| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Security, LLC | 19,816,162 | 191,226,000 | 21.32% | ||
| 2 | IRIDIAN ASSET MANAGEMENT LLC/CT | 7,274,065 | 70,195,000 | 7.83% | ||
| 3 | BB BIOTECH AG | 6,825,532 | 65,866,000 | 7.34% | ||
| 4 | VANGUARD GROUP INC | 6,284,638 | 60,647,000 | 6.76% | ||
| 5 | BlackRock Fund Advisors | 4,102,773 | 39,592,000 | 4.41% | ||
| 6 | First Eagle Investment Management, LLC | 3,990,480 | 38,508,000 | 4.29% | ||
| 7 | STATE STREET CORP | 3,725,138 | 35,950,000 | 4.01% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 3,724,351 | 35,940,000 | 4.01% | ||
| 9 | FMR LLC | 3,322,440 | 32,062,000 | 3.57% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,912,435 | 28,105,000 | 3.13% | ||
| 11 | BAKER BROS. ADVISORS LP | 2,776,143 | 26,790,000 | 2.99% | ||
| 12 | Lombard Odier Asset Management (USA) Corp | 2,700,000 | 26,055,000 | 2.91% | ||
| 13 | QVT Financial LP | 2,010,186 | 19,398,000 | 2.16% | ||
| 14 | JPMORGAN CHASE & CO | 1,795,732 | 17,329,000 | 1.93% | ||
| 15 | VOYA INVESTMENT MANAGEMENT LLC | 1,604,282 | 15,481,000 | 1.73% | ||
| 16 | JHL Capital Group LLC | 1,475,000 | 14,234,000 | 1.59% | ||
| 17 | NORTHERN TRUST CORP | 1,120,058 | 10,809,000 | 1.21% | ||
| 18 | OppenheimerFunds, Inc. | 1,000,000 | 9,650,000 | 1.08% | ||
| 19 | Fisher Asset Management, LLC | 762,780 | 7,361,000 | 0.82% | ||
| 20 | BALYASNY ASSET MANAGEMENT L.P. | 758,645 | 7,321,000 | 0.82% | ||
| 21 | DEUTSCHE BANK AG\ | 755,257 | 7,286,000 | 0.81% | ||
| 22 | NORGES BANK | 740,152 | 7,142,000 | 0.80% | ||
| 23 | CREDIT SUISSE AG/ | 722,600 | 6,973,000 | 0.78% | Put | |
| 24 | MILLENNIUM MANAGEMENT LLC | 717,258 | 6,922,000 | 0.77% | ||
| 25 | CREDIT SUISSE AG/ | 592,873 | 5,722,000 | 0.64% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 584,391 | 5,638,000 | 0.63% | ||
| 27 | PICTET ASSET MANAGEMENT LTD | 583,475 | 5,631,000 | 0.63% | ||
| 28 | Bank of New York Mellon Corp | 546,438 | 5,273,000 | 0.59% | ||
| 29 | STATE OF WISCONSIN INVESTMENT BOARD | 500,000 | 4,825,000 | 0.54% | ||
| 30 | PANAGORA ASSET MANAGEMENT INC | 499,410 | 4,819,000 | 0.54% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 488,183 | 4,711,000 | 0.53% | ||
| 32 | GUGGENHEIM CAPITAL LLC | 419,567 | 4,049,000 | 0.45% | ||
| 33 | MAZAMA CAPITAL MANAGEMENT INC | 358,087 | 3,456,000 | 0.39% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 351,400 | 3,391,000 | 0.38% | Call | |
| 35 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 232,000 | 3,359,000 | 0.37% | ||
| 36 | Alden Global Capital Ltd | 332,500 | 3,209,000 | 0.36% | ||
| 37 | MORGAN STANLEY | 309,460 | 2,986,000 | 0.33% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 296,421 | 2,861,000 | 0.32% | ||
| 39 | Candriam S.C.A. | 285,000 | 2,750,000 | 0.31% | ||
| 40 | BlackRock Investment Management, LLC | 282,731 | 2,728,000 | 0.30% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 236,600 | 2,283,000 | 0.25% | Put | |
| 42 | BANK OF AMERICA CORP /DE/ | 219,882 | 2,122,000 | 0.24% | ||
| 43 | OXFORD ASSET MANAGEMENT LLP | 210,403 | 1,978,000 | 0.22% | ||
| 44 | Callan Capital, LLC | 199,230 | 1,923,000 | 0.21% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 197,214 | 1,903,000 | 0.21% | ||
| 46 | GOLDMAN SACHS GROUP INC | 192,907 | 1,861,000 | 0.21% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 191,948 | 1,852,000 | 0.21% | ||
| 48 | State of New Jersey Common Pension Fund D | 180,000 | 1,737,000 | 0.19% | ||
| 49 | EcoR1 Capital, LLC | 160,700 | 1,551,000 | 0.17% | Call | |
| 50 | Janney Montgomery Scott LLC | 155,320 | 1,498,838 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
