| 1 |
FMR LLC |
4,307,485 |
7,753,000 |
28.16% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
2,473,186 |
4,452,000 |
16.17% |
|
|
| 3 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
2,257,920 |
4,064,000 |
14.76% |
|
|
| 4 |
Redmile Group, LLC |
1,486,980 |
2,677,000 |
9.72% |
|
|
| 5 |
ORBIMED ADVISORS LLC |
692,900 |
1,247,000 |
4.53% |
|
|
| 6 |
VANGUARD GROUP INC |
635,475 |
1,144,000 |
4.15% |
|
|
| 7 |
FRANKLIN RESOURCES INC |
500,000 |
900,000 |
3.27% |
|
|
| 8 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
474,537 |
854,000 |
3.10% |
|
|
| 9 |
PRINCIPAL FINANCIAL GROUP INC |
293,900 |
529,000 |
1.92% |
|
|
| 10 |
Board of Trustees of The Leland Stanford Junior University |
285,953 |
515,000 |
1.87% |
|
|
| 11 |
Lombard Odier Asset Management (USA) Corp |
249,374 |
449,000 |
1.63% |
|
|
| 12 |
RENAISSANCE TECHNOLOGIES LLC |
222,700 |
401,000 |
1.46% |
|
|
| 13 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
204,447 |
368,000 |
1.34% |
|
|
| 14 |
Allianz Asset Management GmbH |
197,329 |
355,000 |
1.29% |
|
|
| 15 |
GOLDMAN SACHS GROUP INC |
173,924 |
313,000 |
1.14% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
108,029 |
194,000 |
0.70% |
|
|
| 17 |
Telemetry Investments, L.L.C. |
96,500 |
174,000 |
0.63% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
69,394 |
125,000 |
0.45% |
|
|
| 19 |
Bank of New York Mellon Corp |
63,503 |
114,000 |
0.41% |
|
|
| 20 |
Spark Investment Management LLC |
63,700 |
114,000 |
0.41% |
|
|
| 21 |
TWO SIGMA INVESTMENTS, LP |
61,141 |
110,000 |
0.40% |
|
|
| 22 |
BlackRock Fund Advisors |
59,871 |
108,000 |
0.39% |
|
|
| 23 |
DEUTSCHE BANK AG\ |
43,455 |
78,000 |
0.28% |
|
|
| 24 |
RUSSELL FRANK CO/ |
39,300 |
71,000 |
0.26% |
|
|
| 25 |
MILLENNIUM MANAGEMENT LLC |
36,697 |
66,000 |
0.24% |
|
|
| 26 |
BANK OF AMERICA CORP /DE/ |
28,228 |
51,000 |
0.19% |
|
|
| 27 |
NORTHERN TRUST CORP |
25,531 |
46,000 |
0.17% |
|
|
| 28 |
Nationwide Fund Advisors |
22,578 |
41,000 |
0.15% |
|
|
| 29 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
22,000 |
40,000 |
0.15% |
|
|
| 30 |
MORGAN STANLEY |
20,002 |
36,000 |
0.13% |
|
|
| 31 |
Creative Planning |
17,000 |
31,000 |
0.11% |
|
|
| 32 |
HOCHMAN COLE INVESTMENT ADVISORS, INC. |
16,341 |
29,000 |
0.11% |
|
|
| 33 |
WEDBUSH SECURITIES INC |
11,500 |
21,000 |
0.08% |
|
|
| 34 |
BLACKROCK ADVISORS LLC |
8,811 |
16,000 |
0.06% |
|
|
| 35 |
BlackRock Japan Co. Ltd |
5,909 |
11,000 |
0.04% |
|
|
| 36 |
IFP ADVISORS, INC |
5,200 |
9,000 |
0.03% |
|
|
| 37 |
BlackRock Investment Management, LLC |
4,327 |
8,000 |
0.03% |
|
|
| 38 |
FIRST MANHATTAN CO. LLC. |
4,000 |
7,000 |
0.03% |
|
|
| 39 |
Tower Research Capital LLC (TRC) |
3,263 |
6,000 |
0.02% |
|
|
| 40 |
UBS Group AG |
2,127 |
4,000 |
0.01% |
|
|
| 41 |
WELLS FARGO & COMPANY/MN |
1,000 |
2,000 |
0.01% |
|
|
| 42 |
Walleye Trading LLC |
1,300 |
2,000 |
0.01% |
|
|
| 43 |
D.A. DAVIDSON & CO. |
720 |
1,000 |
0.00% |
|
|
| 44 |
BANK OF MONTREAL /CAN/ |
7 |
0 |
0.00% |
|
|
| 45 |
CITIGROUP INC |
13 |
0 |
0.00% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
184 |
0 |
0.00% |
|
|
