| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Security, LLC | 19,829,337 | 343,642,000 | 19.72% | ||
| 2 | IRIDIAN ASSET MANAGEMENT LLC/CT | 8,684,184 | 150,497,000 | 8.64% | ||
| 3 | VANGUARD GROUP INC | 7,440,205 | 128,938,000 | 7.40% | ||
| 4 | BB BIOTECH AG | 7,029,832 | 121,827,000 | 6.99% | ||
| 5 | FMR LLC | 6,320,880 | 109,541,000 | 6.29% | ||
| 6 | First Eagle Investment Management, LLC | 4,305,900 | 74,621,000 | 4.28% | ||
| 7 | BlackRock Fund Advisors | 4,198,609 | 72,762,000 | 4.17% | ||
| 8 | STATE STREET CORP | 2,996,665 | 51,931,000 | 2.98% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,878,642 | 49,887,000 | 2.86% | ||
| 10 | Invesco Ltd. | 2,391,473 | 41,444,000 | 2.38% | ||
| 11 | SECTORAL ASSET MANAGEMENT INC | 2,075,796 | 35,974,000 | 2.06% | ||
| 12 | BAKER BROS. ADVISORS LP | 1,931,057 | 33,465,000 | 1.92% | ||
| 13 | JPMORGAN CHASE & CO | 1,888,493 | 32,729,000 | 1.88% | ||
| 14 | FRANKLIN RESOURCES INC | 1,816,288 | 31,476,000 | 1.81% | ||
| 15 | Bank of New York Mellon Corp | 1,788,946 | 31,003,000 | 1.78% | ||
| 16 | NORTHERN TRUST CORP | 1,252,282 | 21,702,000 | 1.25% | ||
| 17 | NORGES BANK | 1,105,337 | 19,156,000 | 1.10% | ||
| 18 | Lombard Odier Asset Management (USA) Corp | 1,100,000 | 19,063,000 | 1.09% | ||
| 19 | OppenheimerFunds, Inc. | 1,000,000 | 17,330,000 | 0.99% | ||
| 20 | VOYA INVESTMENT MANAGEMENT LLC | 842,421 | 14,599,000 | 0.84% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 747,424 | 12,952,000 | 0.74% | ||
| 22 | Fisher Asset Management, LLC | 707,780 | 12,266,000 | 0.70% | ||
| 23 | PRUDENTIAL FINANCIAL INC | 662,166 | 11,475,000 | 0.66% | ||
| 24 | PANAGORA ASSET MANAGEMENT INC | 643,114 | 11,145,000 | 0.64% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 625,200 | 10,835,000 | 0.62% | Call | |
| 26 | DEUTSCHE BANK AG\ | 569,672 | 9,870,000 | 0.57% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 508,400 | 8,811,000 | 0.51% | Put | |
| 28 | CREDIT SUISSE AG/ | 490,986 | 8,509,000 | 0.49% | ||
| 29 | FRED ALGER MANAGEMENT, LLC | 490,084 | 8,493,000 | 0.49% | ||
| 30 | QVT Financial LP | 486,276 | 8,427,000 | 0.48% | ||
| 31 | Lombard Odier Asset Management (Switzerland) SA | 480,000 | 8,318,000 | 0.48% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 472,533 | 8,189,000 | 0.47% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 455,630 | 7,897,000 | 0.45% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 421,386 | 7,303,000 | 0.42% | ||
| 35 | Rhenman & Partners Asset Management AB | 410,000 | 7,105,000 | 0.41% | ||
| 36 | AMERICAN CENTURY COMPANIES INC | 396,771 | 6,876,000 | 0.39% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 391,566 | 6,786,000 | 0.39% | ||
| 38 | NEW YORK STATE COMMON RETIREMENT FUND | 372,785 | 6,460,000 | 0.37% | ||
| 39 | BlackRock Investment Management, LLC | 355,507 | 6,161,000 | 0.35% | ||
| 40 | GOLDMAN SACHS GROUP INC | 325,079 | 5,633,000 | 0.32% | ||
| 41 | BELLEVUE ASSET MANAGEMENT AG | 318,000 | 5,511,000 | 0.32% | ||
| 42 | UBS Group AG | 308,310 | 5,343,000 | 0.31% | ||
| 43 | PICTET ASSET MANAGEMENT LTD | 303,800 | 5,265,000 | 0.30% | ||
| 44 | CREDIT SUISSE AG/ | 300,000 | 5,199,000 | 0.30% | Put | |
| 45 | GUGGENHEIM CAPITAL LLC | 290,713 | 5,038,000 | 0.29% | ||
| 46 | PEAK6 Group LLC | 275,400 | 4,773,000 | 0.27% | Call | |
| 47 | WELLINGTON MANAGEMENT GROUP LLP | 268,195 | 4,648,000 | 0.27% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 255,600 | 4,430,000 | 0.25% | ||
| 49 | CAPITAL FUND MANAGEMENT S.A. | 253,063 | 4,386,000 | 0.25% | ||
| 50 | MORGAN STANLEY | 246,751 | 4,276,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
