| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Security, LLC | 19,816,162 | 282,975,000 | 20.80% | ||
| 2 | IRIDIAN ASSET MANAGEMENT LLC/CT | 8,208,323 | 117,215,000 | 8.62% | ||
| 3 | VANGUARD GROUP INC | 6,596,056 | 94,192,000 | 6.92% | ||
| 4 | BB BIOTECH AG | 6,423,370 | 91,726,000 | 6.74% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 4,750,128 | 67,832,000 | 4.99% | ||
| 6 | BlackRock Fund Advisors | 4,203,845 | 60,031,000 | 4.41% | ||
| 7 | First Eagle Investment Management, LLC | 3,834,050 | 54,750,000 | 4.03% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 3,727,551 | 53,229,000 | 3.91% | ||
| 9 | FMR LLC | 3,627,337 | 51,798,000 | 3.81% | ||
| 10 | STATE STREET CORP | 3,076,968 | 43,937,000 | 3.23% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,907,935 | 41,525,000 | 3.05% | ||
| 12 | BAKER BROS. ADVISORS LP | 2,248,152 | 32,104,000 | 2.36% | ||
| 13 | FRANKLIN RESOURCES INC | 1,972,246 | 28,164,000 | 2.07% | ||
| 14 | Lombard Odier Asset Management (USA) Corp | 1,749,691 | 24,986,000 | 1.84% | ||
| 15 | JPMORGAN CHASE & CO | 1,671,867 | 23,874,000 | 1.76% | ||
| 16 | VOYA INVESTMENT MANAGEMENT LLC | 1,384,182 | 19,766,000 | 1.45% | ||
| 17 | NORTHERN TRUST CORP | 1,138,171 | 16,254,000 | 1.19% | ||
| 18 | OppenheimerFunds, Inc. | 1,000,000 | 14,280,000 | 1.05% | ||
| 19 | QVT Financial LP | 851,305 | 12,157,000 | 0.89% | ||
| 20 | DEUTSCHE BANK AG\ | 779,826 | 11,133,000 | 0.82% | ||
| 21 | Fisher Asset Management, LLC | 762,780 | 10,892,000 | 0.80% | ||
| 22 | NORGES BANK | 740,152 | 10,569,000 | 0.78% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 657,669 | 9,391,000 | 0.69% | ||
| 24 | PANAGORA ASSET MANAGEMENT INC | 623,762 | 8,907,000 | 0.65% | ||
| 25 | Bank of New York Mellon Corp | 622,210 | 8,884,000 | 0.65% | ||
| 26 | CREDIT SUISSE AG/ | 570,430 | 8,146,000 | 0.60% | ||
| 27 | PICTET ASSET MANAGEMENT LTD | 472,930 | 7,033,000 | 0.52% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 470,495 | 6,719,000 | 0.49% | ||
| 29 | GUGGENHEIM CAPITAL LLC | 383,367 | 5,474,000 | 0.40% | ||
| 30 | RENAISSANCE TECHNOLOGIES LLC | 380,800 | 5,438,000 | 0.40% | ||
| 31 | JHL Capital Group LLC | 375,000 | 5,355,000 | 0.39% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 333,892 | 4,768,000 | 0.35% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 311,355 | 4,447,000 | 0.33% | ||
| 34 | Candriam S.C.A. | 310,000 | 4,428,000 | 0.33% | ||
| 35 | OXFORD ASSET MANAGEMENT LLP | 303,939 | 4,340,000 | 0.32% | ||
| 36 | CREDIT SUISSE AG/ | 300,000 | 4,284,000 | 0.31% | Put | |
| 37 | MORGAN STANLEY | 292,545 | 4,178,000 | 0.31% | ||
| 38 | BlackRock Investment Management, LLC | 285,925 | 4,083,000 | 0.30% | ||
| 39 | CITADEL ADVISORS LLC | 276,935 | 3,955,000 | 0.29% | ||
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 276,130 | 3,943,000 | 0.29% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 274,793 | 3,924,000 | 0.29% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 244,500 | 3,491,000 | 0.26% | Call | |
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 232,000 | 3,359,000 | 0.25% | ||
| 44 | GOLDMAN SACHS GROUP INC | 231,475 | 3,305,000 | 0.24% | ||
| 45 | Informed Momentum Co LLC | 224,384 | 3,204,000 | 0.24% | ||
| 46 | PEAK6 Group LLC | 210,000 | 2,999,000 | 0.22% | Call | |
| 47 | ALLIANCEBERNSTEIN L.P. | 197,214 | 2,816,000 | 0.21% | ||
| 48 | SABBY MANAGEMENT, LLC | 191,621 | 2,736,000 | 0.20% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 189,348 | 2,704,000 | 0.20% | ||
| 50 | State of New Jersey Common Pension Fund D | 180,000 | 2,570,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
