| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Security, LLC | 19,305,403 | 166,606,000 | 18.13% | ||
| 2 | IRIDIAN ASSET MANAGEMENT LLC/CT | 8,191,274 | 70,691,000 | 7.69% | ||
| 3 | VANGUARD GROUP INC | 7,608,228 | 65,658,000 | 7.14% | ||
| 4 | BB BIOTECH AG | 7,379,832 | 63,688,000 | 6.93% | ||
| 5 | First Eagle Investment Management, LLC | 7,101,000 | 61,282,000 | 6.67% | ||
| 6 | FMR LLC | 6,691,247 | 57,745,000 | 6.28% | ||
| 7 | BlackRock Fund Advisors | 4,352,218 | 37,560,000 | 4.09% | ||
| 8 | STATE STREET CORP | 3,578,450 | 30,880,000 | 3.36% | ||
| 9 | JPMORGAN CHASE & CO | 3,082,218 | 26,600,000 | 2.89% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,845,357 | 24,555,000 | 2.67% | ||
| 11 | Bank of New York Mellon Corp | 2,279,701 | 19,674,000 | 2.14% | ||
| 12 | SNYDER CAPITAL MANAGEMENT L P | 2,267,787 | 19,571,000 | 2.13% | ||
| 13 | FRANKLIN RESOURCES INC | 2,216,929 | 19,132,000 | 2.08% | ||
| 14 | VOYA INVESTMENT MANAGEMENT LLC | 1,875,872 | 16,189,000 | 1.76% | ||
| 15 | BAKER BROS. ADVISORS LP | 1,838,057 | 15,862,000 | 1.73% | ||
| 16 | Invesco Ltd. | 1,793,534 | 15,479,000 | 1.68% | ||
| 17 | NORTHERN TRUST CORP | 1,311,180 | 11,315,000 | 1.23% | ||
| 18 | OppenheimerFunds, Inc. | 1,000,000 | 8,630,000 | 0.94% | ||
| 19 | PANAGORA ASSET MANAGEMENT INC | 984,723 | 8,498,000 | 0.92% | ||
| 20 | MSD Partners, L.P. | 965,000 | 8,328,000 | 0.91% | ||
| 21 | Lombard Odier Asset Management (USA) Corp | 948,803 | 8,188,000 | 0.89% | ||
| 22 | NORGES BANK | 837,637 | 7,229,000 | 0.79% | ||
| 23 | DEUTSCHE BANK AG\ | 836,355 | 7,216,000 | 0.79% | ||
| 24 | SENZAR ASSET MANAGEMENT, LLC | 785,744 | 6,780,971 | 0.74% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 776,138 | 6,698,000 | 0.73% | ||
| 26 | Fisher Asset Management, LLC | 725,011 | 6,583,000 | 0.72% | ||
| 27 | TEACHERS ADVISORS, LLC | 721,934 | 6,230,000 | 0.68% | ||
| 28 | CREDIT SUISSE AG/ | 505,652 | 4,364,000 | 0.47% | ||
| 29 | QVT Financial LP | 500,449 | 4,319,000 | 0.47% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 468,300 | 4,041,000 | 0.44% | Call | |
| 31 | FRED ALGER MANAGEMENT, LLC | 432,289 | 3,731,000 | 0.41% | ||
| 32 | OXFORD ASSET MANAGEMENT LLP | 416,512 | 3,594,000 | 0.39% | ||
| 33 | BlackRock Investment Management, LLC | 406,054 | 3,504,000 | 0.38% | ||
| 34 | NEW YORK STATE COMMON RETIREMENT FUND | 382,670 | 3,302,000 | 0.36% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 373,642 | 3,225,000 | 0.35% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 370,285 | 3,196,000 | 0.35% | ||
| 37 | MORGAN STANLEY | 355,607 | 3,069,000 | 0.33% | ||
| 38 | GOLDMAN SACHS GROUP INC | 350,596 | 3,026,000 | 0.33% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 342,036 | 2,952,000 | 0.32% | ||
| 40 | BELLEVUE GROUP AG | 318,000 | 2,744,000 | 0.30% | ||
| 41 | MACQUARIE GROUP LTD | 304,800 | 2,630,000 | 0.29% | ||
| 42 | Janney Montgomery Scott LLC | 138,155 | 2,394,000 | 0.26% | ||
| 43 | BROWN ADVISORY INC | 266,860 | 2,303,000 | 0.25% | ||
| 44 | GUGGENHEIM CAPITAL LLC | 253,563 | 2,188,000 | 0.24% | ||
| 45 | Parallax Volatility Advisers, L.P. | 250,000 | 2,158,000 | 0.23% | Call | |
| 46 | Rhenman & Partners Asset Management AB | 250,000 | 2,158,000 | 0.23% | ||
| 47 | BLACKROCK ADVISORS LLC | 229,716 | 1,982,000 | 0.22% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 228,638 | 1,973,000 | 0.21% | ||
| 49 | SEI INVESTMENTS CO | 223,280 | 1,927,000 | 0.21% | ||
| 50 | UBS Group AG | 221,524 | 1,911,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
