| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 4,407,317 | 94,096,000 | 15.88% | ||
| 2 | FMR LLC | 3,891,876 | 83,092,000 | 14.02% | ||
| 3 | BlackRock Finance, Inc. | 2,368,461 | 50,567,000 | 8.53% | ||
| 4 | Aisling Capital LLC | 2,024,465 | 43,222,000 | 7.29% | ||
| 5 | BAKER BROS. ADVISORS LP | 1,660,593 | 35,454,000 | 5.98% | ||
| 6 | SOFINNOVA MANAGEMENT VIII, L.L.C. | 1,563,260 | 33,376,000 | 5.63% | ||
| 7 | FEDERATED HERMES, INC. | 1,452,623 | 31,013,000 | 5.23% | ||
| 8 | New Leaf Venture Partners, L.L.C. | 1,448,296 | 30,921,000 | 5.22% | ||
| 9 | JPMORGAN CHASE & CO | 1,019,579 | 21,768,000 | 3.67% | ||
| 10 | VANGUARD GROUP INC | 1,002,507 | 21,404,000 | 3.61% | ||
| 11 | STATE STREET CORP | 520,761 | 11,118,000 | 1.88% | ||
| 12 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 372,069 | 7,944,000 | 1.34% | ||
| 13 | NORTHERN TRUST CORP | 363,792 | 7,767,000 | 1.31% | ||
| 14 | Artal Group S.A. | 300,000 | 6,405,000 | 1.08% | ||
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 300,000 | 6,405,000 | 1.08% | ||
| 16 | ArrowMark Colorado Holdings LLC | 290,140 | 6,194,000 | 1.05% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 257,417 | 5,495,000 | 0.93% | ||
| 18 | LORD, ABBETT & CO. LLC | 252,877 | 5,399,000 | 0.91% | ||
| 19 | NF TRINITY CAPITAL (HONG KONG) LTD | 244,897 | 5,229,000 | 0.88% | ||
| 20 | RENAISSANCE TECHNOLOGIES LLC | 214,700 | 4,584,000 | 0.77% | ||
| 21 | DRIEHAUS CAPITAL MANAGEMENT LLC | 192,838 | 4,117,000 | 0.69% | ||
| 22 | PRINCIPAL FINANCIAL GROUP INC | 187,600 | 4,005,000 | 0.68% | ||
| 23 | ISZO CAPITAL MANAGEMENT LP | 186,399 | 3,980,000 | 0.67% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 177,136 | 3,782,000 | 0.64% | ||
| 25 | Bank of New York Mellon Corp | 164,247 | 3,506,000 | 0.59% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 156,371 | 3,339,000 | 0.56% | ||
| 27 | SCHONFELD STRATEGIC ADVISORS LLC | 140,734 | 3,005,000 | 0.51% | ||
| 28 | OXFORD ASSET MANAGEMENT LLP | 124,744 | 2,663,000 | 0.45% | ||
| 29 | ClariVest Asset Management LLC | 116,168 | 2,480,000 | 0.42% | ||
| 30 | DLD ASSET MANAGEMENT, LP | 109,400 | 2,334,000 | 0.39% | Call | |
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 108,782 | 2,323,000 | 0.39% | ||
| 32 | GOLDMAN SACHS GROUP INC | 100,784 | 2,152,000 | 0.36% | ||
| 33 | EcoR1 Capital, LLC | 100,000 | 2,135,000 | 0.36% | ||
| 34 | TWO SIGMA INVESTMENTS, LP | 94,254 | 2,012,000 | 0.34% | ||
| 35 | PointState Capital LP | 83,417 | 1,781,000 | 0.30% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71,300 | 1,522,000 | 0.26% | Call | |
| 37 | NEW YORK STATE COMMON RETIREMENT FUND | 67,416 | 1,439,000 | 0.24% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 67,200 | 1,435,000 | 0.24% | Put | |
| 39 | Spark Investment Management LLC | 63,300 | 1,351,000 | 0.23% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 61,695 | 1,317,000 | 0.22% | ||
| 41 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 56,327 | 1,202,000 | 0.20% | ||
| 42 | TEACHERS ADVISORS, LLC | 55,244 | 1,179,000 | 0.20% | ||
| 43 | MORGAN STANLEY | 54,278 | 1,159,000 | 0.20% | ||
| 44 | ACUTA CAPITAL PARTNERS, LLC | 49,100 | 1,048,000 | 0.18% | Put | |
| 45 | ALLIANCEBERNSTEIN L.P. | 47,130 | 1,006,000 | 0.17% | ||
| 46 | CITADEL ADVISORS LLC | 44,469 | 950,000 | 0.16% | ||
| 47 | Nationwide Fund Advisors | 44,159 | 943,000 | 0.16% | ||
| 48 | HAMILTON LANE ADVISORS LLC | 43,032 | 919,000 | 0.16% | ||
| 49 | WELLS FARGO & COMPANY/MN | 40,779 | 871,000 | 0.15% | ||
| 50 | Swiss National Bank | 40,200 | 858,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
