| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 4,408,987 | 61,329,000 | 21.21% | ||
| 2 | FRANKLIN RESOURCES INC | 3,251,353 | 45,226,000 | 15.64% | ||
| 3 | Broadfin Capital, LLC | 2,233,173 | 31,063,000 | 10.74% | ||
| 4 | BAKER BROS. ADVISORS LP | 2,167,784 | 30,153,000 | 10.43% | ||
| 5 | Savitr Capital, LLC | 1,856,761 | 25,828,000 | 8.93% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 1,762,426 | 24,515,000 | 8.48% | ||
| 7 | VHCP Management, LLC | 1,095,734 | 15,242,000 | 5.27% | ||
| 8 | DRIEHAUS CAPITAL MANAGEMENT LLC | 924,231 | 12,856,000 | 4.45% | ||
| 9 | Tekla Capital Management LLC | 696,597 | 9,690,000 | 3.35% | ||
| 10 | FMR LLC | 487,820 | 6,786,000 | 2.35% | ||
| 11 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 373,315 | 5,185,000 | 1.79% | ||
| 12 | ISZO CAPITAL MANAGEMENT LP | 347,051 | 4,827,000 | 1.67% | ||
| 13 | THB ASSET MANAGEMENT | 181,945 | 2,530,000 | 0.87% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 172,697 | 2,402,000 | 0.83% | ||
| 15 | GLG Partners LP | 126,182 | 1,755,000 | 0.61% | ||
| 16 | ASCEND CAPITAL, LLC | 125,663 | 1,749,000 | 0.60% | ||
| 17 | MORGAN STANLEY | 116,761 | 1,624,000 | 0.56% | ||
| 18 | Forward Management, LLC | 93,014 | 1,127,000 | 0.39% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 62,243 | 865,000 | 0.30% | ||
| 20 | Moab Capital Partners LLC | 55,734 | 775,000 | 0.27% | ||
| 21 | UBS AG | 52,176 | 726,000 | 0.25% | ||
| 22 | JANE STREET GROUP, LLC | 44,760 | 622,000 | 0.22% | ||
| 23 | TUDOR INVESTMENT CORP ET AL | 24,999 | 348,000 | 0.12% | ||
| 24 | Geduld E E | 25,000 | 348,000 | 0.12% | ||
| 25 | NORTHERN TRUST CORP | 21,453 | 298,000 | 0.10% | ||
| 26 | GOLDMAN SACHS GROUP INC | 16,803 | 234,000 | 0.08% | ||
| 27 | CREDIT SUISSE AG/ | 16,600 | 231,000 | 0.08% | ||
| 28 | LMR Partners LLP | 14,367 | 200,000 | 0.07% | ||
| 29 | BlueCrest Capital Management LLP | 13,800 | 192,000 | 0.07% | ||
| 30 | TFS CAPITAL LLC | 13,651 | 190,000 | 0.07% | ||
| 31 | STATE STREET CORP | 12,400 | 173,000 | 0.06% | ||
| 32 | DEUTSCHE BANK AG\ | 3,213 | 44,000 | 0.02% | ||
| 33 | TradeLink Global Equity LLC | 1,200 | 17,000 | 0.01% | ||
| 34 | Tower Research Capital LLC (TRC) | 1,123 | 16,000 | 0.01% | ||
| 35 | DIMENSIONAL FUND ADVISORS LP | 580 | 8,000 | 0.00% | ||
| 36 | COLONY GROUP LLC | 143 | 2,000 | 0.00% | ||
| 37 | AMERICAN INTERNATIONAL GROUP, INC. | 120 | 1,669 | 0.00% | ||
| 38 | WELLS FARGO & COMPANY/MN | 100 | 1,000 | 0.00% | ||
| 39 | CITIGROUP INC | 69 | 1,000 | 0.00% | ||
| 40 | Winslow, Evans & Crocker, Inc. | 1 | 14 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
