| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Security, LLC | 19,829,337 | 266,308,000 | 19.46% | ||
| 2 | IRIDIAN ASSET MANAGEMENT LLC/CT | 8,184,003 | 109,911,000 | 8.03% | ||
| 3 | VANGUARD GROUP INC | 7,162,903 | 96,198,000 | 7.03% | ||
| 4 | BB BIOTECH AG | 6,929,832 | 93,068,000 | 6.80% | ||
| 5 | FMR LLC | 4,939,208 | 66,334,000 | 4.85% | ||
| 6 | BlackRock Fund Advisors | 4,437,512 | 59,596,000 | 4.36% | ||
| 7 | First Eagle Investment Management, LLC | 4,058,500 | 54,506,000 | 3.98% | ||
| 8 | STATE STREET CORP | 3,103,381 | 41,679,000 | 3.05% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 3,067,386 | 41,195,000 | 3.01% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,717,579 | 36,497,000 | 2.67% | ||
| 11 | SECTORAL ASSET MANAGEMENT INC | 2,671,051 | 35,872,000 | 2.62% | ||
| 12 | Invesco Ltd. | 2,461,836 | 33,062,000 | 2.42% | ||
| 13 | JPMORGAN CHASE & CO | 2,016,926 | 27,088,000 | 1.98% | ||
| 14 | ALPS ADVISORS INC | 199,192 | 26,751,000 | 1.96% | ||
| 15 | BAKER BROS. ADVISORS LP | 1,931,057 | 25,934,000 | 1.90% | ||
| 16 | FRANKLIN RESOURCES INC | 1,806,737 | 24,265,000 | 1.77% | ||
| 17 | NORTHERN TRUST CORP | 1,224,455 | 16,446,000 | 1.20% | ||
| 18 | NORGES BANK | 1,105,337 | 14,845,000 | 1.09% | ||
| 19 | Lombard Odier Asset Management (USA) Corp | 1,061,547 | 14,257,000 | 1.04% | ||
| 20 | OppenheimerFunds, Inc. | 1,000,000 | 13,430,000 | 0.98% | ||
| 21 | VOYA INVESTMENT MANAGEMENT LLC | 951,846 | 12,783,000 | 0.93% | ||
| 22 | Fisher Asset Management, LLC | 707,780 | 9,505,000 | 0.69% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 699,444 | 9,393,000 | 0.69% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 635,800 | 8,539,000 | 0.62% | Call | |
| 25 | PANAGORA ASSET MANAGEMENT INC | 598,213 | 8,034,000 | 0.59% | ||
| 26 | CREDIT SUISSE AG/ | 560,934 | 7,534,000 | 0.55% | ||
| 27 | DEUTSCHE BANK AG\ | 542,375 | 7,283,000 | 0.53% | ||
| 28 | FRED ALGER MANAGEMENT, LLC | 522,527 | 7,018,000 | 0.51% | ||
| 29 | Bank of New York Mellon Corp | 506,171 | 6,799,000 | 0.50% | ||
| 30 | QVT Financial LP | 486,276 | 6,531,000 | 0.48% | ||
| 31 | PRUDENTIAL FINANCIAL INC | 477,066 | 6,407,000 | 0.47% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 441,722 | 5,932,000 | 0.43% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 427,195 | 5,738,000 | 0.42% | ||
| 34 | GUGGENHEIM CAPITAL LLC | 376,382 | 5,055,000 | 0.37% | ||
| 35 | GOLDMAN SACHS GROUP INC | 355,373 | 4,773,000 | 0.35% | ||
| 36 | NEW YORK STATE COMMON RETIREMENT FUND | 353,845 | 4,752,000 | 0.35% | ||
| 37 | BlackRock Investment Management, LLC | 353,733 | 4,751,000 | 0.35% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 338,293 | 4,543,000 | 0.33% | ||
| 39 | AMERICAN CENTURY COMPANIES INC | 337,211 | 4,529,000 | 0.33% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 337,100 | 4,527,000 | 0.33% | Put | |
| 41 | MORGAN STANLEY | 315,653 | 4,239,000 | 0.31% | ||
| 42 | CAPITAL FUND MANAGEMENT S.A. | 313,231 | 4,207,000 | 0.31% | ||
| 43 | CREDIT SUISSE AG/ | 300,000 | 4,029,000 | 0.29% | Put | |
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 298,636 | 4,011,000 | 0.29% | ||
| 45 | CITADEL ADVISORS LLC | 279,493 | 3,753,000 | 0.27% | ||
| 46 | PEAK6 Group LLC | 277,100 | 3,721,000 | 0.27% | Call | |
| 47 | PICTET ASSET MANAGEMENT LTD | 276,800 | 3,717,000 | 0.27% | ||
| 48 | BLACKROCK ADVISORS LLC | 265,306 | 3,563,000 | 0.26% | ||
| 49 | Convergence Investment Partners, LLC | 251,748 | 3,381,000 | 0.25% | ||
| 50 | BELLEVUE ASSET MANAGEMENT AG | 246,000 | 3,304,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
