| 1 |
FMR LLC |
3,084,373 |
15,514,000 |
30.02% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
2,473,186 |
12,440,000 |
24.07% |
|
|
| 3 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
1,554,175 |
7,818,000 |
15.13% |
|
|
| 4 |
WELLINGTON MANAGEMENT GROUP LLP |
1,420,928 |
7,147,000 |
13.83% |
|
|
| 5 |
ORBIMED ADVISORS LLC |
692,900 |
3,485,000 |
6.74% |
|
|
| 6 |
Board of Trustees of The Leland Stanford Junior University |
291,067 |
1,464,000 |
2.83% |
|
|
| 7 |
PRINCIPAL FINANCIAL GROUP INC |
207,700 |
1,045,000 |
2.02% |
|
|
| 8 |
VANGUARD GROUP INC |
171,938 |
865,000 |
1.67% |
|
|
| 9 |
Alyeska Investment Group, L.P. |
76,494 |
385,000 |
0.74% |
|
|
| 10 |
GOLDMAN SACHS GROUP INC |
73,436 |
369,000 |
0.71% |
|
|
| 11 |
DAFNA Capital Management LLC |
59,110 |
297,000 |
0.57% |
|
|
| 12 |
Bank of New York Mellon Corp |
38,443 |
193,000 |
0.37% |
|
|
| 13 |
HIGHLAND CAPITAL MANAGEMENT LP |
33,275 |
167,000 |
0.32% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
31,384 |
157,000 |
0.30% |
|
|
| 15 |
DEUTSCHE BANK AG\ |
30,796 |
154,000 |
0.30% |
|
|
| 16 |
BlackRock Fund Advisors |
23,926 |
120,000 |
0.23% |
|
|
| 17 |
MORGAN STANLEY |
4,035 |
20,000 |
0.04% |
|
|
| 18 |
UBS Group AG |
2,264 |
11,000 |
0.02% |
|
|
| 19 |
BlackRock Investment Management, LLC |
2,248 |
11,000 |
0.02% |
|
|
| 20 |
WELLS FARGO & COMPANY/MN |
2,000 |
10,000 |
0.02% |
|
|
| 21 |
MUFG Americas Holdings Corp |
770 |
4,000 |
0.01% |
|
|
| 22 |
FIRST MANHATTAN CO. LLC. |
700 |
3,000 |
0.01% |
|
|
| 23 |
Tower Research Capital LLC (TRC) |
200 |
1,000 |
0.00% |
|
|
