| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 4,919,625 | 60,610,000 | 18.53% | ||
| 2 | FRANKLIN RESOURCES INC | 3,680,581 | 45,345,000 | 13.86% | ||
| 3 | Broadfin Capital, LLC | 2,808,173 | 34,597,000 | 10.58% | ||
| 4 | BAKER BROS. ADVISORS LP | 2,607,784 | 32,128,000 | 9.82% | ||
| 5 | Savitr Capital, LLC | 1,833,614 | 22,590,000 | 6.91% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 1,634,555 | 20,138,000 | 6.16% | ||
| 7 | VHCP Management, LLC | 1,095,734 | 13,499,000 | 4.13% | ||
| 8 | Tekla Capital Management LLC | 873,940 | 10,767,000 | 3.29% | ||
| 9 | DRIEHAUS CAPITAL MANAGEMENT LLC | 779,275 | 9,601,000 | 2.94% | ||
| 10 | Cormorant Asset Management, LP | 700,000 | 8,624,000 | 2.64% | ||
| 11 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 638,315 | 7,864,000 | 2.40% | ||
| 12 | VANGUARD GROUP INC | 486,924 | 5,999,000 | 1.83% | ||
| 13 | BlackRock Fund Advisors | 478,271 | 5,892,000 | 1.80% | ||
| 14 | FMR LLC | 456,320 | 5,622,000 | 1.72% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 379,946 | 4,681,000 | 1.43% | ||
| 16 | FEDERATED HERMES, INC. | 375,000 | 4,620,000 | 1.41% | ||
| 17 | EMERALD ADVISERS, LLC | 283,850 | 3,497,000 | 1.07% | ||
| 18 | THB ASSET MANAGEMENT | 280,818 | 3,459,000 | 1.06% | ||
| 19 | EMERALD MUTUAL FUND ADVISERS TRUST | 275,600 | 3,395,000 | 1.04% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 213,006 | 2,624,000 | 0.80% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 198,188 | 2,442,000 | 0.75% | ||
| 22 | STATE STREET CORP | 185,162 | 2,281,000 | 0.70% | ||
| 23 | SABBY MANAGEMENT, LLC | 135,281 | 1,667,000 | 0.51% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 109,784 | 1,352,000 | 0.41% | ||
| 25 | Bank of New York Mellon Corp | 84,270 | 1,038,000 | 0.32% | ||
| 26 | DEUTSCHE BANK AG\ | 82,476 | 1,015,000 | 0.31% | ||
| 27 | TURNER INVESTMENTS LLC | 75,000 | 924,000 | 0.28% | ||
| 28 | AQR CAPITAL MANAGEMENT LLC | 75,000 | 924,000 | 0.28% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 72,491 | 893,000 | 0.27% | ||
| 30 | Ghost Tree Capital, LLC | 70,000 | 862,000 | 0.26% | ||
| 31 | Forward Management, LLC | 70,921 | 822,000 | 0.25% | ||
| 32 | GLG Partners LP | 59,290 | 730,000 | 0.22% | ||
| 33 | BlackRock Investment Management, LLC | 54,645 | 673,000 | 0.21% | ||
| 34 | NORTHERN TRUST CORP | 47,107 | 581,000 | 0.18% | ||
| 35 | TUDOR INVESTMENT CORP ET AL | 40,800 | 503,000 | 0.15% | ||
| 36 | GOLDMAN SACHS GROUP INC | 39,986 | 493,000 | 0.15% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,500 | 437,000 | 0.13% | ||
| 38 | JANE STREET GROUP, LLC | 31,145 | 384,000 | 0.12% | ||
| 39 | TFS CAPITAL LLC | 30,057 | 370,000 | 0.11% | ||
| 40 | Spark Investment Management LLC | 29,600 | 364,000 | 0.11% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 28,500 | 352,000 | 0.11% | ||
| 42 | TEACHERS ADVISORS, LLC | 26,021 | 321,000 | 0.10% | ||
| 43 | METROPOLITAN LIFE INSURANCE CO/NY | 22,917 | 282,000 | 0.09% | ||
| 44 | SG Americas Securities, LLC | 20,448 | 252,000 | 0.08% | ||
| 45 | VOYA INVESTMENT MANAGEMENT LLC | 17,249 | 213,000 | 0.07% | ||
| 46 | Geduld E E | 16,362 | 202,000 | 0.06% | ||
| 47 | Nationwide Fund Advisors | 14,414 | 178,000 | 0.05% | ||
| 48 | RHUMBLINE ADVISERS | 13,950 | 172,000 | 0.05% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,439 | 166,000 | 0.05% | ||
| 50 | AMERICAN INTERNATIONAL GROUP, INC. | 13,232 | 163,018 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
