| 1 |
FMR LLC |
4,307,485 |
7,323,000 |
31.51% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
2,473,186 |
4,204,000 |
18.09% |
|
|
| 3 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
2,257,920 |
3,838,000 |
16.51% |
|
|
| 4 |
Redmile Group, LLC |
1,502,180 |
2,554,000 |
10.99% |
|
|
| 5 |
VANGUARD GROUP INC |
657,573 |
1,118,000 |
4.81% |
|
|
| 6 |
FRANKLIN RESOURCES INC |
500,000 |
850,000 |
3.66% |
|
|
| 7 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
394,537 |
671,000 |
2.89% |
|
|
| 8 |
Board of Trustees of The Leland Stanford Junior University |
291,067 |
495,000 |
2.13% |
|
|
| 9 |
Lombard Odier Asset Management (USA) Corp |
256,426 |
436,000 |
1.88% |
|
|
| 10 |
RENAISSANCE TECHNOLOGIES LLC |
180,700 |
307,000 |
1.32% |
|
|
| 11 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
178,647 |
304,000 |
1.31% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
108,029 |
183,000 |
0.79% |
|
|
| 13 |
Telemetry Investments, L.L.C. |
85,000 |
144,000 |
0.62% |
|
|
| 14 |
EMERALD ACQUISITION LTD. |
80,604 |
137,000 |
0.59% |
|
|
| 15 |
BlackRock Fund Advisors |
75,572 |
128,000 |
0.55% |
|
|
| 16 |
Bank of New York Mellon Corp |
68,444 |
117,000 |
0.50% |
|
|
| 17 |
GOLDMAN SACHS GROUP INC |
35,966 |
61,000 |
0.26% |
|
|
| 18 |
BANK OF AMERICA CORP /DE/ |
28,320 |
48,000 |
0.21% |
|
|
| 19 |
NORTHERN TRUST CORP |
25,531 |
43,000 |
0.19% |
|
|
| 20 |
Nationwide Fund Advisors |
22,578 |
38,000 |
0.16% |
|
|
| 21 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
22,000 |
37,000 |
0.16% |
|
|
| 22 |
TFS CAPITAL LLC |
20,925 |
36,000 |
0.15% |
|
|
| 23 |
Allianz Asset Management GmbH |
18,252 |
31,000 |
0.13% |
|
|
| 24 |
DEUTSCHE BANK AG\ |
17,792 |
30,000 |
0.13% |
|
|
| 25 |
Creative Planning |
17,000 |
29,000 |
0.12% |
|
|
| 26 |
HOCHMAN COLE INVESTMENT ADVISORS, INC. |
11,005 |
19,000 |
0.08% |
|
|
| 27 |
FIRST MANHATTAN CO. LLC. |
7,750 |
13,000 |
0.06% |
|
|
| 28 |
BlackRock Institutional Trust Company, N.A. |
5,728 |
10,000 |
0.04% |
|
|
| 29 |
IFP ADVISORS, INC |
5,200 |
9,000 |
0.04% |
|
|
| 30 |
BLACKROCK ADVISORS LLC |
4,030 |
7,000 |
0.03% |
|
|
| 31 |
BlackRock Investment Management, LLC |
4,327 |
7,000 |
0.03% |
|
|
| 32 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
4,140 |
7,000 |
0.03% |
|
|
| 33 |
WELLS FARGO & COMPANY/MN |
1,000 |
2,000 |
0.01% |
|
|
| 34 |
MORGAN STANLEY |
1,030 |
2,000 |
0.01% |
|
|
| 35 |
Walleye Trading LLC |
1,100 |
2,000 |
0.01% |
|
|
| 36 |
D.A. DAVIDSON & CO. |
720 |
1,000 |
0.00% |
|
|
| 37 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
184 |
0 |
0.00% |
|
|
| 38 |
BANK OF MONTREAL /CAN/ |
285 |
0 |
0.00% |
|
|
