| 1 |
FMR LLC |
4,304,186 |
22,941,000 |
23.46% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
2,473,186 |
13,182,000 |
13.48% |
|
|
| 3 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
2,402,224 |
12,804,000 |
13.09% |
|
|
| 4 |
Redmile Group, LLC |
2,074,836 |
11,059,000 |
11.31% |
|
|
| 5 |
WELLINGTON MANAGEMENT GROUP LLP |
1,462,522 |
7,796,000 |
7.97% |
|
|
| 6 |
Broadfin Capital, LLC |
1,113,986 |
5,938,000 |
6.07% |
|
|
| 7 |
ORBIMED ADVISORS LLC |
692,900 |
3,693,000 |
3.78% |
|
|
| 8 |
HIGHLAND CAPITAL MANAGEMENT LP |
657,097 |
3,502,000 |
3.58% |
|
|
| 9 |
FRANKLIN RESOURCES INC |
500,000 |
2,665,000 |
2.72% |
|
|
| 10 |
VANGUARD GROUP INC |
368,979 |
1,967,000 |
2.01% |
|
|
| 11 |
PRINCIPAL FINANCIAL GROUP INC |
350,800 |
1,870,000 |
1.91% |
|
|
| 12 |
Lombard Odier Asset Management (USA) Corp |
317,088 |
1,690,000 |
1.73% |
|
|
| 13 |
Board of Trustees of The Leland Stanford Junior University |
291,067 |
1,551,000 |
1.59% |
|
|
| 14 |
Allianz Asset Management GmbH |
192,596 |
1,027,000 |
1.05% |
|
|
| 15 |
Alyeska Investment Group, L.P. |
179,386 |
956,000 |
0.98% |
|
|
| 16 |
TFS CAPITAL LLC |
121,151 |
646,000 |
0.66% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
107,965 |
575,000 |
0.59% |
|
|
| 18 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
104,000 |
554,000 |
0.57% |
|
|
| 19 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
94,437 |
503,000 |
0.51% |
|
|
| 20 |
RENAISSANCE TECHNOLOGIES LLC |
92,600 |
494,000 |
0.51% |
|
|
| 21 |
Ghost Tree Capital, LLC |
89,231 |
476,000 |
0.49% |
|
|
| 22 |
Tufton Capital Management |
77,083 |
411,000 |
0.42% |
|
|
| 23 |
Bank of New York Mellon Corp |
63,428 |
338,000 |
0.35% |
|
|
| 24 |
BlackRock Fund Advisors |
62,538 |
333,000 |
0.34% |
|
|
| 25 |
Sterling Capital Management LLC |
29,823 |
159,000 |
0.16% |
|
|
| 26 |
NORTHERN TRUST CORP |
25,531 |
136,000 |
0.14% |
|
|
| 27 |
GOLDMAN SACHS GROUP INC |
14,797 |
79,000 |
0.08% |
|
|
| 28 |
DEUTSCHE BANK AG\ |
13,800 |
73,000 |
0.07% |
|
|
| 29 |
TWO SIGMA INVESTMENTS, LP |
12,300 |
66,000 |
0.07% |
|
|
| 30 |
MILLENNIUM MANAGEMENT LLC |
10,313 |
55,000 |
0.06% |
|
|
| 31 |
Geduld E E |
10,000 |
53,000 |
0.05% |
|
|
| 32 |
MORGAN STANLEY |
9,626 |
52,000 |
0.05% |
|
|
| 33 |
BlackRock Institutional Trust Company, N.A. |
5,728 |
31,000 |
0.03% |
|
|
| 34 |
Walleye Trading LLC |
5,300 |
28,000 |
0.03% |
|
|
| 35 |
Creative Planning |
5,000 |
27,000 |
0.03% |
|
|
| 36 |
BlackRock Investment Management, LLC |
4,327 |
23,000 |
0.02% |
|
|
| 37 |
BLACKROCK ADVISORS LLC |
4,030 |
21,000 |
0.02% |
|
|
| 38 |
UBS Group AG |
3,795 |
20,000 |
0.02% |
|
|
| 39 |
WELLS FARGO & COMPANY/MN |
1,000 |
5,000 |
0.01% |
|
|
| 40 |
D.A. DAVIDSON & CO. |
720 |
3,000 |
0.00% |
|
|
| 41 |
Tower Research Capital LLC (TRC) |
160 |
1,000 |
0.00% |
|
|
| 42 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
184 |
1,000 |
0.00% |
|
|
| 43 |
ROYAL BANK OF CANADA |
103 |
1,000 |
0.00% |
|
|
| 44 |
BANK OF MONTREAL /CAN/ |
31 |
0 |
0.00% |
|
|
