| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Security, LLC | 19,305,403 | 250,198,000 | 16.53% | ||
| 2 | BlackRock Finance, Inc. | 11,062,842 | 143,374,000 | 9.47% | ||
| 3 | IRIDIAN ASSET MANAGEMENT LLC/CT | 10,400,388 | 134,789,000 | 8.91% | ||
| 4 | VANGUARD GROUP INC | 8,763,558 | 113,576,000 | 7.51% | ||
| 5 | BB BIOTECH AG | 7,749,832 | 100,438,000 | 6.64% | ||
| 6 | First Eagle Investment Management, LLC | 7,394,315 | 95,830,000 | 6.33% | ||
| 7 | FMR LLC | 6,096,781 | 79,014,000 | 5.22% | ||
| 8 | Invesco Ltd. | 4,484,611 | 58,121,000 | 3.84% | ||
| 9 | STATE STREET CORP | 3,614,672 | 46,842,000 | 3.10% | ||
| 10 | SENZAR ASSET MANAGEMENT, LLC | 3,489,864 | 45,229,000 | 2.99% | ||
| 11 | JPMORGAN CHASE & CO | 2,915,415 | 37,784,000 | 2.50% | ||
| 12 | SNYDER CAPITAL MANAGEMENT L P | 2,318,433 | 30,047,000 | 1.99% | ||
| 13 | Bank of New York Mellon Corp | 1,806,490 | 23,412,000 | 1.55% | ||
| 14 | VOYA INVESTMENT MANAGEMENT LLC | 1,551,283 | 20,105,000 | 1.33% | ||
| 15 | PICTET ASSET MANAGEMENT LTD | 1,457,426 | 18,888,000 | 1.25% | ||
| 16 | BAKER BROS. ADVISORS LP | 1,391,507 | 18,034,000 | 1.19% | ||
| 17 | NORTHERN TRUST CORP | 1,385,414 | 17,955,000 | 1.19% | ||
| 18 | Artisan Partners Limited Partnership | 1,035,837 | 13,424,000 | 0.89% | ||
| 19 | NORGES BANK | 1,014,852 | 13,153,000 | 0.87% | ||
| 20 | OppenheimerFunds, Inc. | 1,002,176 | 12,988,000 | 0.86% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 986,000 | 12,779,000 | 0.84% | Call | |
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 962,500 | 12,473,000 | 0.82% | ||
| 23 | PANAGORA ASSET MANAGEMENT INC | 880,358 | 11,409,000 | 0.75% | ||
| 24 | MSD Partners, L.P. | 765,000 | 9,914,000 | 0.66% | ||
| 25 | KENNEDY CAPITAL MANAGEMENT LLC | 696,445 | 9,026,000 | 0.60% | ||
| 26 | NEW YORK STATE COMMON RETIREMENT FUND | 678,108 | 8,788,000 | 0.58% | ||
| 27 | Fisher Asset Management, LLC | 616,511 | 7,990,000 | 0.53% | ||
| 28 | MORGAN STANLEY | 511,460 | 6,628,000 | 0.44% | ||
| 29 | AMERIPRISE FINANCIAL INC | 500,613 | 6,488,000 | 0.43% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 465,766 | 6,037,000 | 0.40% | ||
| 31 | MACQUARIE GROUP LTD | 460,000 | 5,962,000 | 0.39% | ||
| 32 | First Light Asset Management, LLC | 414,611 | 5,373,000 | 0.36% | ||
| 33 | FRED ALGER MANAGEMENT, LLC | 364,014 | 4,718,000 | 0.31% | ||
| 34 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 358,000 | 4,636,000 | 0.31% | ||
| 35 | SEI INVESTMENTS CO | 309,725 | 4,014,000 | 0.27% | ||
| 36 | WELLS FARGO & COMPANY/MN | 303,626 | 3,935,000 | 0.26% | ||
| 37 | Lombard Odier Asset Management (Switzerland) SA | 300,000 | 3,888,000 | 0.26% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 295,613 | 3,831,000 | 0.25% | ||
| 39 | BELLEVUE GROUP AG | 270,000 | 3,499,000 | 0.23% | ||
| 40 | CREDIT SUISSE AG/ | 261,374 | 3,386,000 | 0.22% | ||
| 41 | DEUTSCHE BANK AG\ | 247,882 | 3,210,000 | 0.21% | ||
| 42 | MILLENNIUM MANAGEMENT LLC | 239,687 | 3,106,000 | 0.21% | ||
| 43 | Candriam S.C.A. | 217,000 | 2,812,000 | 0.19% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 214,738 | 2,783,000 | 0.18% | ||
| 45 | GOLDMAN SACHS GROUP INC | 210,027 | 2,722,000 | 0.18% | ||
| 46 | Tekla Capital Management LLC | 200,000 | 2,592,000 | 0.17% | ||
| 47 | BROWN ADVISORY INC | 198,838 | 2,577,000 | 0.17% | ||
| 48 | TEACHERS ADVISORS, LLC | 190,502 | 2,469,000 | 0.16% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 190,300 | 2,466,000 | 0.16% | ||
| 50 | GUGGENHEIM CAPITAL LLC | 184,124 | 2,385,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
