| 1 |
FMR LLC |
4,307,485 |
14,516,000 |
23.35% |
|
|
| 2 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
2,596,489 |
8,750,000 |
14.07% |
|
|
| 3 |
Polaris Venture Management Co. V, L.L.C. |
2,473,186 |
8,335,000 |
13.41% |
|
|
| 4 |
Redmile Group, LLC |
2,371,001 |
7,990,000 |
12.85% |
|
|
| 5 |
WELLINGTON MANAGEMENT GROUP LLP |
1,306,569 |
4,403,000 |
7.08% |
|
|
| 6 |
Broadfin Capital, LLC |
1,113,986 |
3,754,000 |
6.04% |
|
|
| 7 |
ORBIMED ADVISORS LLC |
692,900 |
2,335,000 |
3.76% |
|
|
| 8 |
FRANKLIN RESOURCES INC |
500,000 |
1,685,000 |
2.71% |
|
|
| 9 |
VANGUARD GROUP INC |
415,243 |
1,399,000 |
2.25% |
|
|
| 10 |
PRINCIPAL FINANCIAL GROUP INC |
350,800 |
1,182,000 |
1.90% |
|
|
| 11 |
Lombard Odier Asset Management (USA) Corp |
350,306 |
1,181,000 |
1.90% |
|
|
| 12 |
Board of Trustees of The Leland Stanford Junior University |
291,067 |
981,000 |
1.58% |
|
|
| 13 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
224,537 |
757,000 |
1.22% |
|
|
| 14 |
Allianz Asset Management GmbH |
209,307 |
705,000 |
1.13% |
|
|
| 15 |
Alyeska Investment Group, L.P. |
168,881 |
569,000 |
0.92% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
108,093 |
364,000 |
0.59% |
|
|
| 17 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
100,000 |
337,000 |
0.54% |
|
|
| 18 |
MILLENNIUM MANAGEMENT LLC |
95,230 |
321,000 |
0.52% |
|
|
| 19 |
RENAISSANCE TECHNOLOGIES LLC |
88,500 |
298,000 |
0.48% |
|
|
| 20 |
Telemetry Investments, L.L.C. |
69,993 |
236,000 |
0.38% |
|
|
| 21 |
BlackRock Fund Advisors |
64,611 |
218,000 |
0.35% |
|
|
| 22 |
Bank of New York Mellon Corp |
63,428 |
213,000 |
0.34% |
|
|
| 23 |
Spark Investment Management LLC |
62,600 |
210,000 |
0.34% |
|
|
| 24 |
OXFORD ASSET MANAGEMENT LLP |
51,745 |
173,000 |
0.28% |
|
|
| 25 |
A.R.T. Advisors, LLC |
49,795 |
167,000 |
0.27% |
|
|
| 26 |
BlackRock Institutional Trust Company, N.A. |
41,816 |
141,000 |
0.23% |
|
|
| 27 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
37,253 |
126,000 |
0.20% |
|
|
| 28 |
TFS CAPITAL LLC |
32,495 |
110,000 |
0.18% |
|
|
| 29 |
GOLDMAN SACHS GROUP INC |
26,691 |
90,000 |
0.14% |
|
|
| 30 |
NORTHERN TRUST CORP |
25,531 |
86,000 |
0.14% |
|
|
| 31 |
TWO SIGMA INVESTMENTS, LP |
19,946 |
67,000 |
0.11% |
|
|
| 32 |
HOCHMAN COLE INVESTMENT ADVISORS, INC. |
16,341 |
55,000 |
0.09% |
|
|
| 33 |
Virtu KCG Holdings LLC |
15,057 |
51,000 |
0.08% |
|
|
| 34 |
CITADEL ADVISORS LLC |
14,464 |
49,000 |
0.08% |
|
|
| 35 |
NOMURA HOLDINGS INC |
13,000 |
44,000 |
0.07% |
|
|
| 36 |
BANK OF AMERICA CORP /DE/ |
12,880 |
43,000 |
0.07% |
|
|
| 37 |
Tufton Capital Management |
11,858 |
40,000 |
0.06% |
|
|
| 38 |
Walleye Trading LLC |
10,300 |
35,000 |
0.06% |
|
|
| 39 |
Creative Planning |
7,000 |
24,000 |
0.04% |
|
|
| 40 |
DEUTSCHE BANK AG\ |
6,470 |
21,000 |
0.03% |
|
|
| 41 |
BLACKROCK ADVISORS LLC |
5,699 |
19,000 |
0.03% |
|
|
| 42 |
IFP ADVISORS, INC |
5,200 |
18,000 |
0.03% |
|
|
| 43 |
MORGAN STANLEY |
5,000 |
17,000 |
0.03% |
|
|
| 44 |
BlackRock Investment Management, LLC |
4,327 |
15,000 |
0.02% |
|
|
| 45 |
UBS Group AG |
4,230 |
14,000 |
0.02% |
|
|
| 46 |
BlackRock Japan Co. Ltd |
3,948 |
13,000 |
0.02% |
|
|
| 47 |
ACADIAN ASSET MANAGEMENT LLC |
1,038 |
3,000 |
0.00% |
|
|
| 48 |
WELLS FARGO & COMPANY/MN |
1,000 |
3,000 |
0.00% |
|
|
| 49 |
FIRST MANHATTAN CO. LLC. |
1,000 |
3,000 |
0.00% |
|
|
| 50 |
D.A. DAVIDSON & CO. |
720 |
2,000 |
0.00% |
|
|
