| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Security, LLC | 19,816,162 | 180,327,000 | 21.77% | ||
| 2 | IRIDIAN ASSET MANAGEMENT LLC/CT | 6,935,095 | 63,109,000 | 7.62% | ||
| 3 | BB BIOTECH AG | 6,430,532 | 58,518,000 | 7.07% | ||
| 4 | VANGUARD GROUP INC | 6,260,802 | 56,974,000 | 6.88% | ||
| 5 | SECTORAL ASSET MANAGEMENT INC | 4,558,982 | 41,487,000 | 5.01% | ||
| 6 | QVT Financial LP | 4,055,590 | 36,906,000 | 4.46% | ||
| 7 | BlackRock Fund Advisors | 3,757,433 | 34,193,000 | 4.13% | ||
| 8 | First Eagle Investment Management, LLC | 3,640,480 | 33,128,000 | 4.00% | ||
| 9 | STATE STREET CORP | 3,270,710 | 29,763,000 | 3.59% | ||
| 10 | FMR LLC | 3,207,340 | 29,187,000 | 3.52% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,904,204 | 26,428,000 | 3.19% | ||
| 12 | BAKER BROS. ADVISORS LP | 2,776,143 | 25,263,000 | 3.05% | ||
| 13 | JPMORGAN CHASE & CO | 1,917,792 | 17,452,000 | 2.11% | ||
| 14 | Lombard Odier Asset Management (USA) Corp | 1,499,214 | 13,643,000 | 1.65% | ||
| 15 | JHL Capital Group LLC | 1,425,000 | 12,968,000 | 1.57% | ||
| 16 | VOYA INVESTMENT MANAGEMENT LLC | 1,393,082 | 12,677,000 | 1.53% | ||
| 17 | NORTHERN TRUST CORP | 1,165,040 | 10,601,000 | 1.28% | ||
| 18 | NORGES BANK | 1,031,007 | 9,382,000 | 1.13% | ||
| 19 | OppenheimerFunds, Inc. | 1,000,000 | 9,100,000 | 1.10% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 829,300 | 7,547,000 | 0.91% | Call | |
| 21 | Fisher Asset Management, LLC | 762,780 | 6,941,000 | 0.84% | ||
| 22 | CREDIT SUISSE AG/ | 722,600 | 6,576,000 | 0.79% | Put | |
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 585,204 | 5,324,000 | 0.64% | ||
| 24 | Bank of New York Mellon Corp | 543,772 | 4,949,000 | 0.60% | ||
| 25 | CREDIT SUISSE AG/ | 521,301 | 4,743,000 | 0.57% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 512,546 | 4,664,000 | 0.56% | ||
| 27 | DEUTSCHE BANK AG\ | 472,731 | 4,298,000 | 0.52% | ||
| 28 | PANAGORA ASSET MANAGEMENT INC | 471,484 | 4,291,000 | 0.52% | ||
| 29 | OXFORD ASSET MANAGEMENT LLP | 391,073 | 3,601,000 | 0.43% | ||
| 30 | MORGAN STANLEY | 359,748 | 3,274,000 | 0.40% | ||
| 31 | HARVEY CAPITAL MANAGEMENT INC | 348,550 | 3,171,000 | 0.38% | ||
| 32 | GUGGENHEIM CAPITAL LLC | 324,094 | 2,949,000 | 0.36% | ||
| 33 | PICTET ASSET MANAGEMENT LTD | 313,600 | 2,854,000 | 0.34% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 304,289 | 2,769,000 | 0.33% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 286,427 | 2,607,000 | 0.31% | ||
| 36 | BlackRock Investment Management, LLC | 283,706 | 2,582,000 | 0.31% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 265,700 | 2,418,000 | 0.29% | Put | |
| 38 | STATE OF WISCONSIN INVESTMENT BOARD | 260,000 | 2,366,000 | 0.29% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 235,581 | 2,144,000 | 0.26% | ||
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 232,000 | 2,111,000 | 0.25% | ||
| 41 | Numeric Investors LLC | 202,200 | 1,840,000 | 0.22% | ||
| 42 | Callan Capital, LLC | 199,230 | 1,813,000 | 0.22% | ||
| 43 | ALLIANCEBERNSTEIN L.P. | 197,214 | 1,795,000 | 0.22% | ||
| 44 | CITADEL ADVISORS LLC | 192,038 | 1,747,000 | 0.21% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 191,132 | 1,739,000 | 0.21% | ||
| 46 | State of New Jersey Common Pension Fund D | 180,000 | 1,638,000 | 0.20% | ||
| 47 | ROYAL BANK OF CANADA | 176,800 | 1,609,000 | 0.19% | Call | |
| 48 | GOLDMAN SACHS GROUP INC | 168,904 | 1,537,000 | 0.19% | ||
| 49 | Janney Montgomery Scott LLC | 158,225 | 1,439,848 | 0.17% | ||
| 50 | TEACHERS ADVISORS, LLC | 144,799 | 1,318,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
