| 1 |
FMR LLC |
4,051,858 |
26,216,000 |
22.49% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
2,473,186 |
16,002,000 |
13.73% |
|
|
| 3 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
2,407,412 |
15,576,000 |
13.36% |
|
|
| 4 |
Redmile Group, LLC |
2,007,446 |
12,988,000 |
11.14% |
|
|
| 5 |
WELLINGTON MANAGEMENT GROUP LLP |
1,499,648 |
9,703,000 |
8.32% |
|
|
| 6 |
Broadfin Capital, LLC |
1,300,000 |
8,411,000 |
7.21% |
|
|
| 7 |
HIGHLAND CAPITAL MANAGEMENT LP |
922,430 |
5,968,000 |
5.12% |
|
|
| 8 |
ORBIMED ADVISORS LLC |
692,900 |
4,483,000 |
3.85% |
|
|
| 9 |
FRANKLIN RESOURCES INC |
500,000 |
3,235,000 |
2.77% |
|
|
| 10 |
PRINCIPAL FINANCIAL GROUP INC |
350,000 |
2,265,000 |
1.94% |
|
|
| 11 |
VANGUARD GROUP INC |
337,238 |
2,182,000 |
1.87% |
|
|
| 12 |
Lombard Odier Asset Management (USA) Corp |
305,481 |
1,976,000 |
1.70% |
|
|
| 13 |
Board of Trustees of The Leland Stanford Junior University |
291,067 |
1,883,000 |
1.62% |
|
|
| 14 |
Alyeska Investment Group, L.P. |
213,167 |
1,379,000 |
1.18% |
|
|
| 15 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
100,000 |
647,000 |
0.55% |
|
|
| 16 |
TFS CAPITAL LLC |
81,797 |
529,000 |
0.45% |
|
|
| 17 |
RENAISSANCE TECHNOLOGIES LLC |
80,720 |
522,000 |
0.45% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
77,947 |
504,000 |
0.43% |
|
|
| 19 |
BlackRock Fund Advisors |
64,194 |
415,000 |
0.36% |
|
|
| 20 |
Bank of New York Mellon Corp |
41,766 |
270,000 |
0.23% |
|
|
| 21 |
Sterling Capital Management LLC |
40,720 |
263,000 |
0.23% |
|
|
| 22 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
37,000 |
239,000 |
0.21% |
|
|
| 23 |
Geduld E E |
37,000 |
239,000 |
0.21% |
|
|
| 24 |
NORTHERN TRUST CORP |
29,464 |
191,000 |
0.16% |
|
|
| 25 |
DEUTSCHE BANK AG\ |
25,842 |
166,000 |
0.14% |
|
|
| 26 |
Numeric Investors LLC |
18,742 |
121,000 |
0.10% |
|
|
| 27 |
GOLDMAN SACHS GROUP INC |
12,250 |
79,000 |
0.07% |
|
|
| 28 |
MORGAN STANLEY |
8,057 |
52,000 |
0.04% |
|
|
| 29 |
BlackRock Investment Management, LLC |
4,085 |
26,000 |
0.02% |
|
|
| 30 |
WELLS FARGO & COMPANY/MN |
2,000 |
13,000 |
0.01% |
|
|
| 31 |
BlackRock Institutional Trust Company, N.A. |
1,742 |
11,000 |
0.01% |
|
|
| 32 |
BLACKROCK ADVISORS LLC |
1,168 |
8,000 |
0.01% |
|
|
| 33 |
Walleye Trading LLC |
700 |
5,000 |
0.00% |
|
|
| 34 |
D.A. DAVIDSON & CO. |
720 |
4,000 |
0.00% |
|
|
| 35 |
ROYAL BANK OF CANADA |
403 |
3,000 |
0.00% |
|
|
| 36 |
ACADIAN ASSET MANAGEMENT LLC |
306 |
2,000 |
0.00% |
|
|
| 37 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
184 |
1,000 |
0.00% |
|
|
| 38 |
CITIGROUP INC |
84 |
1,000 |
0.00% |
|
|
| 39 |
BANK OF MONTREAL /CAN/ |
23 |
0 |
0.00% |
|
|
