| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Security, LLC | 19,829,337 | 447,746,000 | 19.92% | ||
| 2 | IRIDIAN ASSET MANAGEMENT LLC/CT | 9,662,663 | 218,183,000 | 9.71% | ||
| 3 | VANGUARD GROUP INC | 6,862,761 | 154,961,000 | 6.89% | ||
| 4 | BB BIOTECH AG | 6,077,168 | 137,222,000 | 6.11% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 5,500,691 | 124,206,000 | 5.53% | ||
| 6 | FMR LLC | 4,318,194 | 97,505,000 | 4.34% | ||
| 7 | BlackRock Fund Advisors | 4,199,129 | 94,816,000 | 4.22% | ||
| 8 | First Eagle Investment Management, LLC | 4,162,000 | 93,978,000 | 4.18% | ||
| 9 | SECTORAL ASSET MANAGEMENT INC | 3,477,051 | 78,512,000 | 3.49% | ||
| 10 | STATE STREET CORP | 2,985,625 | 67,414,000 | 3.00% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,765,185 | 62,438,000 | 2.78% | ||
| 12 | FRANKLIN RESOURCES INC | 2,069,425 | 46,728,000 | 2.08% | ||
| 13 | BAKER BROS. ADVISORS LP | 1,931,057 | 43,603,000 | 1.94% | ||
| 14 | Lombard Odier Asset Management (USA) Corp | 1,697,504 | 38,329,000 | 1.71% | ||
| 15 | JPMORGAN CHASE & CO | 1,649,750 | 37,251,000 | 1.66% | ||
| 16 | NORTHERN TRUST CORP | 1,176,272 | 26,560,000 | 1.18% | ||
| 17 | Invesco Ltd. | 1,102,276 | 24,889,000 | 1.11% | ||
| 18 | OppenheimerFunds, Inc. | 1,000,000 | 22,580,000 | 1.00% | ||
| 19 | VOYA INVESTMENT MANAGEMENT LLC | 959,251 | 21,660,000 | 0.96% | ||
| 20 | NORGES BANK | 794,752 | 17,945,000 | 0.80% | ||
| 21 | Fisher Asset Management, LLC | 740,955 | 16,731,000 | 0.74% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 680,137 | 15,356,000 | 0.68% | ||
| 23 | QVT Financial LP | 672,883 | 15,194,000 | 0.68% | ||
| 24 | CREDIT SUISSE AG/ | 648,848 | 14,650,000 | 0.65% | ||
| 25 | Bank of New York Mellon Corp | 648,452 | 14,643,000 | 0.65% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 608,300 | 13,735,000 | 0.61% | Call | |
| 27 | DEUTSCHE BANK AG\ | 591,203 | 13,347,000 | 0.59% | ||
| 28 | PANAGORA ASSET MANAGEMENT INC | 586,200 | 13,236,000 | 0.59% | ||
| 29 | PEAK6 Group LLC | 465,000 | 10,500,000 | 0.47% | Call | |
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 462,335 | 10,440,000 | 0.46% | ||
| 31 | NEW YORK STATE COMMON RETIREMENT FUND | 412,835 | 9,322,000 | 0.41% | ||
| 32 | MORGAN STANLEY | 392,657 | 8,866,000 | 0.39% | ||
| 33 | GUGGENHEIM CAPITAL LLC | 383,039 | 8,649,000 | 0.38% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 368,375 | 8,318,000 | 0.37% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 363,387 | 8,205,000 | 0.37% | ||
| 36 | BlackRock Investment Management, LLC | 359,561 | 8,119,000 | 0.36% | ||
| 37 | CREDIT SUISSE AG/ | 300,000 | 6,774,000 | 0.30% | Put | |
| 38 | FRED ALGER MANAGEMENT, LLC | 288,526 | 6,515,000 | 0.29% | ||
| 39 | PICTET ASSET MANAGEMENT LTD | 239,500 | 5,590,000 | 0.25% | ||
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 232,000 | 5,239,000 | 0.23% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 223,600 | 5,049,000 | 0.22% | Put | |
| 42 | Lombard Odier Asset Management (Switzerland) SA | 218,000 | 4,922,000 | 0.22% | ||
| 43 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 200,084 | 4,517,000 | 0.20% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 197,214 | 4,453,000 | 0.20% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 193,714 | 4,374,000 | 0.19% | ||
| 46 | State of New Jersey Common Pension Fund D | 180,000 | 4,064,000 | 0.18% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 177,967 | 4,018,000 | 0.18% | ||
| 48 | BLACKROCK ADVISORS LLC | 173,567 | 3,919,000 | 0.17% | ||
| 49 | Rhenman & Partners Asset Management AB | 172,000 | 3,884,000 | 0.17% | ||
| 50 | D. E. Shaw & Co., Inc. | 164,480 | 3,714,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
