| 1 |
FMR LLC |
3,095,582 |
15,137,000 |
29.18% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
2,473,186 |
12,094,000 |
23.31% |
|
|
| 3 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
1,523,275 |
7,449,000 |
14.36% |
|
|
| 4 |
WELLINGTON MANAGEMENT GROUP LLP |
1,457,698 |
7,128,000 |
13.74% |
|
|
| 5 |
ORBIMED ADVISORS LLC |
692,900 |
3,388,000 |
6.53% |
|
|
| 6 |
HIGHLAND CAPITAL MANAGEMENT LP |
328,188 |
1,605,000 |
3.09% |
|
|
| 7 |
Board of Trustees of The Leland Stanford Junior University |
291,067 |
1,423,000 |
2.74% |
|
|
| 8 |
PRINCIPAL FINANCIAL GROUP INC |
209,600 |
1,025,000 |
1.98% |
|
|
| 9 |
VANGUARD GROUP INC |
180,638 |
883,000 |
1.70% |
|
|
| 10 |
Alyeska Investment Group, L.P. |
82,563 |
404,000 |
0.78% |
|
|
| 11 |
Broadfin Capital, LLC |
70,428 |
344,000 |
0.66% |
|
|
| 12 |
Bank of New York Mellon Corp |
38,443 |
188,000 |
0.36% |
|
|
| 13 |
GOLDMAN SACHS GROUP INC |
37,013 |
181,000 |
0.35% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
31,576 |
154,000 |
0.30% |
|
|
| 15 |
BlackRock Fund Advisors |
22,406 |
110,000 |
0.21% |
|
|
| 16 |
DAFNA Capital Management LLC |
20,190 |
99,000 |
0.19% |
|
SH |
| 17 |
RENAISSANCE TECHNOLOGIES LLC |
14,900 |
73,000 |
0.14% |
|
|
| 18 |
DEUTSCHE BANK AG\ |
14,770 |
72,000 |
0.14% |
|
|
| 19 |
Spark Investment Management LLC |
12,800 |
61,000 |
0.12% |
|
|
| 20 |
UBS Group AG |
3,443 |
17,000 |
0.03% |
|
|
| 21 |
BlackRock Investment Management, LLC |
2,179 |
11,000 |
0.02% |
|
|
| 22 |
BANK OF MONTREAL /CAN/ |
2,000 |
10,000 |
0.02% |
|
|
| 23 |
WELLS FARGO & COMPANY/MN |
2,000 |
10,000 |
0.02% |
|
|
| 24 |
MUFG Americas Holdings Corp |
980 |
5,000 |
0.01% |
|
|
| 25 |
FIRST MANHATTAN CO. LLC. |
1,000 |
4,000 |
0.01% |
|
|
