| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,062,656 | 46,475,000 | 18.79% | ||
| 2 | BVF INC/IL | 4,997,071 | 45,873,000 | 18.55% | ||
| 3 | LANSDOWNE PARTNERS (UK) LLP | 2,321,865 | 21,315,000 | 8.62% | ||
| 4 | VANGUARD GROUP INC | 1,797,337 | 16,499,000 | 6.67% | ||
| 5 | WASATCH ADVISORS LP | 1,723,160 | 15,819,000 | 6.40% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 1,606,040 | 14,744,000 | 5.96% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 1,087,759 | 9,986,000 | 4.04% | ||
| 8 | STATE STREET CORP | 973,200 | 8,936,000 | 3.61% | ||
| 9 | BlackRock Fund Advisors | 934,027 | 8,574,000 | 3.47% | ||
| 10 | EcoR1 Capital, LLC | 846,654 | 7,772,000 | 3.14% | ||
| 11 | CITIGROUP INC | 708,038 | 6,499,000 | 2.63% | ||
| 12 | NORTHERN TRUST CORP | 356,547 | 3,273,000 | 1.32% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 312,200 | 2,866,000 | 1.16% | ||
| 14 | D. E. Shaw & Co., Inc. | 310,959 | 2,855,000 | 1.15% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 273,668 | 2,512,000 | 1.02% | ||
| 16 | DAFNA Capital Management LLC | 181,737 | 1,668,000 | 0.67% | ||
| 17 | PNC FINANCIAL SERVICES GROUP, INC. | 173,794 | 1,596,000 | 0.65% | ||
| 18 | Bank of New York Mellon Corp | 160,341 | 1,472,000 | 0.60% | ||
| 19 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 159,180 | 1,461,000 | 0.59% | ||
| 20 | BlackRock Investment Management, LLC | 134,826 | 1,238,000 | 0.50% | ||
| 21 | IRONWOOD INVESTMENT MANAGEMENT LLC | 133,509 | 1,226,000 | 0.50% | ||
| 22 | GOLDMAN SACHS GROUP INC | 133,362 | 1,224,000 | 0.49% | ||
| 23 | DEUTSCHE BANK AG\ | 130,514 | 1,197,000 | 0.48% | ||
| 24 | Palo Alto Investors LP | 123,686 | 1,135,000 | 0.46% | ||
| 25 | BLACKROCK ADVISORS LLC | 122,815 | 1,127,000 | 0.46% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,204 | 1,104,000 | 0.45% | ||
| 27 | Belmont Global Advisors, Inc. | 120,000 | 1,102,000 | 0.45% | Call | |
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 108,352 | 995,000 | 0.40% | ||
| 29 | Healthcare Value Capital, LLC | 100,000 | 918,000 | 0.37% | ||
| 30 | Invesco Ltd. | 99,989 | 918,000 | 0.37% | ||
| 31 | PANAGORA ASSET MANAGEMENT INC | 94,338 | 866,000 | 0.35% | ||
| 32 | TWO SIGMA ADVISERS, LP | 89,700 | 823,000 | 0.33% | ||
| 33 | ClariVest Asset Management LLC | 89,263 | 820,000 | 0.33% | ||
| 34 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 82,675 | 759,000 | 0.31% | ||
| 35 | TWO SIGMA INVESTMENTS, LP | 78,710 | 723,000 | 0.29% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 71,508 | 656,000 | 0.27% | ||
| 37 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 59,075 | 543,000 | 0.22% | ||
| 38 | MORGAN STANLEY | 53,638 | 493,000 | 0.20% | ||
| 39 | TEACHERS ADVISORS, LLC | 51,253 | 471,000 | 0.19% | ||
| 40 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 51,066 | 469,000 | 0.19% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,900 | 467,000 | 0.19% | Call | |
| 42 | KEYBANK NATIONAL ASSOCIATION/OH | 44,168 | 405,000 | 0.16% | ||
| 43 | TUDOR INVESTMENT CORP ET AL | 41,300 | 379,000 | 0.15% | ||
| 44 | CITADEL ADVISORS LLC | 41,046 | 377,000 | 0.15% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 37,000 | 340,000 | 0.14% | Put | |
| 46 | RHUMBLINE ADVISERS | 34,835 | 320,000 | 0.13% | ||
| 47 | CROSSMARK GLOBAL HOLDINGS, INC. | 21,460 | 311,000 | 0.13% | ||
| 48 | CREDIT SUISSE AG/ | 32,311 | 297,000 | 0.12% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 31,700 | 291,000 | 0.12% | ||
| 50 | VIRTUS ETF ADVISERS LLC | 29,379 | 270,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
