| 1 |
FRANKLIN RESOURCES INC |
6,076,879 |
15,084,000 |
26.06% |
|
|
| 2 |
FMR LLC |
4,391,885 |
11,024,000 |
19.04% |
|
|
| 3 |
BVF INC/IL |
3,759,398 |
9,436,000 |
16.30% |
|
|
| 4 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
2,615,847 |
6,566,000 |
11.34% |
|
|
| 5 |
Polaris Venture Management Co. V, L.L.C. |
2,473,186 |
6,208,000 |
10.72% |
|
|
| 6 |
Redmile Group, LLC |
1,419,058 |
3,562,000 |
6.15% |
|
|
| 7 |
VANGUARD GROUP INC |
631,995 |
1,586,000 |
2.74% |
|
|
| 8 |
MORGAN STANLEY |
557,031 |
1,398,000 |
2.42% |
|
|
| 9 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
250,000 |
628,000 |
1.08% |
|
|
| 10 |
RENAISSANCE TECHNOLOGIES LLC |
209,900 |
527,000 |
0.91% |
|
|
| 11 |
Telemetry Investments, L.L.C. |
123,500 |
310,000 |
0.54% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
115,416 |
289,000 |
0.50% |
|
|
| 13 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
93,982 |
236,000 |
0.41% |
|
|
| 14 |
BlackRock Fund Advisors |
67,239 |
169,000 |
0.29% |
|
|
| 15 |
Bank of New York Mellon Corp |
58,558 |
147,000 |
0.25% |
|
|
| 16 |
NORTHERN TRUST CORP |
39,773 |
100,000 |
0.17% |
|
|
| 17 |
PANAGORA ASSET MANAGEMENT INC |
29,510 |
74,000 |
0.13% |
|
|
| 18 |
WELLS FARGO & COMPANY/MN |
27,379 |
69,000 |
0.12% |
|
|
| 19 |
PARALLEL ADVISORS, LLC |
25,000 |
63,000 |
0.11% |
|
|
| 20 |
GOLDMAN SACHS GROUP INC |
24,853 |
62,000 |
0.11% |
|
|
| 21 |
Virtu KCG Holdings LLC |
22,716 |
57,000 |
0.10% |
|
|
| 22 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
22,110 |
55,000 |
0.10% |
|
|
| 23 |
Squarepoint Ops LLC |
20,000 |
50,000 |
0.09% |
|
|
| 24 |
Creative Planning |
17,000 |
43,000 |
0.07% |
|
|
| 25 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
15,000 |
38,000 |
0.07% |
|
|
| 26 |
IFP ADVISORS, INC |
12,040 |
30,000 |
0.05% |
|
|
| 27 |
HOCHMAN COLE INVESTMENT ADVISORS, INC. |
10,887 |
27,000 |
0.05% |
|
|
| 28 |
BlackRock Institutional Trust Company, N.A. |
5,728 |
14,000 |
0.02% |
|
|
| 29 |
BlackRock Investment Management, LLC |
4,596 |
12,000 |
0.02% |
|
|
| 30 |
BLACKROCK ADVISORS LLC |
4,030 |
10,000 |
0.02% |
|
|
| 31 |
ADVISOR GROUP, INC. |
2,000 |
5,000 |
0.01% |
|
|
| 32 |
FIRST MANHATTAN CO. LLC. |
1,750 |
4,000 |
0.01% |
|
|
| 33 |
UBS Group AG |
738 |
2,000 |
0.00% |
|
|
| 34 |
TCI Wealth Advisors, Inc. |
500 |
1,000 |
0.00% |
|
|
| 35 |
D.A. DAVIDSON & CO. |
720 |
1,000 |
0.00% |
|
|
| 36 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
184 |
0 |
0.00% |
|
|
| 37 |
BANK OF MONTREAL /CAN/ |
13 |
0 |
0.00% |
|
|
