| 1 |
FRANKLIN RESOURCES INC |
5,325,000 |
16,614,000 |
27.54% |
|
|
| 2 |
FMR LLC |
4,307,485 |
13,439,000 |
22.28% |
|
|
| 3 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
2,827,889 |
8,823,000 |
14.63% |
|
|
| 4 |
Polaris Venture Management Co. V, L.L.C. |
2,473,186 |
7,716,000 |
12.79% |
|
|
| 5 |
Redmile Group, LLC |
1,425,158 |
4,446,000 |
7.37% |
|
|
| 6 |
VANGUARD GROUP INC |
687,693 |
2,145,000 |
3.56% |
|
|
| 7 |
EcoR1 Capital, LLC |
590,527 |
1,842,000 |
3.05% |
|
|
| 8 |
Board of Trustees of The Leland Stanford Junior University |
291,067 |
908,000 |
1.51% |
|
|
| 9 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
250,000 |
780,000 |
1.29% |
|
|
| 10 |
Lombard Odier Asset Management (USA) Corp |
246,126 |
768,000 |
1.27% |
|
|
| 11 |
RENAISSANCE TECHNOLOGIES LLC |
188,000 |
587,000 |
0.97% |
|
|
| 12 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
124,472 |
388,000 |
0.64% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
108,093 |
337,000 |
0.56% |
|
|
| 14 |
Telemetry Investments, L.L.C. |
106,550 |
332,000 |
0.55% |
|
|
| 15 |
BlackRock Fund Advisors |
65,539 |
204,000 |
0.34% |
|
|
| 16 |
Bank of New York Mellon Corp |
61,130 |
191,000 |
0.32% |
|
|
| 17 |
NORTHERN TRUST CORP |
38,625 |
121,000 |
0.20% |
|
|
| 18 |
GOLDMAN SACHS GROUP INC |
35,417 |
111,000 |
0.18% |
|
|
| 19 |
PANAGORA ASSET MANAGEMENT INC |
29,510 |
92,000 |
0.15% |
|
|
| 20 |
WELLS FARGO & COMPANY/MN |
26,667 |
83,000 |
0.14% |
|
|
| 21 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
22,000 |
69,000 |
0.11% |
|
|
| 22 |
EMERALD ACQUISITION LTD. |
21,550 |
67,000 |
0.11% |
|
|
| 23 |
Creative Planning |
17,000 |
53,000 |
0.09% |
|
|
| 24 |
Virtu KCG Holdings LLC |
13,348 |
42,000 |
0.07% |
|
|
| 25 |
MILLENNIUM MANAGEMENT LLC |
12,136 |
38,000 |
0.06% |
|
|
| 26 |
IFP ADVISORS, INC |
6,200 |
19,000 |
0.03% |
|
|
| 27 |
BlackRock Institutional Trust Company, N.A. |
5,728 |
18,000 |
0.03% |
|
|
| 28 |
JPMORGAN CHASE & CO |
4,941 |
15,000 |
0.02% |
|
|
| 29 |
BlackRock Investment Management, LLC |
4,596 |
14,000 |
0.02% |
|
|
| 30 |
BLACKROCK ADVISORS LLC |
4,030 |
13,000 |
0.02% |
|
|
| 31 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
4,074 |
13,000 |
0.02% |
|
|
| 32 |
FIRST MANHATTAN CO. LLC. |
3,250 |
10,000 |
0.02% |
|
|
| 33 |
UBS Group AG |
2,275 |
7,000 |
0.01% |
|
|
| 34 |
ADVISOR GROUP, INC. |
2,000 |
6,000 |
0.01% |
|
|
| 35 |
Tower Research Capital LLC (TRC) |
500 |
2,000 |
0.00% |
|
|
| 36 |
D.A. DAVIDSON & CO. |
720 |
2,000 |
0.00% |
|
|
| 37 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
184 |
1,000 |
0.00% |
|
|
| 38 |
MORGAN STANLEY |
169 |
1,000 |
0.00% |
|
|
| 39 |
BANK OF MONTREAL /CAN/ |
14 |
0 |
0.00% |
|
|
