| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Security, LLC | 19,305,403 | 233,209,000 | 17.76% | ||
| 2 | IRIDIAN ASSET MANAGEMENT LLC/CT | 9,290,024 | 112,223,000 | 8.55% | ||
| 3 | VANGUARD GROUP INC | 8,199,259 | 99,047,000 | 7.54% | ||
| 4 | FMR LLC | 7,806,475 | 94,302,000 | 7.18% | ||
| 5 | First Eagle Investment Management, LLC | 7,395,500 | 89,338,000 | 6.80% | ||
| 6 | BB BIOTECH AG | 7,379,832 | 89,148,000 | 6.79% | ||
| 7 | BlackRock Fund Advisors | 4,518,198 | 54,580,000 | 4.16% | ||
| 8 | STATE STREET CORP | 3,261,211 | 39,398,000 | 3.00% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 3,005,011 | 36,301,000 | 2.76% | ||
| 10 | JPMORGAN CHASE & CO | 2,980,634 | 36,006,000 | 2.74% | ||
| 11 | SNYDER CAPITAL MANAGEMENT L P | 2,232,114 | 26,964,000 | 2.05% | ||
| 12 | FRANKLIN RESOURCES INC | 2,229,069 | 26,927,000 | 2.05% | ||
| 13 | Sterling Global Strategies LLC | 287,760 | 22,266,000 | 1.70% | ||
| 14 | Invesco Ltd. | 1,810,904 | 21,876,000 | 1.67% | ||
| 15 | BAKER BROS. ADVISORS LP | 1,731,057 | 20,911,000 | 1.59% | ||
| 16 | Bank of New York Mellon Corp | 1,722,504 | 20,808,000 | 1.58% | ||
| 17 | VOYA INVESTMENT MANAGEMENT LLC | 1,705,777 | 20,606,000 | 1.57% | ||
| 18 | NORTHERN TRUST CORP | 1,309,023 | 15,813,000 | 1.20% | ||
| 19 | OppenheimerFunds, Inc. | 1,000,000 | 12,080,000 | 0.92% | ||
| 20 | NORGES BANK | 1,014,852 | 11,709,000 | 0.89% | ||
| 21 | MSD Partners, L.P. | 965,000 | 11,657,000 | 0.89% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 844,687 | 10,203,000 | 0.78% | ||
| 23 | PANAGORA ASSET MANAGEMENT INC | 797,081 | 9,629,000 | 0.73% | ||
| 24 | Fisher Asset Management, LLC | 725,011 | 8,758,000 | 0.67% | ||
| 25 | TEACHERS ADVISORS, LLC | 721,044 | 8,710,000 | 0.66% | ||
| 26 | SENZAR ASSET MANAGEMENT, LLC | 550,544 | 6,650,572 | 0.51% | ||
| 27 | KENNEDY CAPITAL MANAGEMENT LLC | 538,543 | 6,506,000 | 0.50% | ||
| 28 | CREDIT SUISSE AG/ | 512,921 | 6,197,000 | 0.47% | ||
| 29 | DEUTSCHE BANK AG\ | 485,122 | 5,858,000 | 0.45% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 480,600 | 5,806,000 | 0.44% | Call | |
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 432,651 | 5,227,000 | 0.40% | ||
| 32 | NEW YORK STATE COMMON RETIREMENT FUND | 422,340 | 5,102,000 | 0.39% | ||
| 33 | BlackRock Investment Management, LLC | 411,838 | 4,975,000 | 0.38% | ||
| 34 | MORGAN STANLEY | 363,703 | 4,393,000 | 0.33% | ||
| 35 | FRED ALGER MANAGEMENT, LLC | 359,009 | 4,337,000 | 0.33% | ||
| 36 | Lombard Odier Asset Management (USA) Corp | 350,904 | 4,239,000 | 0.32% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 325,965 | 3,938,000 | 0.30% | ||
| 38 | BELLEVUE GROUP AG | 318,000 | 3,841,000 | 0.29% | ||
| 39 | MACQUARIE GROUP LTD | 304,800 | 3,682,000 | 0.28% | ||
| 40 | J. Goldman & Co LP | 282,900 | 3,417,000 | 0.26% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 282,100 | 3,408,000 | 0.26% | Put | |
| 42 | BROWN ADVISORY INC | 264,360 | 3,193,000 | 0.24% | ||
| 43 | Candriam S.C.A. | 262,000 | 3,165,000 | 0.24% | ||
| 44 | SEI INVESTMENTS CO | 258,885 | 3,127,000 | 0.24% | ||
| 45 | Rhenman & Partners Asset Management AB | 250,000 | 3,020,000 | 0.23% | ||
| 46 | BLACKROCK ADVISORS LLC | 247,706 | 2,992,000 | 0.23% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 230,738 | 2,787,000 | 0.21% | ||
| 48 | GUGGENHEIM CAPITAL LLC | 230,263 | 2,782,000 | 0.21% | ||
| 49 | Allianz Asset Management GmbH | 227,920 | 2,735,000 | 0.21% | ||
| 50 | MILLENNIUM MANAGEMENT LLC | 220,098 | 2,659,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
