| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Security, LLC | 19,829,337 | 187,784,000 | 18.91% | ||
| 2 | IRIDIAN ASSET MANAGEMENT LLC/CT | 8,745,524 | 82,820,000 | 8.34% | ||
| 3 | VANGUARD GROUP INC | 7,536,888 | 71,374,000 | 7.19% | ||
| 4 | BB BIOTECH AG | 7,379,832 | 69,887,000 | 7.04% | ||
| 5 | First Eagle Investment Management, LLC | 6,663,700 | 63,105,000 | 6.35% | ||
| 6 | FMR LLC | 5,945,680 | 56,306,000 | 5.67% | ||
| 7 | BlackRock Fund Advisors | 4,302,729 | 40,747,000 | 4.10% | ||
| 8 | STATE STREET CORP | 3,472,472 | 32,884,000 | 3.31% | ||
| 9 | JPMORGAN CHASE & CO | 3,099,576 | 29,353,000 | 2.96% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,850,270 | 26,992,000 | 2.72% | ||
| 11 | Invesco Ltd. | 2,723,463 | 25,791,000 | 2.60% | ||
| 12 | FRANKLIN RESOURCES INC | 2,219,933 | 21,022,000 | 2.12% | ||
| 13 | BAKER BROS. ADVISORS LP | 1,931,057 | 18,287,000 | 1.84% | ||
| 14 | SNYDER CAPITAL MANAGEMENT L P | 1,680,169 | 15,911,000 | 1.60% | ||
| 15 | VOYA INVESTMENT MANAGEMENT LLC | 1,459,396 | 13,820,000 | 1.39% | ||
| 16 | NORTHERN TRUST CORP | 1,273,797 | 12,062,000 | 1.21% | ||
| 17 | Lombard Odier Asset Management (USA) Corp | 1,073,154 | 10,163,000 | 1.02% | ||
| 18 | NORGES BANK | 1,019,337 | 9,654,000 | 0.97% | ||
| 19 | OppenheimerFunds, Inc. | 1,000,000 | 9,470,000 | 0.95% | ||
| 20 | MSD Partners, L.P. | 920,000 | 8,712,000 | 0.88% | ||
| 21 | Fisher Asset Management, LLC | 707,780 | 8,472,000 | 0.85% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 744,320 | 7,048,000 | 0.71% | ||
| 23 | PANAGORA ASSET MANAGEMENT INC | 742,510 | 7,032,000 | 0.71% | ||
| 24 | TEACHERS ADVISORS, LLC | 706,111 | 6,687,000 | 0.67% | ||
| 25 | QVT Financial LP | 694,436 | 6,576,000 | 0.66% | ||
| 26 | DEUTSCHE BANK AG\ | 684,663 | 6,482,000 | 0.65% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 672,300 | 6,367,000 | 0.64% | Call | |
| 28 | CREDIT SUISSE AG/ | 529,047 | 5,009,000 | 0.50% | ||
| 29 | Bank of New York Mellon Corp | 496,634 | 4,704,000 | 0.47% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 440,935 | 4,176,000 | 0.42% | ||
| 31 | Rhenman & Partners Asset Management AB | 431,000 | 4,082,000 | 0.41% | ||
| 32 | OXFORD ASSET MANAGEMENT LLP | 430,476 | 4,077,000 | 0.41% | ||
| 33 | FRED ALGER MANAGEMENT, LLC | 414,706 | 3,927,000 | 0.40% | ||
| 34 | Parallax Volatility Advisers, L.P. | 383,100 | 3,628,000 | 0.37% | Call | |
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 380,290 | 3,601,000 | 0.36% | ||
| 36 | RENAISSANCE TECHNOLOGIES LLC | 375,000 | 3,551,000 | 0.36% | ||
| 37 | BlackRock Investment Management, LLC | 370,079 | 3,505,000 | 0.35% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 362,450 | 3,432,000 | 0.35% | ||
| 39 | GOLDMAN SACHS GROUP INC | 332,496 | 3,148,000 | 0.32% | ||
| 40 | BELLEVUE GROUP AG | 318,000 | 3,011,000 | 0.30% | ||
| 41 | MACQUARIE GROUP LTD | 304,800 | 2,886,000 | 0.29% | ||
| 42 | MORGAN STANLEY | 296,757 | 2,809,000 | 0.28% | ||
| 43 | MILLENNIUM MANAGEMENT LLC | 292,428 | 2,769,000 | 0.28% | ||
| 44 | GUGGENHEIM CAPITAL LLC | 267,806 | 2,536,000 | 0.26% | ||
| 45 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 250,400 | 2,371,000 | 0.24% | Call | |
| 46 | Candriam S.C.A. | 232,000 | 2,185,000 | 0.22% | ||
| 47 | BLACKROCK ADVISORS LLC | 227,105 | 2,151,000 | 0.22% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 225,378 | 2,134,000 | 0.21% | ||
| 49 | SEI INVESTMENTS CO | 218,765 | 2,072,000 | 0.21% | ||
| 50 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 218,700 | 2,071,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
