FMR LLC | 2,148,197 | 22,470,000 | 8.05% | ||
| 4 | EcoR1 Capital, LLC | 1,418,700 | 14,840,000 | 5.32% | ||
| 5 | BlackRock Institutional Trust Company, N.A. | 1,313,501 | 13,739,000 | 4.92% | ||
| 6 | VANGUARD GROUP INC | 1,284,618 | 13,437,000 | 4.82% | ||
| 7 | ACADIAN ASSET MANAGEMENT LLC | 1,170,312 | 12,239,000 | 4.39% | ||
| 8 | BlackRock Fund Advisors | 919,488 | 9,618,000 | 3.45% | ||
| 9 | STATE STREET CORP | 801,211 | 8,380,000 | 3.00% | ||
| 10 | CITIGROUP INC | 722,576 | 7,558,000 | 2.71% | ||
| 11 | TEACHERS ADVISORS, LLC | 601,240 | 6,289,000 | 2.25% | ||
| 12 | RENAISSANCE TECHNOLOGIES LLC | 519,278 | 5,432,000 | 1.95% | ||
| 13 | WASATCH ADVISORS LP | 478,890 | 5,009,000 | 1.80% | ||
| 14 | RUSSELL FRANK CO/ | 448,998 | 4,719,000 | 1.69% | ||
| 15 | Informed Momentum Co LLC | 419,472 | 4,388,000 | 1.57% | ||
| 16 | D. E. Shaw & Co., Inc. | 384,540 | 4,022,000 | 1.44% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 379,582 | 3,970,000 | 1.42% | ||
| 18 | Invesco Ltd. | 379,459 | 3,969,000 | 1.42% | ||
| 19 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 377,801 | 3,951,000 | 1.42% | ||
| 20 | NORTHERN TRUST CORP | 373,343 | 3,906,000 | 1.40% | ||
| 21 | Iguana Healthcare Management, LLC | 350,000 | 3,661,000 | 1.31% | ||
| 22 | Numeric Investors LLC | 349,452 | 3,655,000 | 1.31% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 326,080 | 3,409,000 | 1.22% | ||
| 24 | TWO SIGMA INVESTMENTS, LP | 320,394 | 3,351,000 | 1.20% | ||
| 25 | PRUDENTIAL FINANCIAL INC | 258,200 | 2,701,000 | 0.97% | ||
| 26 | WELLINGTON MANAGEMENT GROUP LLP | 256,665 | 2,685,000 | 0.96% | ||
| 27 | IRONWOOD INVESTMENT MANAGEMENT LLC | 250,005 | 2,615,000 | 0.94% | ||
| 28 | Matarin Capital Management, LLC | 240,163 | 2,512,105 | 0.90% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 239,545 | 2,506,000 | 0.90% | ||
| 30 | BALYASNY ASSET MANAGEMENT L.P. | 232,430 | 2,431,000 | 0.87% | ||
| 31 | Bank of New York Mellon Corp | 229,936 | 2,406,000 | 0.86% | ||
| 32 | PANAGORA ASSET MANAGEMENT INC | 206,523 | 2,160,000 | 0.77% | ||
| 33 | AMERIPRISE FINANCIAL INC | 194,179 | 2,031,000 | 0.73% | ||
| 34 | PDT Partners, LLC | 171,000 | 1,789,000 | 0.64% | ||
| 35 | SMITH ASSET MANAGEMENT GROUP LP | 155,670 | 1,628,000 | 0.58% | ||
| 36 | OXFORD ASSET MANAGEMENT LLP | 147,812 | 1,550,000 | 0.56% | ||
| 37 | Spark Investment Management LLC | 143,200 | 1,497,000 | 0.54% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 132,800 | 1,389,000 | 0.50% | Call | |
| 39 | BlackRock Investment Management, LLC | 127,055 | 1,329,000 | 0.48% | ||
| 40 | Freedom Investment Management, Inc. | 126,455 | 1,323,000 | 0.47% | ||
| 41 | Palo Alto Investors LP | 123,686 | 1,294,000 | 0.46% | ||
| 42 | BLACKROCK ADVISORS LLC | 122,128 | 1,277,000 | 0.46% | ||
| 43 | MORGAN STANLEY | 121,646 | 1,272,000 | 0.46% | ||
| 44 | GSA CAPITAL PARTNERS LLP | 117,931 | 1,234,000 | 0.44% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 117,575 | 1,230,000 | 0.44% | ||
| 46 | GREAT POINT PARTNERS LLC | 106,800 | 1,117,000 | 0.40% | Put | |
| 47 | ClariVest Asset Management LLC | 100,991 | 1,056,000 | 0.38% | ||
| 48 | Healthcare Value Capital, LLC | 100,000 | 1,046,000 | 0.37% | ||
| 49 | Asset Management One Co., Ltd. | 88,124 | 922,000 | 0.33% | ||
| 50 | A.R.T. Advisors, LLC | 84,797 | 886,000 | 0.32% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
