| 1 |
FMR LLC |
3,053,673 |
29,743,000 |
32.04% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
2,473,186 |
24,089,000 |
25.95% |
|
|
| 3 |
WELLINGTON MANAGEMENT GROUP LLP |
1,121,180 |
10,920,000 |
11.76% |
|
|
| 4 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
1,113,475 |
10,533,000 |
11.35% |
|
|
| 5 |
ORBIMED ADVISORS LLC |
692,900 |
6,749,000 |
7.27% |
|
|
| 6 |
Board of Trustees of The Leland Stanford Junior University |
303,538 |
2,956,000 |
3.18% |
|
|
| 7 |
FARALLON CAPITAL MANAGEMENT LLC |
275,000 |
2,679,000 |
2.89% |
|
|
| 8 |
PRINCIPAL FINANCIAL GROUP INC |
204,000 |
1,987,000 |
2.14% |
|
|
| 9 |
VANGUARD GROUP INC |
148,606 |
1,447,000 |
1.56% |
|
|
| 10 |
Bank of New York Mellon Corp |
38,400 |
374,000 |
0.40% |
|
|
| 11 |
GOLDMAN SACHS GROUP INC |
26,310 |
256,000 |
0.28% |
|
|
| 12 |
UBS AG |
25,662 |
250,000 |
0.27% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
23,728 |
231,000 |
0.25% |
|
|
| 14 |
BlackRock Fund Advisors |
23,151 |
225,000 |
0.24% |
|
|
| 15 |
DEUTSCHE BANK AG\ |
16,905 |
164,000 |
0.18% |
|
|
| 16 |
JANE STREET GROUP, LLC |
11,900 |
116,000 |
0.12% |
|
|
| 17 |
WELLS FARGO & COMPANY/MN |
9,949 |
97,000 |
0.10% |
|
|
| 18 |
PNC FINANCIAL SERVICES GROUP, INC. |
1,000 |
10,000 |
0.01% |
|
|
| 19 |
Tower Research Capital LLC (TRC) |
600 |
6,000 |
0.01% |
|
|
| 20 |
MORGAN STANLEY |
349 |
3,000 |
0.00% |
|
|
| 21 |
AMERICAN INTERNATIONAL GROUP, INC. |
99 |
964 |
0.00% |
|
|
