| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,180,700 | 148,337,000 | 17.96% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 6,023,605 | 144,567,000 | 17.50% | ||
| 3 | NEA Management Company, LLC | 5,149,740 | 123,594,000 | 14.96% | ||
| 4 | MPM ASSET MANAGEMENT LLC | 1,781,086 | 42,746,000 | 5.18% | ||
| 5 | EcoR1 Capital, LLC | 1,685,800 | 40,459,000 | 4.90% | ||
| 6 | STATE STREET CORP | 1,674,344 | 40,180,000 | 4.86% | ||
| 7 | VANGUARD GROUP INC | 1,616,340 | 38,793,000 | 4.70% | ||
| 8 | BlackRock Fund Advisors | 1,222,731 | 29,346,000 | 3.55% | ||
| 9 | Foresite Capital Management II, LLC | 897,863 | 21,549,000 | 2.61% | ||
| 10 | BALYASNY ASSET MANAGEMENT L.P. | 861,627 | 20,679,000 | 2.50% | ||
| 11 | QVT Financial LP | 610,442 | 14,651,000 | 1.77% | ||
| 12 | Point72 Asset Management, L.P. | 482,100 | 11,570,000 | 1.40% | ||
| 13 | NORGES BANK | 431,395 | 10,353,000 | 1.25% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 367,531 | 8,821,000 | 1.07% | ||
| 15 | LORD, ABBETT & CO. LLC | 328,871 | 7,892,000 | 0.96% | ||
| 16 | Allianz Asset Management GmbH | 311,000 | 7,464,000 | 0.90% | ||
| 17 | Rock Springs Capital Management LP | 306,500 | 7,356,000 | 0.89% | ||
| 18 | Cormorant Asset Management, LP | 266,250 | 6,390,000 | 0.77% | ||
| 19 | JENNISON ASSOCIATES LLC | 252,117 | 6,051,000 | 0.73% | ||
| 20 | Ghost Tree Capital, LLC | 250,000 | 6,000,000 | 0.73% | ||
| 21 | BAKER BROS. ADVISORS LP | 232,481 | 5,580,000 | 0.68% | ||
| 22 | NORTHERN TRUST CORP | 210,815 | 5,060,000 | 0.61% | ||
| 23 | GOLDMAN SACHS GROUP INC | 209,413 | 5,026,000 | 0.61% | ||
| 24 | Tekla Capital Management LLC | 200,000 | 4,800,000 | 0.58% | ||
| 25 | Candriam S.C.A. | 162,000 | 3,888,000 | 0.47% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 159,767 | 3,834,000 | 0.46% | ||
| 27 | Alyeska Investment Group, L.P. | 153,124 | 3,675,000 | 0.44% | ||
| 28 | Bank of New York Mellon Corp | 137,755 | 3,307,000 | 0.40% | ||
| 29 | Rhenman & Partners Asset Management AB | 131,785 | 3,163,000 | 0.38% | ||
| 30 | DEUTSCHE BANK AG\ | 103,138 | 2,473,000 | 0.30% | ||
| 31 | WELLINGTON MANAGEMENT GROUP LLP | 101,963 | 2,447,000 | 0.30% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 99,473 | 2,387,000 | 0.29% | ||
| 33 | BlackRock Investment Management, LLC | 97,769 | 2,346,000 | 0.28% | ||
| 34 | QS Investors, LLC | 94,526 | 2,269,000 | 0.27% | ||
| 35 | CREDIT SUISSE AG/ | 92,321 | 2,216,000 | 0.27% | ||
| 36 | PRINCIPAL FINANCIAL GROUP INC | 81,763 | 1,962,000 | 0.24% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 73,334 | 1,761,000 | 0.21% | ||
| 38 | Opus Point Partners Management, LLC | 72,379 | 1,737,000 | 0.21% | ||
| 39 | NEW YORK STATE COMMON RETIREMENT FUND | 67,804 | 1,627,000 | 0.20% | ||
| 40 | STONERIDGE INVESTMENT PARTNERS LLC | 67,787 | 1,627,000 | 0.20% | ||
| 41 | Iguana Healthcare Management, LLC | 65,000 | 1,560,000 | 0.19% | ||
| 42 | TURNER INVESTMENTS LLC | 62,790 | 1,507,000 | 0.18% | ||
| 43 | Palo Alto Investors LP | 61,265 | 1,470,000 | 0.18% | ||
| 44 | PERCEPTIVE ADVISORS LLC | 60,000 | 1,440,000 | 0.17% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,049 | 1,273,000 | 0.15% | ||
| 46 | MUHLENKAMP & CO INC | 51,860 | 1,245,000 | 0.15% | ||
| 47 | MILLENNIUM MANAGEMENT LLC | 50,000 | 1,200,000 | 0.15% | ||
| 48 | MARSHALL WACE, LLP | 49,979 | 1,199,000 | 0.15% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 45,200 | 1,085,000 | 0.13% | ||
| 50 | Granite Point Capital Management, L.P. | 45,000 | 1,080,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
