| 1 |
FMR LLC |
3,053,573 |
19,268,000 |
30.92% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
2,473,186 |
15,606,000 |
25.04% |
|
|
| 3 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
1,197,675 |
7,797,000 |
12.51% |
|
|
| 4 |
WELLINGTON MANAGEMENT GROUP LLP |
1,194,010 |
7,533,000 |
12.09% |
|
|
| 5 |
ORBIMED ADVISORS LLC |
692,900 |
4,372,000 |
7.02% |
|
|
| 6 |
Board of Trustees of The Leland Stanford Junior University |
292,567 |
1,846,000 |
2.96% |
|
|
| 7 |
FARALLON CAPITAL MANAGEMENT LLC |
248,102 |
1,566,000 |
2.51% |
|
|
| 8 |
PRINCIPAL FINANCIAL GROUP INC |
204,000 |
1,287,000 |
2.07% |
|
|
| 9 |
VANGUARD GROUP INC |
148,606 |
938,000 |
1.51% |
|
|
| 10 |
DAFNA Capital Management LLC |
75,930 |
479,000 |
0.77% |
|
|
| 11 |
GOLDMAN SACHS GROUP INC |
67,877 |
428,000 |
0.69% |
|
|
| 12 |
Alyeska Investment Group, L.P. |
51,077 |
322,000 |
0.52% |
|
|
| 13 |
Bank of New York Mellon Corp |
38,443 |
242,000 |
0.39% |
|
|
| 14 |
DEUTSCHE BANK AG\ |
24,701 |
154,000 |
0.25% |
|
|
| 15 |
BlackRock Fund Advisors |
23,831 |
150,000 |
0.24% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
23,664 |
149,000 |
0.24% |
|
|
| 17 |
DG CAPITAL MANAGEMENT INC |
12,935 |
82,000 |
0.13% |
|
|
| 18 |
JANE STREET GROUP, LLC |
12,200 |
77,000 |
0.12% |
|
|
| 19 |
BlackRock Investment Management, LLC |
2,073 |
13,000 |
0.02% |
|
|
| 20 |
Tower Research Capital LLC (TRC) |
646 |
4,000 |
0.01% |
|
|
| 21 |
Ground Swell Capital, LLC |
100 |
1,000 |
0.00% |
|
|
