| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Security, LLC | 19,791,286 | 251,547,000 | 22.74% | ||
| 2 | VANGUARD GROUP INC | 6,152,087 | 78,132,000 | 7.06% | ||
| 3 | BAKER BROS. ADVISORS LP | 5,698,139 | 72,366,000 | 6.54% | ||
| 4 | BB BIOTECH AG | 5,641,564 | 71,676,000 | 6.48% | ||
| 5 | SECTORAL ASSET MANAGEMENT INC | 5,355,488 | 68,041,000 | 6.15% | ||
| 6 | FMR LLC | 5,275,340 | 66,997,000 | 6.06% | ||
| 7 | QVT Financial LP | 4,218,800 | 53,600,000 | 4.84% | ||
| 8 | BlackRock Fund Advisors | 3,958,701 | 50,295,000 | 4.55% | ||
| 9 | FRANKLIN RESOURCES INC | 3,318,700 | 42,147,000 | 3.81% | ||
| 10 | IRIDIAN ASSET MANAGEMENT LLC/CT | 3,232,154 | 41,065,000 | 3.71% | ||
| 11 | STATE STREET CORP | 2,969,709 | 37,720,000 | 3.41% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 2,823,050 | 35,867,000 | 3.24% | ||
| 13 | JPMORGAN CHASE & CO | 1,664,033 | 21,143,000 | 1.91% | ||
| 14 | First Eagle Investment Management, LLC | 1,433,780 | 18,209,000 | 1.65% | ||
| 15 | NORTHERN TRUST CORP | 1,274,963 | 16,198,000 | 1.46% | ||
| 16 | NORGES BANK | 1,031,007 | 13,094,000 | 1.18% | ||
| 17 | VOYA INVESTMENT MANAGEMENT LLC | 591,182 | 7,509,000 | 0.68% | ||
| 18 | DEUTSCHE BANK AG\ | 552,527 | 7,018,000 | 0.63% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 549,479 | 6,978,000 | 0.63% | ||
| 20 | CREDIT SUISSE AG/ | 518,993 | 6,595,000 | 0.60% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 483,500 | 6,143,000 | 0.56% | Put | |
| 22 | Bank of New York Mellon Corp | 475,779 | 6,044,000 | 0.55% | ||
| 23 | OXFORD ASSET MANAGEMENT LLP | 457,047 | 5,804,000 | 0.52% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 400,000 | 5,082,000 | 0.46% | Call | |
| 25 | HARVEY CAPITAL MANAGEMENT INC | 392,050 | 4,980,000 | 0.45% | ||
| 26 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 391,890 | 4,978,000 | 0.45% | ||
| 27 | MORGAN STANLEY | 357,182 | 4,538,000 | 0.41% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 356,131 | 4,523,000 | 0.41% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 320,369 | 4,070,000 | 0.37% | ||
| 30 | GUGGENHEIM CAPITAL LLC | 319,915 | 4,063,000 | 0.37% | ||
| 31 | PICTET ASSET MANAGEMENT LTD | 304,300 | 3,865,000 | 0.35% | ||
| 32 | PANAGORA ASSET MANAGEMENT INC | 298,391 | 3,790,000 | 0.34% | ||
| 33 | CREDIT SUISSE AG/ | 292,200 | 3,712,000 | 0.34% | Put | |
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 271,047 | 3,443,000 | 0.31% | ||
| 35 | BlackRock Investment Management, LLC | 266,258 | 3,383,000 | 0.31% | ||
| 36 | ProShare Advisors LLC | 192,565 | 2,446,000 | 0.22% | ||
| 37 | GOLDMAN SACHS GROUP INC | 189,899 | 2,412,000 | 0.22% | ||
| 38 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 187,584 | 2,384,000 | 0.22% | ||
| 39 | ALLIANCEBERNSTEIN L.P. | 187,217 | 2,378,000 | 0.21% | ||
| 40 | State of New Jersey Common Pension Fund A | 180,000 | 2,286,000 | 0.21% | ||
| 41 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 179,859 | 2,286,000 | 0.21% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 175,248 | 2,226,000 | 0.20% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 165,721 | 2,106,000 | 0.19% | ||
| 44 | Callan Capital, LLC | 165,000 | 2,096,000 | 0.19% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 236,700 | 1,962,000 | 0.18% | ||
| 46 | TEACHERS ADVISORS, LLC | 138,808 | 1,763,000 | 0.16% | ||
| 47 | RENAISSANCE TECHNOLOGIES LLC | 135,400 | 1,720,000 | 0.16% | ||
| 48 | AXA S.A. | 122,706 | 1,558,000 | 0.14% | ||
| 49 | Swiss National Bank | 115,000 | 1,461,000 | 0.13% | ||
| 50 | Janney Montgomery Scott LLC | 114,241 | 1,451,434 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
